Pharmacogenetic and Germline Prognostic Markers of Lung Cancer

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

The Structure of Haplotype Blocks in the Human Genome

2002 • 5,744 citations

Genome-wide association studies for common diseases and complex traits

2005 • 2,844 citations

Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer

2003 • 2,522 citations

Erlotinib in Lung Cancer — Molecular and Clinical Predictors of Outcome

2005 • 1,834 citations

High-resolution haplotype structure in the human genome

2001 • 1,752 citations

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

2008 • 1,696 citations

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

2009 • 1,470 citations

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

2003 • 1,266 citations

How to Interpret a Genome-wide Association Study

2008 • 959 citations

REporting recommendations for tumor MARKer prognostic studies (REMARK)

2006 • 792 citations

Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer.

2002 • 667 citations

ERCC1 and Thymidylate Synthase mRNA Levels Predict Survival for Colorectal Cancer Patients Receiving Combination Oxaliplatin and Fluorouracil Chemotherapy

2001 • 608 citations

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.

1998 • 512 citations

A first-generation linkage disequilibrium map of human chromosome 22

2002 • 412 citations

Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy

1998 • 388 citations

XPD and XRCC1 Genetic Polymorphisms Are Prognostic Factors in Advanced Non—Small-Cell Lung Cancer Patients Treated With Platinum Chemotherapy

2004 • 296 citations

Comprehensive Analysis ofUGT1APolymorphisms Predictive for Pharmacokinetics and Treatment Outcome in Patients With Non–Small-Cell Lung Cancer Treated With Irinotecan and Cisplatin

2006 • 295 citations

Excision Repair Cross-Complementation Group 1 Polymorphism Predicts Overall Survival in Advanced Non-Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy

2004 • 294 citations

Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells

2000 • 265 citations

Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo

2004 • 252 citations

An Epidermal Growth Factor Receptor Intron 1 Polymorphism Mediates Response to Epidermal Growth Factor Receptor Inhibitors

2004 • 243 citations

Pharmacogenetics of ABCG2 and Adverse Reactions to Gefitinib

2006 • 236 citations

Association between polymorphisms of ERCC1 and XPD and survival in non-small-cell lung cancer patients treated with cisplatin combination chemotherapy

2004 • 222 citations

Correlation of CDA, ERCC1, and XPD Polymorphisms with Response and Survival in Gemcitabine/Cisplatin–Treated Advanced Non–Small Cell Lung Cancer Patients

2008 • 204 citations

Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan‐pharmacokinetics and clinical outcome in patients with advanced non‐small cell lung cancer

2007 • 188 citations

SNP discovery in associating genetic variation with human disease phenotypes

2005 • 183 citations

A Single Nucleotide Polymorphism in the MDM2 Gene: From a Molecular and Cellular Explanation to Clinical Effect

2005 • 177 citations

An Analysis of DNA Repair as a Determinant of Survival in Patients With Non-Small-Cell Lung Cancer

2002 • 172 citations

Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients

2006 • 170 citations

Randomized Phase II and Pharmacogenetic Study of Pemetrexed Compared With Pemetrexed Plus Carboplatin in Pretreated Patients With Advanced Non–Small-Cell Lung Cancer

2009 • 152 citations

DNA Repair Gene Polymorphisms Predict Favorable Clinical Outcome in Advanced Non–Small-Cell Lung Cancer

2009 • 149 citations

ERCC1 expression as a molecular marker of cisplatin resistance in human cervical tumor cells

2000 • 143 citations

Epidermal growth factor receptor expression, signal pathway, and inhibitors in non–small cell lung cancer

2002 • 142 citations

Circulating 25-Hydroxyvitamin D, VDR Polymorphisms, and Survival in Advanced Non–Small-Cell Lung Cancer

2008 • 118 citations

The impact of epidermal growth factor receptor gene status on gefitinib‐treated Japanese patients with non‐small‐cell lung cancer

2006 • 117 citations

Epidermal growth factor receptor expression, signal pathway, and inhibitors in non[ndash ]small cell lung cancer

2002 • 116 citations

Polymorphisms in ERCC1 and Grade 3 or 4 Toxicity in Non–Small Cell Lung Cancer Patients

2005 • 114 citations

VEGF Polymorphisms and Survival in Early-Stage Non–Small-Cell Lung Cancer

2008 • 113 citations

Genetic polymorphisms and treatment response in advanced non-small cell lung cancer

2007 • 105 citations

Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib

2007 • 102 citations

Prospective Assessment of XPD Lys751Gln and XRCC1 Arg399Gln Single Nucleotide Polymorphisms in Lung Cancer

2007 • 97 citations

Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients

2009 • 95 citations

Meta-analyses of p53 tumor suppressor gene alterations and clinicopathological features in resected lung cancers.

1999 • 92 citations

Prognostic significance of p53 codon 72 polymorphism in lung carcinomas

1999 • 89 citations

Glutathione S-transferase M1, T1, and P1 polymorphisms and survival among lung cancer patients.

2003 • 86 citations

Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer.

1996 • 84 citations

Genetic variation in the DNA repair genes is predictive of outcome in lung cancer

2007 • 76 citations

Association ofp53codon 72 polymorphism andMDM2SNP309 with clinical outcome of advanced nonsmall cell lung cancer

2008 • 73 citations

Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India

2007 • 72 citations

Effects of excision repair cross-complementation group 1 (ERCC1) single nucleotide polymorphisms on the prognosis of non-small cell lung cancer patients

2009 • 68 citations

Genetic Polymorphisms and Head and Neck Cancer Outcomes: A Review

2008 • 68 citations

Common Genetic Variation in TP53 Is Associated with Lung Cancer Risk and Prognosis in African Americans and Somatic Mutations in Lung Tumors

2007 • 66 citations

Polymorphisms of Vitamin D Receptor and Survival in Early-Stage Non–Small Cell Lung Cancer Patients

2006 • 66 citations

Polymorphisms of EGFR predict clinical outcome in advanced non-small-cell lung cancer patients treated with Gefitinib

2009 • 62 citations

Haplotype Tagging Single Nucleotide Polymorphisms and Association Studies

2003 • 61 citations

Evidence of differential cisplatin-DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines

1993 • 61 citations

XRCC1 polymorphisms and severe toxicity in lung cancer patients treated with cisplatin-based chemotherapy in Chinese population

2008 • 59 citations

MDM2 Polymorphism, Survival, and Histology in Early-Stage Non–Small-Cell Lung Cancer

2007 • 57 citations

Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer

2007 • 53 citations

Correlation of L‐myc RFLP with metastasis, prognosis and multiple cancer in lung‐cancer patients

1992 • 51 citations

Germline Polymorphisms in EGFR and Survival in Patients With Lung Cancer Receiving Gefitinib

2007 • 50 citations

Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy

2008 • 49 citations

The polymorphism and haplotypes of XRCC1 and survival of non–small-cell lung cancer after radiotherapy

2005 • 49 citations

Effect of ERCC1 Polymorphisms and the Modification by Smoking on the Survival of Non-Small Cell Lung Cancer Patients

2006 • 46 citations

The epidermal growth factor receptor intron1 (CA) n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced lung cancer treated with Gefitinib

2007 • 44 citations

p53 Arg72Pro Polymorphism Predicts Survival Outcome in Lung Cancer Patients in Indian Population

2008 • 43 citations

Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients

1996 • 38 citations

EGFR Dinucleotide Repeat Polymorphism as a Prognostic Indicator in Non-small Cell Lung Cancer

2006 • 37 citations

Prognostic significance of folate metabolism polymorphisms for lung cancer

2007 • 34 citations

Matrix Metalloproteinase Polymorphisms and Survival in Stage I Non–Small Cell Lung Cancer

2006 • 33 citations

A Phase II Study of Irinotecan and Carboplatin in Advanced Non-small Cell Lung Cancer with Pharmacogenomic Analysis: Final Report

2006 • 30 citations

Effect of BRCA1 Haplotype on Survival of Non–Small-Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy

2008 • 30 citations

The Association Between Polymorphisms in Glutathione S-Transferase (GSTM1andGSTT1) and Lung Cancer Outcome

2006 • 29 citations

Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population

2008 • 27 citations

Effect of the p53 Codon 72 and Intron 3Polymorphisms on Non-Small Cell Lung Cancer (NSCLC) Prognosis

2008 • 22 citations

CYP2E1 Polymorphism, Cigarette Smoking, p53 Expression, and Survival in Non-small Cell Lung Cancer

2004 • 19 citations

CYP450 polymorphisms predict clinic outcomes to vinorelbine-based chemotherapy in patients with non-small-cell lung cancer

2006 • 17 citations

A Pharmacogenomic Study of Docetaxel and Gemcitabine for the Initial Treatment of Advanced Non-Small Cell Lung Cancer

2007 • 16 citations

Lack of evidence that p53 Arg72Pro influences lung cancer prognosis: An analysis of survival in 619 female patients

2007 • 16 citations

Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients

2008 • 12 citations