Macrophages, but not dendritic cells, present collagen to T cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

Hyaluronan ¹

1992 • 1,787 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

1981 • 705 citations

RHEUMATOID ARTHRITIS: A DISEASE OF T-LYMPHOCYTE/MACROPHAGE IMMUNOREGULATION

1981 • 670 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells.

1988 • 565 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

Structural studies on cartilage collagen employing limited cleavage and solubilization with pepsin

1972 • 420 citations

The Structure of the Disaccharide Unit of the Renal Glomerular Basement Membrane

1967 • 333 citations

Two better cell lines for making hybridomas expressing specific T cell receptors.

1989 • 300 citations

Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis.

1982 • 277 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

Induction of autoreactive B cells allows priming of autoreactive T cells.

1991 • 253 citations

Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes.

1986 • 238 citations

Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis.

1989 • 215 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

T cell recognition of carbohydrates on type II collagen.

1994 • 206 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage.

1989 • 196 citations

Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis

1989 • 190 citations

Protein-Specific Helper T-Lymphocyte Formation Initiated by Dendritic Cells

1985 • 181 citations

Epidermal Langerhans Cells

2024 • 172 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

Expression of a transgenic class II Ab gene confers susceptibility to collagen‐induced arthritis

1994 • 160 citations

Hybrid cell lines with T-cell characteristics

1977 • 146 citations

Identification of an immunodominant type‐II collagen peptide recognized by T cells in H‐2^q mice: self tolerance at the level of determinant selection

1992 • 141 citations

T cell recognition of fibrinogen. A determinant on the A alpha-chain does not require processing.

1988 • 100 citations

MHC molecules protect T cell epitopes against proteolytic destruction.

1992 • 87 citations

MHC class II expression by Langerhans' cells and lymph node dendritic cells: possible evidence for maturation of Langerhans' cells following contact sensitization.

1991 • 84 citations

Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC.

1993 • 79 citations

Antigen‐presenting cell function of dendritic cells and macrophages in proliferative T cell responses to soluble and particulate antigens

1986 • 78 citations

Electron microscopic study of HLA‐DR and monocyte/macrophage staining cells in the rheumatoid synovial membrane

1986 • 75 citations

The ability of cultured Langerhans cells to process and present protein antigens is MHC-dependent.

1991 • 66 citations

In vivo modulation of CD1 and MHC class II expression by sheep afferent lymph dendritic cells. Comparison of primary and secondary immune responses.

1989 • 55 citations

Enrichment of Epidermal Langerhans Cells: Studies with a Monolayer Technique and Flow Cytometry Sorting

1982 • 53 citations

Origin of the autoreactive anti-type II collagen response. II. Specificities, antibody isotypes and usage of V gene families of anti-type II collagen B cells.

1989 • 50 citations

Analysis of Type II Collagen Reactive T Cells in the Mouse

1991 • 50 citations

Involvement of Macrophages and Denidritic Cells in Synovial Inflammation of Collagen Induced Arthritis in Dba/1 Mice and Spontaneous Arthritis in Mrl/Lpr Mice

1991 • 37 citations

Delayed Antigen Presentation by Epidermal Langerhans Cells to Cloned T h1 and T h2 Cells

1990 • 7 citations