The Mechanism by which Cycloheximide and Related Glutarimide Antibiotics Inhibit Peptide Synthesis on Reticulocyte Ribosomes

Cycloheximide: Aspects of Inhibition of Protein Synthesis in Mammalian Cells

1964 • 423 citations

Initiation of protein synthesis II a convenient assay for the ribosome-dependent synthesis of N-formyl-C14-methionylpuromycin

1966 • 353 citations

Initiation of Haemoglobin Synthesis by Methionyl-tRNA

1970 • 278 citations

Cytoplasmic Methionine Transfer RNAs from Eukaryotes

1970 • 273 citations

Catalysis of peptide bond formation by 50 s ribosomal subunits from Escherichia coli

1967 • 272 citations

Role of Methionine in the Initiation of Haemoglobin Synthesis

1970 • 258 citations

CHARACTERIZATION OF A RIBOSOME-LINKED GUANOSINE TRIPHOSPHATASE IN ESCHERICHIA COLI EXTRACTS

1964 • 245 citations

Effect of cycloheximide on ribosomal aggregates engaged in protein synthesis in vitro

1964 • 232 citations

Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics

1968 • 216 citations

The mechanism of sodium fluoride and cycloheximide inhibition of hemoglobin biosynthesis in the cell-free reticulocyte system

1966 • 202 citations

Mechanism of Cycloheximide Inhibition of Protein Synthesis in a Cell-free System Prepared from Rat Liver

1969 • 201 citations

The Effect of Actidione and other Antifungal Agents on Nucleic Acid and Protein Synthesis in Saccharomyces carlsbergensis

1958 • 197 citations

Ribosome-catalysed peptidyl transfer: Effects of some inhibitors of protein synthesis

1967 • 192 citations

Inhibition of protein synthesis by cycloheximide in rabbit reticulocytes

1965 • 165 citations

The mechanism of cycloheximide inhibition of protein synthesis in rabbit reticulocytes

1969 • 159 citations

Initiator Codons in Eukaryotes

1970 • 157 citations

Purification and Partial Characterization of the Aminoacyl Transfer Ribonucleic Acid Binding Enzyme from Rabbit Reticulocytes

1969 • 141 citations

Inhibition of the synthesis of protein in intact animals by acetoxycycloheximide and a metabolic derangement concomitant with this blockade

1963 • 140 citations

Effects of cycloheximide on polyribosome function in reticulocytes

1967 • 131 citations

The effect of cycloheximide on polyribosomes from hamster cells

1966 • 123 citations

Effect of Cycloheximide on Polysomes and Protein Synthesis in the Mouse Liver^*

1965 • 118 citations

Cycloheximide resistance in yeast: A property of the 60s ribosomal subunit

1967 • 94 citations

PROTEIN CHAIN INITIATION IN RABBIT RETICULOCYTES

1970 • 85 citations

Fusidic Acid: Inhibition of Factor T ₂ in Reticulocyte Protein Synthesis

1969 • 81 citations

The Function of 80 S Ribosomal Subunits and Effects of Some Antibiotics

1969 • 72 citations

Inhibitors of the Transfer of Amino Acids from Aminoacyl Soluble Ribonucleic Acid to Proteins

1965 • 71 citations

Inhibition of protein synthesis in vitro by cycloheximide and related glutarimide antibiotics

1965 • 69 citations

Partial Characterization of the Enzymatic Properties of the Aminoacyl Transfer Ribonucleic Acid Binding Enzyme

1969 • 67 citations

RIBOSOME ACTIVATION AND POLYSOME FORMATION IN VITRO: REQUIREMENT FOR ATP

1966 • 54 citations

The Sequence of Reactions leading to the Synthesis of a Peptide Bond on Reticulocyte Ribosomes

1969 • 54 citations

Initiation of protein synthesis in rabbit reticulocytes

1970 • 52 citations

Deacylated Transfer Ribonucleic Acid as a Factor for Peptide Chain Initiation in Rabbit Reticulocyte Systems

1968 • 48 citations

Initiator tRNA for the synthesis of globin peptides

1970 • 48 citations

EVIDENCE FOR A PROPOSED INITIATION COMPLEX FOR PROTEIN SYNTHESIS IN RETICULOCYTE POLYRIBOSOME PROFILES

1969 • 41 citations

Reactions of N-acetylphenylalanyl transfer RNA with rat-liver ribosomes

1969 • 28 citations

Differential inactivation of soluble reticulocyte transfer factors with N-ethylmaleimide

1966 • 25 citations

DEACYLATED TRNA ^Phe BINDING TO A RETICULOCYTE RIBOSOMAL SITE FOR THE INITIATION OF POLYPHENYLALANINE SYNTHESIS

1969 • 14 citations

Involvement of transfer ribonucleic acid in early reactions of polyphenylalanine synthesis

1968 • 12 citations