Are we mismanaging calcium and phosphate metabolism in renal failure?

Menopausal changes in calcium balance performance

2009 • 518 citations

Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro.

1996 • 512 citations

On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog

1971 • 484 citations

Calcium Carbonate as a Phosphate Binder in Patients with Chronic Renal Failure Undergoing Dialysis

1986 • 389 citations

Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency.

1984 • 360 citations

Calcium balance during human growth: evidence for threshold behavior

1992 • 357 citations

Direct effect of phosphorus on PTH secretion from whole rat parathyroid glands in vitro

1996 • 326 citations

Metabolic balance studies and dietary protein requirements in patients undergoing continuous ambulatory peritoneal dialysis

1982 • 304 citations

Soft tissue calcification in chronic dialysis patients.

1977 • 295 citations

STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM WITH SPECIAL REFERENCE TO PATHOGENESIS AND EFFECTS OF DIHYDROTACHYSTEROL (A.T.10) AND IRON

1943 • 277 citations

Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans.

1986 • 269 citations

AORTIC AND MITRAL VALVE CALCIFICATION IN PATIENTS WITH END-STAGE RENAL DISEASE

1987 • 256 citations

Metabolic studies of renal osteodystrophy. I. Calcium, phosphorus and nitrogen metabolism in rickets, osteomalacia and hyperparathyroidism complicating chronic uremia and in the osteomalacia of the adult Fanconi syndrome.

1962 • 239 citations

2.3 Fluids and Electrolytes

2018 • 239 citations

Phosphorus restriction reverses hyperparathyroidism in uremia independent of changes in calcium and calcitriol

1990 • 222 citations

Hyperparathyroidism and 1,25-Dihydroxyvitamin D Deficiency in Mild, Moderate, and Severe Renal Failure*

1988 • 220 citations

Pulmonary Calcification in Chronic Dialysis Patients

1975 • 216 citations

Study of intestinal absorption of calcium in patients with renal failure

1973 • 209 citations

Increased Ionized Calcium and Left Ventricular Contractility during Hemodialysis

1984 • 208 citations

Parathyroid hormone gene expression in hypophosphatemic rats.

1995 • 203 citations

METABOLIC STUDIES OF RENAL OSTEODYSTROPHY

1962 • 199 citations

Renal toxicity of phosphate in rats

1980 • 191 citations

Calcium and Phosphorus Fluxes During Hemodialysis With Low Calcium Dialysate

1991 • 191 citations

Serum magnesium level and arterial calcification in end-stage renal disease

1987 • 190 citations

Urinary Calcium and Calcium Balance in Young Men as Affected by Level of Protein and Phosphorus Intake

1981 • 184 citations

Left Ventricular Contractility Varies Directly with Blood Ionized Calcium

1988 • 181 citations

Myocardial calcification and cardiac dysfunction in chronic renal failure

1988 • 180 citations

The absorption of dietary phosphorus and calcium in hemodialysis patients

1986 • 174 citations

Absence of Seasonal Variation in Serum Concentrations of 1,25-Dihydroxyvitamin D Despite a Rise in 25-Hydroxyvitamin D in Summer*

1981 • 158 citations

Nature of soft tissue calcification in uremia

1973 • 157 citations

Bioavailability to Rats of Zinc, Magnesium and Calcium in Casein-, Egg- and Soy Protein-Containing Diets

1979 • 146 citations

SECRETION AND EXCRETION OF CALCIUM BY THE HUMAN GASTROINTESTINAL TRACT.

1964 • 142 citations

Phosphate depletion arrests progression of chronic renal failure independent of protein intake

1986 • 138 citations

Cardiac calcification in uremia

1971 • 136 citations

The Effect of a High Intake of Calcium and Phosphate in Normal Subjects and Patients with Chronic Renal Failure

1970 • 136 citations

Calcium kinetics and the long-term effects of lowering dialysate calcium concentration

1993 • 121 citations

Jejunal and ileal adaptation to alterations in dietary calcium: changes in calcium and magnesium absorption and pathogenetic role of parathyroid hormone and 1,25-dihydroxyvitamin D.

1981 • 115 citations

Intestinal Ca and phosphate transport: differential responses to vitamin D3 metabolites.

1977 • 115 citations

Preservation of renal function in experimental glomerulonephritis

1980 • 111 citations

Phosphate kinetics during high-flux hemodialysis.

1993 • 106 citations

Phosphate excess and progressive renal failure: The precipitation-calcification hypothesis

1989 • 98 citations

On the Molecular Mechanism of Intestinal Calcium Transport

1989 • 93 citations

Intestinal absorption of calcium and the effect of renal insufficiency

1973 • 84 citations

THE EFFECT OF FEEDING HIGH AMOUNTS OF SOLUBLE IRON AND ALUMINUM SALTS

1935 • 81 citations

Evidence of healing of secondary hyperparathyroidism in chronically hemodialyzed uremic patients treated with long-term intravenous calcitriol

1994 • 69 citations

Calcific Aortic Stenosis: A Complication of Chronic Uraemia

1987 • 68 citations

Net intestinal absorption of calcium in patients with chronic renal failure

1973 • 67 citations

Metastatic calcification.

1947 • 67 citations

Low-calcium dialysate stimulates parathormone secretion and its long-term use worsens secondary hyperparathyroidism.

1995 • 66 citations

Pulmonary calcification in hemodialyzed patients detected by technetium-99m diphosphonate scanning

1980 • 65 citations

Metastatic calcification of the heart and lungs in end-stage renal disease: detection and quantification by dual-energy digital chest radiography

1987 • 63 citations

The rapid, hormonally stimulated transport of calcium (transcaltachia)

1987 • 56 citations

The effect of a high intake of calcium on magnesium metabolism in normal subjects and patients with chronic renal failure.

1967 • 56 citations

Mitral Valve Calcification as an Index of Left Ventricular Dysfunction in Patients With End-Stage Renal Disease on Peritoneal Dialysis

1994 • 55 citations

Calcium Carbonate as a Phosphate Binder: Is There a Need to Adjust Peritoneal Dialysate Calcium Concentrations for Patients Using CaCO3?

1989 • 55 citations

Calcium absorption in renal failure: its relationship to blood urea nitrogen, dietary calcium intake, time on dialysis, and other variables.

1971 • 54 citations

Calcium carbonate as a phosphate binder: is there a need to adjust peritoneal dialysate calcium concentrations for patients using CaCO3?

1989 • 54 citations

THE EFFECT OF A LARGE INTAKE OF CALCIUM CITRATE IN NORMAL SUBJECTS AND PATIENTS WITH CHRONIC RENAL FAILURE.

1964 • 47 citations

Calbindin-D9k stimulates the calcium pump in rat enterocyte basolateral membranes

1989 • 42 citations

Rickets in rats by iron feeding

1934 • 39 citations

Production and degradation of calcitriol in renal failure rats

1987 • 38 citations

Uremic plasma contains factors inhibiting 1 alpha-hydroxylase activity.

1992 • 36 citations

Myocardial calcification and cardiac dysfunction in chronic renal failure, by SG Rostand, C Sanders, KA Kirk, EA Rutsky, and RG Fraser. Am J Med 85:651-657, 1988

1989 • 36 citations

SERUM CALCIUM AND SERUM PHOSPHORUS IN URAEMIA DURING ADMINISTRATION OF SODIUM PHYTATE AND ALUMINIUM HYDROXIDE

1968 • 35 citations

The effects of high doses of aluminum and iron on phosphorus metabolism.

1931 • 34 citations

Metastatic Pulmonary Calcification Mimicking Air-Space Disease

1994 • 32 citations

Calcitriol Metabolism in Patients With Chronic Renal Failure

1991 • 30 citations

The interrelationship between sodium, calcium, and magnesium excretion in advanced renal failure.

1969 • 30 citations

Hypercalcemia Inhibits the Rapid Stimulatory Effect on Calcium Transport in Perfused Duodena from Normal Chicks Mediatedin Vitroby 1,25-Dihydroxyvitamin D₃^*

1986 • 28 citations

Prevention of phosphate-induced progression of uremia in rats by 3-phosphocitric acid

1982 • 27 citations

Calcium mass transfer in peritoneal dialysis patients using 2.5 mEq/l calcium dialysate.

1992 • 22 citations

Relationship between Degree of Renal Failure and Impairment of Intestinal Calcium Absorption

1976 • 20 citations

Calcium and phosphorus intakes, balances, and blood levels of adults consuming self-selected diets

1984 • 17 citations

The Effect of Ferric Chloride on the Utilization of Calcium and Phosphorus in the Animal Body

1940 • 17 citations

Myocardial texture and cardiac calcification in uremia.

1993 • 16 citations

Phosphate removal during dialysis--does the membrane matter?

1994 • 12 citations

Effects of Dialysis on Myocardial Contractility

2015 • 5 citations

Intracardiac calcification in patients under chronic haemodialysis

1987 • 4 citations