The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

Clinical applications of angiogenic growth factors and their inhibitors

1999 • 1,017 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

2001 • 644 citations

Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression

1999 • 638 citations

Copper stimulates proliferation of human endothelial cells under culture

1998 • 398 citations

Role of prostaglandin E1 and copper in angiogenesis.

1982 • 393 citations

The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene

1994 • 382 citations

TREATMENT OF WILSON'S DISEASE WITH TRIENTINE (TRIETHYLENE TETRAMINE) DIHYDROCHLORIDE

1982 • 369 citations

REHABILITATION IN SCHIZOPHRENIA.

1965 • 341 citations

Platelet endothelial cell adhesion molecule-1 (PECAM-1 / CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development

1994 • 301 citations

Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study.

2000 • 300 citations

Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.

1990 • 230 citations

Ceruloplasmin, Copper Ions, and Angiogenesis<xref ref-type="fn" rid="fn2">2</xref>

1982 • 226 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

1991 • 209 citations

Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis.

1999 • 183 citations

Quantitation of sinusoid-like vessels in hepatocellular carcinoma: Its clinical and prognostic significance.

1997 • 171 citations

Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain tumors

1993 • 168 citations

Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepatectomy.

2000 • 141 citations

The Molecular Basis of Cancer

1996 • 131 citations

Transformed cell lines susceptible or resistant to in vivo surveillance against tumorigenesis

1978 • 122 citations

High Susceptibility to Hepatocellular Carcinoma Development in LEC Rats with Hereditary Hepatitis

1988 • 117 citations

TUMOUR ANGIOGENESIS

1996 • 115 citations

Hepatocellular carcinoma: treatment with a combination therapy of transcatheter arterial embolization and percutaneous ethanol injection.

1991 • 110 citations

Inactivation of human fibroblast growth factor-1 (FGF-1) activity by interaction with copper ions involves FGF-1 dimer formation induced by copper-catalyzed oxidation.

1992 • 108 citations

Characterization and quantification of copper sulfate-induced vascularization of the rabbit cornea.

1988 • 90 citations

Endothelial area as a prognostic indicator for invasive breast carcinoma

1996 • 80 citations

Mechanisms and therapeutic implications of angiogenesis

1996 • 77 citations

Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat brain

1990 • 75 citations

Inhibitory effect of dietary iron deficiency on inductions of putative preneoplastic lesions as well as 8-hydroxydeoxyguanosine in DNA and lipid peroxidation in the livers of rats caused by exposure to a choline-deficient L-amino acid defined diet

1992 • 66 citations

Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepatocellular carcinoma

1995 • 64 citations

The inhibitory effect of copper on DL-ethionine carcinogenesis in rats.

1973 • 62 citations

Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells.

1996 • 61 citations

Anticopper Treatment Inhibits Pseudopodial Protrusion and the Invasive Spread of 9L Gliosarcoma Cells in the Rat Brain

1990 • 59 citations

Molecular Characterization of Recombinant Human Acidic Fibroblast Growth Factor Produced inE. coli: Comparative Studies with Human Basic Fibroblast Growth Factor

1990 • 58 citations

Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride

1996 • 54 citations

Prevention of spontaneous hepatocellular carcinoma in long-evans cinnamon rats with hereditary hepatitis by th administration of d-penicillamine

1993 • 44 citations

Hepatocellular carcinomas with excessive copper accumulation: CT and MR findings.

1991 • 43 citations

Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride

1996 • 42 citations

Heparin-copper biaffinity chromatography of fibroblast growth factors.

1988 • 38 citations

Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats

1999 • 37 citations

Increased 8-Hydroxydeoxyguanosine in Kidney and Liver of Rats Continuously Exposed to Copper

1994 • 29 citations

Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-Penicillamine

1993 • 27 citations

Thalidomide in solid tumors: the London experience.

2000 • 25 citations

Targeting Chemotherapy of Hepatocellular Carcinoma

1987 • 22 citations

Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats

1992 • 22 citations

Construction of retroviral vectors to induce strong hepatoma cell‐specific expression of cytokine genes

1996 • 21 citations

MR Imaging of Hepatocellular Carcinoma

1995 • 13 citations

Effect of copper administration on the incorporation of [3H]-thymidine into the liver DNA of rats stimulated by dimethyl-nitrosamine and diethylnitrosamine

1981 • 11 citations

In vitro and in vivo interactions of D-penicillamine with tumors.

1996 • 8 citations

Hepatocellular carcinoma in sub-Saharan (tropical) Africa.

1991 • 4 citations