Brain lysosomal hydrolases: I. Solubilization and electrophoretic behavior of acid hydrolases in nerve-ending and mitochondrial-lysosomal fractions from rat brain. Effects of autolysis, neuraminidase, and storage

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS*

1964 • 18,916 citations

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1955 • 4,109 citations

THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN

1938 • 3,230 citations

HISTOCHEMICAL METHODS FOR ACID PHOSPHATASE USING HEXAZONIUM PARAROSANILIN AS COUPLER

1962 • 1,599 citations

Methods in enzymology, vol. 127

1987 • 1,134 citations

Tay-Sachs Disease: Generalized Absence of a Beta-D- N -Acetylhexosaminidase Component

1969 • 707 citations

CHROMOGENIC SUBSTRATES

1946 • 512 citations

Use of P-Nitrophenylphosphate as the Substrate in Determination of Serum Acid Phosphatase*

1947 • 318 citations

Variation of β‐N‐acetylhexosaminidase‐pattern in Tay‐Sachs disease

1969 • 258 citations

Determination of enzymatic activity in polyacrylamide gels

1969 • 228 citations

Separation and properties of β-galactosidase, β-glucosidase, β-glucuronidase and N-acetyl-β-glucosaminidase from rat kidney

1967 • 192 citations

Comparative studies on the liver sulphatases

1958 • 189 citations

3 Carboxylic Ester Hydrolases

1971 • 179 citations

Intracellular Location and Properties of Bovine Brain Sialidase

1970 • 155 citations

Isolation of β-galactosidase and β-glucosidase from brain

1966 • 149 citations

Lysosomal hydrolases: Conversion of acidic to basic forms by neuraminidase

1971 • 148 citations

Isolation and Relationship of Human Hexosaminidases

1974 • 133 citations

STUDIES OF BRAIN LYSOSOMES—I SUBCELLULAR DISTRIBUTION OF FIVE ACID HYDROLASES, SUCCINATE DEHYDROGENASE AND GANGLIOSIDES IN RAT BRAIN*

1964 • 132 citations

The Metabolism of Glucocerebrosides

1965 • 126 citations

Hydrolysis of phospholipids by a lysosomal enzyme

1967 • 125 citations

Studies on Human β-d-N-Acetylhexosaminidases

1974 • 118 citations

Glycosidases in the Nervous System

1968 • 111 citations

Mucopolysaccharidosis: Secondarily Induced Abnormal Distribution of Lysosomal Isoenzymes

1973 • 110 citations

Purification and Properties of Human α-Galactosidases

1972 • 109 citations

Rat-liver lysosomal β-glucosidase: A membrane enzyme

1968 • 106 citations

Sub-synaptosomal localization of brain particulate neuraminidase

1972 • 99 citations

DISTRIBUTION OF β-GLUCURONIDASE ACTIVITY IN RAT TISSUES EMPLOYING THE NAPHTHOL AS-BI GLUCURONIDE HEXAZONIUM PARAROSANILIN METHOD

1964 • 97 citations

Lysosomal hydrolases as glycoproteins

1970 • 79 citations

Physicochemical modifications of lysosomal hydrolases during intracellular transport

1973 • 73 citations

Studies on the structure-bound sedimentability of some rat liver lysosome hydrolases

1971 • 64 citations

Tay‐sachs disease and related disorders: Fractionation of brain N‐acetyl‐β‐hexosaminidase on DEAE‐cellulose

1970 • 63 citations

Histochemical and Biochemical Study of Synaptic Lysosomes

1968 • 59 citations

he sulphatase of ox liver XVII. Sulphatase A as a glycoprotein

1973 • 50 citations

Evidence of a membrane-bound phospholipase a in rat liver lysosomes

1970 • 49 citations

Autolysis of glycoproteins in rat kidney lysosomes in vitro. Effects on the isoelectric focusing behaviour of glycoproteins, arylsulphatase and β-glucuronidase

1974 • 46 citations

ARYLSULPHATASES IN HUMAN BRAIN: SEPARATION, PURIFICATION, AND CERTAIN PROPERTIES OF THE TWO SOLUBLE ARYLSULPHATASES¹

1971 • 44 citations

Multiple forms of a highly purified β-N-acetylhexosaminidase from hen oviduct

1971 • 34 citations

[49] The isolation of lysosomes from brain

1974 • 30 citations

Isoelectric-focusing behavior of acid hydrolases in rat kidney lysosomes

1975 • 26 citations

Changes in electronegativity of lysosomal hydrolases during intracellular transport

1975 • 26 citations

THE ACTION OF CALF BRAIN SIALIDASE ON GANGLIOSIDES, SIALOGLYCOPROTEINS AND SIALOGLYCOPEPTIDES

1972 • 25 citations

Effect of cations on structure-linked sedimentability of lysosomal hydrolases

1968 • 25 citations

THE EFFECT OF AUTOLYSIS ON THE DISTRIBUTION OF ACID PHOSPHATASE IN RAT BRAIN*

1965 • 24 citations

β-HEXOSAMINIDASES IN THE NERVOUS SYSTEM: THE QUANTITATIVE HISTOCHEMISTRY OF β-GLUCOSAMINIDASE AND β-GALACTOSAMINIDASE IN THE CEREBELLAR CORTEX AND SUBJACENT WHITE MATTER

1970 • 21 citations

STUDIES ON THE CHARACTERIZATION AND LOCALIZATION OF RAT PLACENTAL ESTERASES

1970 • 17 citations

Kinetic properties of three soluble arylsulphatases from ox brain, homogeneous in polyacrylamide gel electrophoresis.

1969 • 17 citations

CHARACTERIZATION AND LOCALIZATION OF ACID HYDROLASE ACTIVITY IN THE SYNAPTOSOMAL FRACTION FROM RAT CEREBRAL CORTEX

1973 • 14 citations

ISOLATION AND CHARACTERIZATION OF SOLUBLE ACIDIC LIPOPROTEINS FROM RAT BRAIN SYNAPTIC VESICLES

1973 • 8 citations

Effect of human cerebral neuraminidase on hexosaminidase A

1974 • 7 citations

Some Observations on the Experimental Production of Acute Neuroaxonal and Synaptosomal Dystrophy

1971 • 5 citations

Lipoprotein subunit of myelin: isolation, characterization, in vitro formation of myelin membranes.

1970 • 2 citations

Brain hexosaminidase and arylsulfatase isoenzymes in normal and vitamin E-deficient rats: an hypothesis for isoenzyme patterns in GM2 gangliosidoses and MLD.

1974 • 2 citations