Liver Protection from Apoptosis Requires Both Blockage of Initiator Caspase Activities and Inhibition of ASK1/JNK Pathway via Glutathione S-Transferase Regulation
Data up to Jan 2025
Total Citations Per Year
Abstract
References (53)
Cellular survival: a play in three Akts
1999 • 4,229 citations
The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I
1995 • 3,492 citations
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 • 3,241 citations
Regulation of Cell Death Protease Caspase-9 by Phosphorylation
1998 • 3,129 citations
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
1998 • 2,360 citations
Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways
1997 • 2,284 citations
THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS
1998 • 1,982 citations
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
2002 • 1,296 citations
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
2001 • 1,181 citations
Regulation of JNK signaling by GSTp
1999 • 1,102 citations
Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms
1997 • 889 citations
Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death
2001 • 781 citations
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
1999 • 750 citations
Fas-Induced Caspase Denitrosylation
1999 • 742 citations
Human immunodeficiency virus infection modified the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis
1997 • 719 citations
Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1
2001 • 700 citations
Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.
1992 • 675 citations
Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx
1998 • 596 citations
Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions
1971 • 570 citations
Biochemical Characteristics of Caspases-3, -6, -7, and -8
1997 • 536 citations
Inhibition of Fas death signals by FLIPs
1998 • 531 citations
Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation
1997 • 530 citations
Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1
2001 • 397 citations
Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice
1996 • 370 citations
Maintenance of differentiated rat hepatocytes in primary culture.
1985 • 358 citations
Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction
1998 • 351 citations
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins
1999 • 351 citations
Activation of apoptosis signal‐regulating kinase 1 by the stress‐induced activating phosphorylation of pre‐formed oligomer
2002 • 349 citations
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism
2001 • 311 citations
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
2001 • 290 citations
Interleukin-6 Protects against Fas-mediated Death by Establishing a Critical Level of Anti-apoptotic Hepatic Proteins FLIP, Bcl-2, and Bcl-xL
2001 • 282 citations
Culture of Epithelial Cells
2002 • 264 citations
Biochemical and Cellular Mechanisms of Toxic Liver Injury
2002 • 241 citations
Microtubule Dysfunction Induced by Paclitaxel Initiates Apoptosis through Both c-Jun N-terminal Kinase (JNK)-dependent and -Independent Pathways in Ovarian Cancer Cells
1999 • 217 citations
NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun
2002 • 198 citations
Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor
1995 • 184 citations
Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide.
1991 • 180 citations
An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle
1999 • 176 citations
Molecular Mechanisms of the Decision between Life and Death: Regulation of Apoptosis by Apoptosis Signal-Regulating Kinase 1
2001 • 171 citations
Chronic cholestatic diseases
2000 • 152 citations
The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure
1999 • 141 citations
Elevation of the placental glutathione S-transferase form (GST-pi) in tumor tissues and the levels in sera of patients with cancer.
1989 • 106 citations
The Cell Cycle-Regulatory CDC25A Phosphatase Inhibits Apoptosis Signal-Regulating Kinase 1
2001 • 105 citations
Liver apoptosis
1997 • 94 citations
Dexamethasone inhibits spontaneous apoptosis in primary cultures of human and rat hepatocytes via Bcl-2 and Bcl-xL induction
2001 • 75 citations
Tumor necrosis factor-alpha-induced apoptosis in hepatocytes in long-term culture.
1996 • 66 citations
Prevention of acetaminophen-induced hepatotoxicity by dimethyl sulfoxide
1988 • 64 citations
Pro-inflammatory Cytokines Tumor Necrosis Factor α and Interleukin-6 and Survival Factor Epidermal Growth Factor Positively Regulate the Murine GSTA4 Enzyme in Hepatocytes
2002 • 46 citations
Glutathione S-transferases in human liver cancer.
1991 • 45 citations
Changes in expression of mRNA coding for glutathione S-transferase subunits 1-2 and 7 in cultured rat hepatocytes.
1990 • 43 citations
Cationic lipids derived from glycine betaine promote efficient and non‐toxic gene transfection in cultured hepatocytes
2002 • 32 citations
Regulation of glutathione S‐transferase subunits 3 and 4 in cultured rat hepatocytes
1989 • 18 citations
Hepatoprotection by Dimethyl Sulfoxide. I. Protection When Given Twenty-Four Hours After Chloroform or Bromobenzene
1999 • 11 citations