Physiological Role of Peroxisomal Beta-Oxidation

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

1976 • 1,136 citations

Lignoceric acid is oxidized in the peroxisome: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy.

1984 • 344 citations

β Oxidation in Glyoxysomes from Castor Bean Endosperm

1969 • 329 citations

Peroxisomal disorders: A newly recognised group of genetic diseases

1986 • 313 citations

The role of H2O2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors

1973 • 271 citations

Geometrical and positional fatty acid isomers

1979 • 251 citations

Adrenoleukodystrophy: Impaired Oxidation of Very Long Chain Fatty Acids in White Blood Cells, Cultured Skin Fibroblasts, and Amniocytes

1984 • 223 citations

Metabolism of very long-chain monounsaturated fatty acids (22:1) and the adaptation to their presence in the diet.

1982 • 221 citations

Induction of peroxisomal β-oxidation in rat liver by high-fat diets

1980 • 215 citations

Fatty acid oxidation by human liver peroxisomes

1979 • 197 citations

Nutritional Evaluation of Long-Chain Fatty Acids in Fish Oil

1983 • 189 citations

Fatty acid metabolism and its regulation

1984 • 172 citations

Effects of fat content in the diet on hepatic peroxisomes of the rat

1980 • 171 citations

Effects of high-fat diets on hepatic fatty acid oxidation in the rat Isolation of rat liver peroxisomes by vertical-rotor centrifugation by using a self-generated, iso-osmotic, Percoll gradient

1981 • 170 citations

The Induction of Peroxisome Proliferation in Rat Liver by Perfluorinated Fatty Acids, Metabolically Inert Derivatives of Fatty Acids

1985 • 166 citations

Changes in Peroxisomal Fatty Acid Oxidation in the Diabetic Rat Liver

1981 • 163 citations

Chain length specificities of peroxisomal and mitochondrial β-oxidation in rat liver

1979 • 153 citations

Purification and Properties of Carnitine Octanoyltransferase and Carnitine Palmitoyltransferase from Rat Liver1

1983 • 149 citations

Induction of hepatic peroxisome proliferation in nonrodent species, including primates.

1984 • 137 citations

Short-chain fatty acid activation in rat liver a new assay procedure for the enzymes and studies on their intracellular localization

1968 • 137 citations

Chapter 5 Fatty acid oxidation and its regulation

1984 • 129 citations

Peroxisomal β-oxidation enzyme proteins in the Zellweger syndrome

1985 • 128 citations

Peroxisomal oxidation of long chain fatty acids

1979 • 126 citations

Purification and Properties of Rat Liver Acyl-CoA Dehydrogenases and Electron Transfer Flavoprotein1

1981 • 125 citations

Degradation of unsaturated fatty acids in peroxisomes. Existence of a 2,4-dienoyl-CoA reductase pathway.

1981 • 124 citations

PEROXISOMAL βT‐OXIDATION OF LONG FATTY ACIDS: EFFECTS OF HIGH FAT DIETS*

1982 • 113 citations

Chain-length specificities of mitochondrial and peroxisimal β-oxidation of fatty acids in livers of rainbow trout (Salmo gairdneri)

1985 • 109 citations

Nutritional Evaluation of Long-Chain Fatty Acids in Fish Oil

1982 • 109 citations

PEROXISOMES OF ALKANE‐GROWN YEAST FUNDAMENTAL AND PRACTICAL ASPECTS

1982 • 105 citations

Evidence for peroxisomal retroconversion of adrenic acid (22:4(n-6)) and docosahexaenoic acids (22:6(n-3)) in isolated liver cells

1986 • 97 citations

Physiological Role of Peroxisomal β-Oxidation in Liver of Fasted Rats

1980 • 96 citations

Peroxisomal fatty acid oxidation as detected by H2O2 production in intact perfused rat liver

1981 • 89 citations

Peroxisomal fatty acid oxidation in rat and human tissues. Effect of nutritional state, clofibrate treatment and postnatal development in the rat

1986 • 87 citations

The stimulation of erucate metabolism in isolated rat hepatocytes by rapeseed oil and hydrogenated marine oil-containing diets

1979 • 82 citations

Correlation between the cellular level of long-chain acyl-coa, peroxisomal β-oxidation, and palmitoyl-CoA hydrolase activity in rat liver. Are the two enzyme systems regulated by a substrate-induced mechanism?

1985 • 75 citations

The effect of clofibrate-feeding on hepatic fatty acid metabolism

1978 • 74 citations

Implication of a peroxisomal enzyme in the catabolism of glutaryl-CoA

1984 • 74 citations

Peroxisomal effects of phthalate esters in primary cultures of rat hepatocytes

1983 • 65 citations

Fatty acid products of peroxisomal β-oxidation

1980 • 65 citations

Stimulation of microperoxisomal β-oxidation in rat heart by high-fat diets

1983 • 64 citations

A direct comparison between peroxisomal and mitochondrial preferences for fatty-acyl β-oxidation predicts channelling of medium-chain and very-long-chain unsaturated fatty acids to peroxisomes

1984 • 63 citations

Inhibitory effects of some long-chain unsaturated fatty acids on mitochondrial β-oxidation. Effects of streptozotocin-induced diabetes on mitochondrial β-oxidation of polyunsaturated fatty acids

1985 • 57 citations

Differential effects of altered hormonal state on the induction of ACYL-CoA hydrolases and peroxisomal β-oxidation by clofibric acid

1983 • 57 citations

Evidence for a modified pathway of linoleate degradation. Metabolism of 2,4-decadienoyl coenzyme A.

1982 • 57 citations

Effects of marine oil diet on peroxisomes and mitochondria of rat liver. A combined biochemical and morphometric study.

1981 • 55 citations

Epoxide hydrolase activity in isolated peroxisomes of mouse liver

1983 • 54 citations

Long‐chain acyl‐CoA levels in liver from rats fed high‐fat diets: Is it of significance for an increased peroxisomal β‐oxidation?

1984 • 51 citations

A role for 2,4-enoyl-CoA reductase in mitochondrial β-oxidation of polyunsaturated fatty acids. Effects of treatment with clofibrate on oxidation of polyunsaturated acylcarnitines by isolated rat liver mitochondria

1982 • 50 citations

Carnitine octanoyltransferase of mouse liver peroxisomes: Properties and effect of hypolipidemic drugs

1983 • 50 citations

The metabolism of fatty acids in hepatocytes isolated from triiodothyronine-treated rats

1982 • 46 citations

Induction of microsomal stearoyl-CoA desaturation by the administration of various peroxisome proliferators

1983 • 44 citations

Rat Liver Peroxisomes, II. Stimulation of Peroxisomal Fatty-Acid β-Oxidation by Thyroid Hormones

1983 • 41 citations

Glyoxylate cycle in toad urinary bladder: possible stimulation by aldosterone.

1980 • 37 citations

Chain-shortening of erucic acid and microperoxisomal β-oxidation in rat small intestine

1985 • 36 citations

Two components of hormone-evoked calcium release from intracellular stores of pancreatic acinar cells.

1988 • 35 citations

Is there a gloxylate cycle in the liver of the fetal guinea pig?

1980 • 35 citations

Peroxisomal matrix enzymes in zellweger syndrome: Activity and subcellular localization in liver

1985 • 33 citations

3‐Hydroxyacyl‐CoA epimerase is a peroxisomal enzyme and therefore not involved in mitochondrial fatty acid oxidation

1985 • 31 citations

Metabolic changes in fed rats caused by chronic administration of ethyl 2{5(4-chlorophenyl) pentyl}oxirane-2-carboxylate, a new hypoglycaemic compound

1984 • 31 citations

Participation of peroxisomal β-oxidation system in the chain-shortening of a xenobiotic acyl compound

1984 • 31 citations

β-Oxidation of polyunsaturated fatty acids having double bonds at even-numbered positions in isolated rat liver mitochondria

1983 • 30 citations

Factors which can influence β-oxidation by peroxisomes isolated from livers of clofibrate treated rats. some properties of peroxisomal fractions isolated in a self-generated percoll gradient by vertical rotor centrifugation

1982 • 29 citations

Long‐term effects of high‐fat diets on peroxisomal β‐oxidation in male and female rats

1985 • 27 citations

Increased activity of peroxisomal β-oxidation in rat liver caused by ethyl 2{5(4-chlorophenyl)pentyl}-oxiran-2-carboxylate: An inhibitor of mitochondrial β-oxidation

1982 • 25 citations

Hormone-dependent changes in peroxisomal enzyme activity in guinea pig adrenal.

1982 • 25 citations

Increased 4‐enoyl‐CoA reductase activity in liver mitochondria of rats fed high‐fat diets and its effect on fatty acid oxidation and the inhibitory action of pent‐4‐enoate

1980 • 21 citations

Immunocytochemical localization of two peroxisomal enzymes of lipid ?-oxidation in specific granules of rat eosinophils

1983 • 20 citations

Alterations by peroxisome proliferators of acyl composition of hepatic phosphatidylcholine in rats, mice and guinea-pigs. Role of stearoyl-CoA desaturase

1986 • 20 citations

Glucagon and fasting do not activate peroxisomal fatty acid β-oxidation in rat liver

1984 • 15 citations

Peroxisomal fatty acyl-coenzyme A oxidation in chicken liver

1983 • 13 citations

Factors which may be significant regarding regulation of the clofibrate-dependent induction of hepatic peroxisomal β-oxidation and hepatomegaly

1984 • 12 citations

Peroxisomes in the liver of frog, Bombina orientalis.

1984 • 10 citations

Cytochrome P-450 isoenzymes involved in fatty acid metabolism

1985 • 9 citations

Induction of hepatic ornithine decarboxylase by hypolipidemic drugs with hepatic peroxisome proliferative activity

1981 • 7 citations

Stimulation of Hepatic Polyamine Metabolism Following Intraperitoneal Injection of some Dietary Oils

1986 • 1 citations