1-Aminomethylisoquinoline-4-carboxylates as novel dipeptidylpeptidase IV inhibitors

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1993 • 1,119 citations

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

1993 • 1,064 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

1995 • 741 citations

Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects

1995 • 705 citations

Economic Consequences of Diabetes Mellitus in the U.S. in 1997

1998 • 642 citations

Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes.

1998 • 480 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo

1995 • 270 citations

GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans

1989 • 176 citations

Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for Type 2-diabetes

2009 • 142 citations

NVP-DPP728 (1-[[[2-[(5-Cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-pyrrolidine), a Slow-Binding Inhibitor of Dipeptidyl Peptidase IV

1999 • 125 citations

Glucagon-Like Peptide 1 and its Potential in the Treatment of Non-Insulin-Dependent Diabetes Mellitus

1997 • 53 citations

Increased expression of apolipoprotein genes accompanies differentiation in the intestinal cell line Caco-2.

1993 • 48 citations

ISOQUINOLINE-BASED AMINO ACID DERIVATIVES

2000 • 2 citations