Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

PROTOCOLS FOR SCREENING CHEMICAL AGENTS AND NATURAL PRODUCTS AGAINST ANIMAL TUMORS AND OTHER BIOLOGICAL SYSTEMS

1972 • 1,130 citations

UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

1996 • 451 citations

Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.

1970 • 285 citations

Noncompartmental Analysis Based on Statistical Moment Theory

1982 • 274 citations

Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.

1996 • 221 citations

Potential roles for preclinical pharmacology in phase I clinical trials.

1986 • 213 citations

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

1998 • 198 citations

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1987 • 189 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

1997 • 155 citations

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.

1993 • 133 citations

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1993 • 119 citations

UCN-01, 7-Hydroxyl-staurosporine, Inhibits Kinase Activity of Cyclin-Dependent Kinases and Reduces the Phosphorylation of the Retinoblastoma Susceptibility Gene Product in A549 Human Lung Cancer Cell Line

1996 • 117 citations

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

1994 • 92 citations

Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor

1996 • 74 citations

Simple method of hepatic venous blood sampling in the rat

1976 • 46 citations

Application of Pharmacokinetically Guided Dose Escalation With Respect to Cell Cycle Phase Specificity

1994 • 25 citations

Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs

1989 • 25 citations

Cytocidal Action of Anticancer Agents : Evaluation of the Sensitivity of Cultured Animal and Human Cancer Cells

2015 • 24 citations

Development of a highly sensitive high-performance liquid chromatographic method for measuring an anticancer drug, UCN-01, in human plasma or urine

1998 • 14 citations