Down-Regulation of Endothelial Adhesion Molecules and Leukocyte Adhesion by Treatment with Superoxide Dismutase Is Beneficial in Chronic Immune Experimental Colitis

Adhesion receptors of the immune system

1990 • 6,585 citations

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Clinicopathologic study of dextran sulfate sodium experimental acute colitis

1998 • 1,955 citations

Natalizumab for Active Crohn's Disease

2003 • 815 citations

Oxidant stress and endothelial cell dysfunction

2001 • 802 citations

Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

1996 • 795 citations

Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin

1993 • 540 citations

Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).

1992 • 476 citations

The distribution of blood rheological parameters in the microvasculature of cat mesentery.

1978 • 403 citations

Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease☆☆☆

1998 • 382 citations

Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells.

1997 • 364 citations

Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.

1996 • 349 citations

Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease

1992 • 342 citations

Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse.

1997 • 339 citations

Heterogeneity of Expression of E- and P-Selectins In Vivo

1996 • 312 citations

Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe

1992 • 260 citations

Regional differences in constitutive and induced ICAM-1 expression in vivo

1995 • 254 citations

The reevaluation of the ferric thiocyanate assay for lipid hydroperoxides with special considerations of the mechanistic aspects of the response

1996 • 237 citations

VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis

1999 • 216 citations

A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion.

1995 • 210 citations

Role of reactive oxygen metabolites in experimental colitis.

1990 • 201 citations

Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice

2001 • 201 citations

Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species

2004 • 189 citations

VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice

2000 • 177 citations

Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine

2004 • 173 citations

Lymphocyte Migration Through Monolayers of Endothelial Cell Lines Involves VCAM-1 Signaling Via Endothelial Cell NADPH Oxidase

2000 • 173 citations

A pilot study of treatment of active ulcerative colitis with natalizumab, a humanized monoclonal antibody to alpha‐4 integrin

2002 • 165 citations

Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation

1999 • 150 citations

Determination of volumetric flow in capillary tubes using an optical Doppler velocimeter

1987 • 148 citations

Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway.

1995 • 146 citations

Heparin mobilizes xanthine oxidase and induces lung inflammation in acute pancreatitis

2003 • 142 citations

Differential expression of mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1) in ulcerative colitis and Crohn's disease

2002 • 139 citations

Inhibition of IFN-γ-Inducible Protein-10 Abrogates Colitis in IL-10−/− Mice

2003 • 138 citations

Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts.

1998 • 133 citations

Metabolism of trinitrobenzene sulfonic acid by the rat colon produces reactive oxygen species

1991 • 128 citations

The Effects of Infliximab Maintenance Therapy on Health-Related Quality of Life

2003 • 126 citations

Sp1 Is a Component of the Cytokine-inducible Enhancer in the Promoter of Vascular Cell Adhesion Molecule-1

1995 • 121 citations

Serum amyloid A protein compared with C‐reactive protein, alpha 1‐antichymotrypsin and alpha 1‐acid glycoprotein as a monitor of inflammatory bowel disease

1987 • 97 citations

Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice

2000 • 94 citations

SUPEROXIDE POTENTIATES NF-??B ACTIVATION AND MODULATES ENDOTOXIN-INDUCED CYTOKINE PRODUCTION IN ALVEOLAR MACROPHAGES

2005 • 92 citations

Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy

2002 • 91 citations

Serum Amyloid A Induces Chemotaxis of Human Mast Cells by Activating a Pertussis Toxin-Sensitive Signal Transduction Pathway

1999 • 73 citations

Copper induces apoptosis in BA/F3? cells: Bax, reactive oxygen species, and NF?B are involved

2000 • 70 citations

Serum amyloid A activates NF‐κB and proinflammatory gene expression in human and murine intestinal epithelial cells

2005 • 70 citations

Location of superoxide anion generation in human colonic mucosa obtained by biopsy.

1993 • 63 citations

CYTOKINES MODULATE ENDOTHELIAL CELL INTRACELLULAR SIGNAL TRANSDUCTION REQUIRED FOR VCAM-1-DEPENDENT LYMPHOCYTE TRANSENDOTHELIAL MIGRATION

2001 • 56 citations

Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kB.

2002 • 52 citations

Gene Transfer of Endothelial NO Synthase and Manganese Superoxide Dismutase on Arterial Vascular Cell Adhesion Molecule-1 Expression and Superoxide Production in Deoxycorticosterone Acetate-Salt Hypertension

2002 • 48 citations

Efficacy and safety of a humanized α4β7 antibody in active crohn's disease (CD)

2003 • 45 citations

Quantification of murine endothelial cell adhesion molecules in solid tumors

1999 • 43 citations

TNF-α-induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent

2003 • 43 citations

Portal hypertension enhances endotoxin-induced intercellular adhesion molecule 1 up-regulation in the rat

1996 • 43 citations

Nitric Oxide Supplementation Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice

2002 • 41 citations

ENDOTOXIN-INDUCED MESENTERIC MICROVASCULAR CHANGES INVOLVE iNOS-DERIVED NITRIC OXIDE: RESULTS FROM A STUDY USING iNOS KNOCK OUT MICE

2000 • 29 citations

Effect of prostaglandins and superoxide dismutase administration on oxygen free radical production in experimental acute pancreatitis

1993 • 29 citations

A randomized controlled trial of a humanized Alpha4Beta7 antibody in Ulcerative Colitis (UC)

2003 • 16 citations

CAMs and anti-CAMs. The clinical potential of cell adhesion molecules.

1992 • 12 citations