Peptide Immunization Indicates that CD8+ T Cells are the Dominant Effector Cells in Trinitrophenyl-Specific Contact Hypersensitivity

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.

1996 • 398 citations

Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion.

1990 • 315 citations

Major histocompatibility complex class I‐restricted CD8⁺ T cells and class II‐restricted CD4⁺ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene

1995 • 291 citations

Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines.

1986 • 186 citations

T cell immune responses to haptens. Structural models for allergic and autoimmune reactions

1996 • 175 citations

Cultured Epidermal Langerhans Cells Activate Effector T Cells for Contact Sensitivity

1990 • 105 citations

Development of effector CD8+ T cells in contact hypersensitivity occurs independently of CD4+ T cells.

1997 • 84 citations

Characterization of epitopes recognized by hapten-specific CD4+ T cells.

1995 • 80 citations

Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Cross-reactive TNP-determinants on different peptides.

1992 • 74 citations

Hyporesponsiveness in Contact Hypersensitivity and Irritant Contact Dermatitis in CD4 Gene Targeted Mouse

1996 • 74 citations

Structural complexity of antigenic determinants for class I MHC-restricted, hapten-specific T cells. Two qualitatively differing types of H-2Kb-restricted TNP epitopes.

1993 • 71 citations

Cross‐reactive trinitrophenylated peptides as antigens for class II major histocompatibility complex‐restricted T cells and inducers of contact sensitivity in mice. Limited T cell receptor repertoire

1995 • 69 citations

Altered Hapten Ligands Antagonize Trinitrophenyl-specific Cytotoxic T Cells and Block Internalization of Hapten-specific Receptors

1997 • 50 citations

Peptide-conjugated hapten groups are the major antigenic determinants for trinitrophenyl-specific cytotoxic T cells

1992 • 46 citations

Carrier-independent hapten recognition and promiscuous MHC restriction by CD4 T cells induced by trinitrophenylated peptides.

1997 • 42 citations

MHC Class I+/II− Dendritic Cells Induce Hapten-Specific Immune Responses In Vitro and In Vivo

1997 • 25 citations

Intracellular processing of hapten-modified protein for MHC class I presentation: cytoplasmic delivery by pH-sensitive liposomes

1993 • 23 citations

Carrier‐reactive hapten‐specific cytotoxic T lymphocyte clones originate from a highly preselected T cell repertoire: implications for chemical‐induced self‐reactivity

1995 • 20 citations

Partial agonism and independent modulation of T cell receptor and CD8 in hapten-specific cytotoxic T cells

1998 • 15 citations

Purified MHC class I molecules present hapten-conjugated peptides to TNP/H-2Kb-specific T cell hybridomas

1993 • 14 citations

Cytokine Modulatable Signalling Through Macrophage HLA Class II. 1. IFN-γ Upregulates the Efficiency of Ca2+ Mobilization in Response to Ligation of Macrophage HLA-DP

1997 • 5 citations