Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans.

Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats

1963 • 2,254 citations

β-cells in type II diabetes mellitus

1991 • 582 citations

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

1984 • 481 citations

Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins

1989 • 341 citations

Disproportionate elevation of immunoreactive proinsulin in Type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

1987 • 274 citations

Effects of Hemipancreatectomy on Insulin Secretion and Glucose Tolerance in Healthy Humans

1990 • 250 citations

Hyperproinsulinemia and Amyloid in NIDDM: Clues to Etiology of Islet β-Cell Dysfunction?

1989 • 186 citations

Increased β-Cell Secretory Capacity as Mechanism for Islet Adaptation to Nicotinic Acid-Induced Insulin Resistance

1989 • 181 citations

Disproportionately Elevated Proinsulin in Pima Indians with Noninsulin-Dependent Diabetes Mellitus*

1990 • 171 citations

What β-cell Defect Could Lead to Hyperproinsulinemia in NIDDM?: Some Clues From Recent Advances Made in Understanding the Proinsulin-Processing Mechanism

1994 • 152 citations

Potentiation of Insulin Secretory Responses by Plasma Glucose Levels in Man: Evidence That Hyperglycemia in Diabetes Compensates for Impaired Glucose Potentiation*

1979 • 151 citations

Islet Cell and Other Organ-specific Antibodies in U.S. Caucasians and Blacks with Insulin-dependent Diabetes Mellitus

1980 • 141 citations

Proinsulin as a Marker for the Development of NIDDM in Japanese-American Men

1995 • 130 citations

Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors.

1992 • 128 citations

Direct measurement of plasma proinsulin in normal and diabetic subjects

1972 • 101 citations

The Histocompatibility System in Juvenile, Insulin-Dependent Diabetic Multiplex Kindreds

1977 • 98 citations

Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.

1995 • 92 citations

Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states

1974 • 81 citations

Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of Type 1 (insulin-dependent) diabetic patients

1988 • 80 citations

Proinsulin and Specific Insulin Concentration in High- and Low-Risk Populations for NIDDM

1994 • 79 citations

Follow-Up of Women With Previous GDM: Insulin, C-Peptide, and Proinsulin Responses to Oral Glucose Load

1991 • 76 citations

Reduction of Glycemic Potentiation: Sensitive Indicator of β-Cell Loss in Partially Pancreatectomized Dogs

1988 • 74 citations

Islet cell and other organ-specific antibodies in U.S. Caucasians and Blacks with insulin-dependent diabetes mellitus

1980 • 61 citations

Elevated Proinsulin in Healthy Siblings of IDDM Patients Independent of HLA Identity

1989 • 53 citations

Proinsulin as a marker for the development of NIDDM in Japanese-American men

1995 • 49 citations

Raised proinsulin concentration as early indicator of beta cell dysfunction.

1991 • 49 citations

Hyperproinsulinemia of Type II Diabetes Is Not Present Before the Development of Hyperglycemia

1994 • 48 citations

A sensitive radioimmunoassay for human proinsulin, with sequential use of antisera to C-peptide and insulin.

1986 • 36 citations

Effect of Glucocorticoid and Growth Hormone Treatment on Proinsulin Levels in Humans

1993 • 33 citations

Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance

1991 • 32 citations

Elevated Proinsulin Levels Related to Islet Cell Antibodies in First-Degree Relatives of IDDM Patients

1992 • 32 citations

Proinsulin and specific insulin concentration in high- and low-risk populations for NIDDM

1994 • 29 citations

Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors

1994 • 22 citations

Relative hypersecretion of proinsulin in rat model of NIDDM

1991 • 18 citations

Glucose‐induced Insulin Response is Reduced and Proinsulin Response Increased in Healthy Siblings of Type 1 Diabetic Patients

1991 • 18 citations

Inhibition of ATP-Sensitive K+ Channels in Pancreatic β-Cells by Nonsulfonylurea Drug Linogliride

1991 • 16 citations

Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity

1989 • 14 citations

Plasma proinsulin in first-degree relatives of type 2 diabetic subjects.

1990 • 12 citations

Pancreas transplantation

1987 • 11 citations

Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans

1993 • 9 citations

Pancreas Transplantation

1990 • 3 citations

Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors

1994 • 1 citations