Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P‐glycoproteins

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

1986 • 321 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Functional Complementation of Yeast ste6 by a Mammalian Multidrug Resistance mdr Gene

1992 • 218 citations

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.

1991 • 212 citations

Cyclosporins as drug resistance modifiers

1992 • 205 citations

P-Glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance

1989 • 179 citations

Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties.

1991 • 149 citations

Nystatin-Resistant Mutants of Yeast: Alterations in Sterol Content

1971 • 136 citations

Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein.

1994 • 127 citations

Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

1990 • 121 citations

Structure of aureobasidin A.

1991 • 95 citations

Functional expression of human P‐glycoprotein in Schizosaccharomyces pombe

1993 • 28 citations

Expression of Human P-Glycoprotein in Yeast Cells. Effects of Membrane Component Sterols on the Activity of P-Glycoprotein.

1991 • 20 citations