Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

[Biological psychiatry].

1980 • 1,087 citations

Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat

1971 • 685 citations

Huntington's Disease

1979 • 607 citations

GABA in nervous system function

1976 • 529 citations

Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

1978 • 401 citations

Neurotransmitters, seizures and epilepsy

1982 • 353 citations

Inhibitory, GABAergic Nerve Terminals Decrease at Sites of Focal Epilepsy

1979 • 350 citations

A new class of GABA agonist

1977 • 338 citations

Central neurotransmitters and aging

1980 • 297 citations

Behavioural stimulation induced by muscimol and other GABA agonists injected into the substantia nigra

1977 • 279 citations

The striatal dopaminergic function is mediated by the inhibition of a nigral, non-dopaminergic neuronal system via a strio-nigral gabaergic pathway

1978 • 269 citations

GABA levels in CSF of patients with psychiatric disorders

1980 • 263 citations

Effects of neuroleptics on 3H-haloperidol and 3H-CIS (Z)-flupenthixol binding and on adenylate cyclase activity in vitro

1978 • 261 citations

CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa

1981 • 251 citations

THE CHOLINERGIC SYSTEM IN OLD AGE AND ALZHEIMER'S DISEASE

1980 • 237 citations

Dopamine receptors: Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum

1978 • 203 citations

Subcellular localization of dopamine-sensitive adenylate cyclase and dopamine receptor binding activities

1978 • 198 citations

DIHYDROMUSCIMOL, THIOMUSCIMOL AND RELATED HETEROCYCLIC COMPOUNDS AS GABA ANALOGUES

1979 • 185 citations

Central GABA receptor agonists: Comparison of muscimol and baclofen

1976 • 182 citations

STRUCTURE‐ACTIVITY STUDIES ON THE INHIBITION OF GABA BINDING TO RAT BRAIN MEMBRANES BY MUSCIMOL AND RELATED COMPOUNDS

1978 • 176 citations

GABA receptor binding with 3H (+) bicuculline–methiodide in rat CNS

1977 • 175 citations

γ-AMINOBUTYRIC-ACID DEFICIENCY IN BRAIN OF SCHIZOPHRENIC PATIENTS

1979 • 171 citations

Distribution of high affinity sodium-independent [3H]gamma-aminobutyric acid ([3H]GABA) binding in the human brain: Alterations in Parkinson's disease

1977 • 159 citations

gamma-Aminobutyric acid receptor binding in mammalian brain. Heterogeneity of binding sites.

1981 • 150 citations

GABA Receptor Control of Parasympathetic Outflow to Heart: Characterization and Brainstem Localization

1979 • 145 citations

On the supersensitivity of dopamine receptors, induced by neuroleptics

1976 • 135 citations

EFFECTS OF GABA ANALOGUES OF RESTRICTED CONFORMATION ON GABA TRANSPORT IN ASTROCYTES AND BRAIN CORTEX SLICES AND ON GABA RECEPTOR BINDING

1979 • 133 citations

Inhibitors of the GABA uptake systems

1980 • 131 citations

Analgesic properties of the GABA-minetic thip

1981 • 130 citations

γ-Aminobutyric Acid Receptor Function in Rat Anterior Pituitary: Evidence for Control of Prolactin Release

1979 • 123 citations

Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists

1977 • 121 citations

Amino acids as chemical transmitters

1980 • 120 citations

Distribution of GABA in post-mortem brain tissue from control, psychotic and Huntington's chorea subjects

1980 • 118 citations

The pharmacology of GABA-transaminase inhibitors

1981 • 116 citations

Neurotransmitters, seizures, and epilepsy

1981 • 113 citations

Rotational behaviour after unilateral intranigral injection of muscimol in rats

1977 • 104 citations

MUSCIMOL UPTAKE, RELEASE AND BINDING IN RAT BRAIN SLICES

1978 • 102 citations

The Binding of the GAB A Agonist [³H]THIP to Rat Brain Synaptic Membranes

1982 • 102 citations

Dual y-Aminobutyric Acid Control of Prolactin Secretion in the Rat*

1979 • 100 citations

Cis-3-aminocyclohexanecar☐ylic acid: a substrate for the neuronal GABA transport system

1977 • 76 citations

Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: A complex GABA-dopamine interaction

1978 • 68 citations

Antagonism of Methylphenidate‐Induced Stereotyped Gnawing in Mice

1972 • 67 citations

Muscimol antagonizes morphine hypermotility without potentiation of analgesia

1978 • 52 citations

Effects of central gaba receptor agonism and antagonism on evoked diencephalic cardiovascular responses

1978 • 37 citations

PROCEEDINGS OF THE BRITISH PHARMACOLOGICAL SOCIETY: 30th‐31st March, 1977: UNIVERSITY OF LIVERPOOL COMMUNICATIONS

1977 • 36 citations

[Neuropsychotropic action of a new anti-epileptic agent: depamide].

1966 • 35 citations

[Dipropylacetamide in the treatment of manic-depressive psychosis].

1975 • 28 citations

Interaction between GABA agonists and the cholinergic muscarinic system in rat corpus striatum

1980 • 27 citations

Chapter 5. GABA Agonists and Antagonists

1980 • 25 citations

Long-term Effects of Neuroleptics

1981 • 21 citations

Benzodiazepines potentiate GABA-dopamine stereotyped dependent gnawing in mice

1979 • 20 citations

[Long-term thymoregulative action of Depamide in manic-depressive psychoses].

1971 • 19 citations

Prolonged treatment with the GABA agonist THIP increases dopamine receptor binding more than it changes dopaminergic behaviour in mice

1981 • 8 citations