Multiple neuropeptide Y receptors are involved in cardiovascular regulation. Peripheral and central mechanisms

Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide

1982 • 2,244 citations

Neuropeptide Y: complete amino acid sequence of the brain peptide.

1982 • 1,360 citations

Neuropeptide Y (NPY)‐like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function

1982 • 1,206 citations

Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers

1984 • 735 citations

Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides

1986 • 632 citations

Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system—II. Immunohistochemical analysis

1986 • 570 citations

Modulation of Anxiety and Neuropeptide Y-Y1 Receptors by Antisense Oligodeoxynucleotides

1993 • 528 citations

Projections from the nucleus tractus solitarii to the rostral ventrolateral medulla

1985 • 513 citations

Cloned human neuropeptide Y receptor couples to two different second messenger systems.

1992 • 430 citations

Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.

1992 • 429 citations

G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides

1990 • 428 citations

Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels

1984 • 396 citations

[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist.

1990 • 373 citations

Pancreatic polypeptide ? A postulated new hormone: Identification of its cellular storage site by light and electron microscopic immunocytochemistry

1976 • 371 citations

Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions

1974 • 356 citations

Frequency- and reserpine-dependent chemical coding of sympathetic transmission: Differential release of noradrenaline and neuropeptide Y from pig spleen

1986 • 355 citations

Function of the ventrolateral medulla in the control of the circulation

1986 • 334 citations

Neural organisation and control of the baroreceptor reflex

1981 • 331 citations

Central administration of neuropeptide Y induces hypotension bradypnea and EEG synchronization in the rat*

1983 • 292 citations

Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect

1992 • 288 citations

Neuropeptide Y (NPY) depresses the secretion of ³H‐noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens

1984 • 270 citations

Evidence for differential localization of noradrenaline and neuropeptide Y in neuronal storage vesicles isolated from rat vas deferens

1985 • 261 citations

Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction: mode of action.

1985 • 241 citations

Molecular cloning of a novel G protein‐coupled receptor that may belong to the neuropeptide receptor family

1990 • 240 citations

Neuropeptide Y Receptor Subtypes, Y1 and Y2

1990 • 223 citations

Peptide YY (PYY) immunoreactivity is co-stored with glucagon-related immunoreactants in endocrine cells of the gut and pancreas

1984 • 218 citations

Plasma neuropeptide Y‐like immunoreactivity and catecholamines during various degrees of sympathetic activation in man

1986 • 205 citations

Presynaptic inhibition by neuropeptide Y in rat hippocampal slice in vitro is mediated by a Y₂ receptor

1991 • 187 citations

Coexistence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut

1984 • 183 citations

Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY

1992 • 183 citations

Effects of neuropeptide Y on the cardiovascular system

1987 • 183 citations

Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: Neuromodulation by neuropeptide Y?

1985 • 182 citations

Occurrence of neuropeptide Y (NPY)-like immunoreactivity in catecholamine neurons in the human medulla oblongata

1983 • 176 citations

Conformational studies on the pancreatic polypeptide hormone family

1984 • 171 citations

Mechanisms underlying pre‐ and postjunctional effects of neuropeptide Y in sympathetic vascular control

1986 • 160 citations

Analysis of neuropeptide Y-induced feeding: Dissociation of Y1 and Y2 receptor effects on natural meal patterns

1991 • 149 citations

VIP and PHI coexist with an NPY-like peptide in intramural neurones of the small intestine

1984 • 146 citations

Vasoconstrictor effects in vivo and plasma disappearance rate of neuropeptide Y in man

1987 • 133 citations

Neuropeptide Y-like immunoreactivity in perivascular nerve fibres of the guinea-pig

1985 • 133 citations

Norepinephrine and neuropeptide Y: vasoconstrictor cooperation in vivo and in vitro

1990 • 132 citations

Characterization of vascular neuropeptide Y receptors

1992 • 123 citations

The biology of neuropeptide Y and related peptides

1993 • 122 citations

Subcellular storage and axonal transport of neuropeptide Y (NPY) in relation to catecholamines in the cat

1985 • 118 citations

Effects of arterial pH and carbon dioxide on pancreatic exocrine H⁺/HCO^‐₃ secretion and secretin‐dependent translocation of cytoplasmic vesicles in pancreatic duct cells

1988 • 117 citations

Elevation of plasma neuropeptide Y levels in congestive heart failure

1989 • 115 citations

Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study

1986 • 113 citations

Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem.

1991 • 112 citations

Dissociation of the effects of neuropeptide Y on feeding and memory: Evidence for pre- and postsynaptic mediation

1989 • 111 citations

Neuropeptide Y (NPY) reduces field stimulation-evoked release of noradrenaline and enhances force of contraction in the rat portal vein

1985 • 110 citations

Co-release and functional interactions of neuropeptide Y and noradrenaline in peripheral sympathetic vascular control.

1988 • 108 citations

Differences in regional brain concentrations of neuropeptide Y in spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats

1985 • 108 citations

Neuropeptide Y (NPY)-induced suppression of activity in the rat: evidence for NPY receptor heterogeneity and for interaction with α-adrenoceptors

1988 • 102 citations

Plasma neuropeptide Y on admission to a coronary care unit: raised levels in patients with left heart failure

1990 • 102 citations

Signal Epitopes in the Three‐Dimensional Structure of Neuropeptide Y

1990 • 101 citations

Role of Adrenaline Neurons of Ventrolateral Medulla (The C1 Group) in the Tonic and Phasic Control of Arterial Pressure

1984 • 98 citations

Characterization and presynaptic modulation of stimulation-evoked exocytotic co-release of noradrenaline and neuropeptide Y in guinea pig heart

2004 • 90 citations

Neuropeptide Y and peptide YY mediate non-adrenergic vasoconstriction and modulate sympathetic responses in rats

1986 • 88 citations

Distribution and relative abundance of neurons in the pigeon forebrain containing somatostatin, neuropeptide Y, or both

1990 • 87 citations

Neuropeptide Y inhibits the nicotine-mediated release of catecholamines from bovine adrenal chromaffin cells.

1988 • 84 citations

Cardiovascular effects of neuropeptide Y in the nucleus tractus solitarius of rats: Relationship with noradrenaline and vasopressin

1985 • 84 citations

Characterization of neuropeptide Y binding sites in rat cardiac ventricular membranes

1990 • 84 citations

Neuropeptide Y: presence in perivascular noradrenergic neurons and vasoconstrictor effects on skeletal muscle blood vessels in experimental animals and man

1987 • 82 citations

Evidence for two neuropeptide Y receptors mediating vasoconstriction

1991 • 81 citations

Cardiovascular effects of neuropeptide Y in rat brainstem nuclei.

1989 • 80 citations

Centrally truncated and stabilized porcine neuropeptide Y analogs: design, synthesis, and mouse brain receptor binding.

1989 • 79 citations

Plasma Neuropeptide Y Concentration Is Increased After Hemorrhage in Conscious Rats

1987 • 76 citations

Neuropeptide Function in the Gastrointestinal Tract

2019 • 76 citations

Receptors on phaeochromocytoma cells for two members of the PP‐fold family — NPY and PP

1987 • 74 citations

Neuropeptide Y Potentiates Contraction and Inhibits Relaxation of Rabbit Coronary Arteries

1987 • 73 citations

Brain Stem Mechanisms in the Control of Arterial Pressure

1981 • 66 citations

Stress-induced changes of circulating neuropeptide Y in the rat: comparison with catecholamines

1987 • 62 citations

Possible location and function of neuropeptide Y receptor subtypes in the rat mesenteric arterial bed.

1992 • 61 citations

Effects of various neuropeptide Y/peptide YY fragments on electrically‐evoked contractions of the rat vas deferens

1990 • 61 citations

Increased plasma levels of neuropeptide Y-like immunoreactivity and catecholamines in severe hypertension remain after treatment to normotension in man

1991 • 60 citations

Peptide YY: A neuropeptide in the gut. Immunocytochemical and immunochemical evidence

1993 • 58 citations

Blood pressure increases after injection of neuropeptide Y into posterior hypothalamic nucleus

1988 • 58 citations

Sympathoinhibition by A1-noradrenergic neurons is mediated by neurons in the C1 area of the rostral medulla

1985 • 58 citations

Co-existence of neuropeptides and differential inhibition of vasodilator responses by neuropeptide Y in guinea pig uterine arteries

1989 • 57 citations

Long-lasting inhibition of the cardiovascular responses to glutamate and the baroreceptor reflex elicited by neuropeptide Y injected into the nucleus tractus solitarius of the rat

1991 • 57 citations

Characterization of Receptor Types for Neuropeptide Y and Related Peptides

1993 • 57 citations

Release of neuropeptide Y upon haemorrhagic hypovolaemia in relation to vasoconstrictor effects in the pig

1987 • 56 citations

Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D release

1991 • 55 citations

Identification and functional studies of a specific peptide YY-preferring receptor in dog adipocytes.

1992 • 54 citations

Neuropeptides And Their Receptors

1990 • 54 citations

Neuropeptide Y, peptide YY and C‐terminal fragments release histamine from rat peritoneal mast cells

1991 • 53 citations

Suppression by neuropeptide Y of capsaicin‐sensitive sensory nerve‐mediated contraction in guinea‐pig airways

1990 • 52 citations

α2-Adrenoceptor-mediated inhibition of nerve stimulation-evoked release of neuropeptide Y (NPY)-like immunoreactivity in the pithed guinea-pig

1986 • 51 citations

Chapter 18 Neuropeptide Y: coexistence with noradrenaline, Functional implications

1986 • 46 citations

Activation of neuropeptide Y1 and neuropeptide Y2 receptors by substituted and truncated neuropeptide Y analogs: identification of signal epitopes

1993 • 44 citations

Modulation of Neuroeffector Transmission

1986 • 43 citations

Evidence for the co‐storage and co‐release of neuropeptide y and noradrenaline from large dense cored vesicles in sympathetic nerves of the bovine vas deferens

1988 • 43 citations

[Pro34]neuropeptide Y selectively identifies postjunctional-mediated actions of neuropeptide Y in vivo in rats and dogs

1991 • 43 citations

The effects of neuropeptide Y and its fragments upon basal and electrically stimulated ion secretion in rat jejunum mucosa

1990 • 41 citations

C-terminal neuropeptide Y fragments are mast cell-dependent vasodepressor agents

1991 • 39 citations

Possible involvement of neuropeptide Y in sympathetic vascular control of canine skeletal muscle

1988 • 38 citations

Norepinephrine release and neuropeptide Y in medulla oblongata of spontaneously hypertensive rats.

1990 • 37 citations

In Vitro Effects of Neuropeptide Y at the Vascular Neuroeffector Junctiona

1990 • 37 citations

Effects of neuropeptide Y at sympathetic neuroeffector junctions: Existence of Y1- and Y2-receptors

1987 • 34 citations

Effects of neuropeptide Y on the blood pressure response to various vasoconstrictor agents.

1988 • 33 citations

Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea

1988 • 32 citations

C-terminal modifications of neuropeptide Y and its analogs leading to selectivity for the mouse brain receptor over the porcine spleen receptor

1990 • 32 citations

Biphasic blood pressure response to neuropeptide Y in anesthetized rats

1990 • 32 citations

Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man

1988 • 31 citations

Transmitter and Peptide Systems in Areas Involved in the Control of Blood Pressure

1984 • 30 citations

The Brain and Hypertension

1988 • 29 citations

THE SEASONAL VARIATION IN BASAL METABOLISM

1928 • 28 citations

Identification and functional studies of a specific peptide YY- preferring receptor in dog adipocytes

1992 • 28 citations

Further evidence for a prejunctional action of neuropeptide Y on cholinergic motor neurons in the rat uterine cervix

1990 • 25 citations

Unmasking the vasoconstrictor response to neuropeptide Y and its interaction with vasodilating agents in vitro

1992 • 23 citations

Cardiovascular significance of neuropeptide Y in the caudal ventrolateral medulla of the rat

1988 • 23 citations

The role of neuropeptide Y in vascular sympathetic neurotransmission may be enhanced in hypertension

1988 • 22 citations

Coronary constriction due to neuropeptide Y: alleviation with cyclooxygenase blockers

1989 • 22 citations

Higher density of 125I-neuropeptide Y receptors in the area postrema of SHR

1987 • 21 citations

Modulation of Neuroeffector Transmission

1987 • 19 citations

Hypertension

1988 • 18 citations

Increased neuropeptide Y (NPY) receptor binding in hippocampus and cortex of spontaneous hypertensive (SH) rats compared to normotensive (WKY) rats

1986 • 16 citations

Neuropeptide Y suppresses the neurogenic inflammatory response in the rabbit eye; mode of action

1993 • 13 citations

Neuropeptide Y 16–36 inhibits mucociliary activity but does not affect blood flow in the rabbit maxillary sinus in vivo

1992 • 9 citations

Specific alterations in cardiovascular function and in glucose utilisation within lower brainstem nuclei following intracisternal neuropeptide Y in the conscious rat

1990 • 7 citations

Neuropeptide Y and Its C Terminal Fragments Attenuate Anion Secretion in Rat Jejunum Mucosaa

1990 • 1 citations