Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes.

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1993 • 1,119 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

1995 • 741 citations

Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects

1995 • 705 citations

Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

1998 • 309 citations

Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig

1996 • 291 citations

Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM

1996 • 286 citations

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

1998 • 279 citations

Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide

1998 • 260 citations

Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor

1996 • 248 citations

Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma.

1989 • 177 citations

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.

1997 • 174 citations

Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family.

1992 • 108 citations

Neuropeptide Y and peptide YY: major modulators of gastrointestinal blood flow and function

1991 • 69 citations

The Inhibitory Effect of Glucagon-Like Peptide-1 (7-36)amide on Antral Motility is Antagonized by Its N-Terminally Truncated Primary Metabolite GLP-1 (9-36)amide

1998 • 66 citations

Analysis of the degradation of insulinotropin [GLP-1(7–37)] in human plasma and production of degradation resistant analogs

1992 • 20 citations

Inhibitory effect of PYY on vagally stimulated acid secretion is mediated predominantly by Y1 receptors

1996 • 17 citations

Is CD26/Dipeptidyl Peptidase IV a Really Important Molecule in T Cell Activation of a Certain Rat Strain?

1995 • 10 citations

Enzyme histochemical studies of membrane proteases in rat subfornical organ

1994 • 4 citations