Extracting information on folding from the amino acid sequence: Consensus regions with preferred conformation in homologous proteins

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Dominant forces in protein folding

1990 • 3,682 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Atomic structure of the actin: DNase I complex

1990 • 1,897 citations

Hydrophobicity of Amino Acid Residues in Globular Proteins

1985 • 1,168 citations

INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS

1990 • 1,133 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Principles of protein–protein recognition

1975 • 1,028 citations

Nucleation, Rapid Folding, and Globular Intrachain Regions in Proteins

1973 • 826 citations

Structural Characterization of a Partly Folded Apomyoglobin Intermediate

1990 • 708 citations

Folding and association of proteins

1987 • 697 citations

Ion-pairs in proteins

1983 • 687 citations

Protein-folding dynamics

1976 • 626 citations

NMR evidence for an early framework intermediate on the folding pathway of ribonuclease A

1988 • 583 citations

Defining Solution Conformations of Small Linear Peptides

1991 • 528 citations

Determinants of a protein fold

1987 • 498 citations

Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding

1988 • 463 citations

Prediction of protein secondary structure and active sites using the alignment of homologous sequences

1987 • 449 citations

The evolution of α/β barrel enzymes

1990 • 378 citations

Molecular Model-Building by Computer

1966 • 331 citations

Nature of the charged-group effect on the stability of the C-peptide helix.

1985 • 313 citations

MUTATIONAL EFFECTS ON PROTEIN STABILITY

1989 • 311 citations

Helix-coil transition of the isolated amino terminus of ribonuclease

1971 • 310 citations

A salt bridge stabilizes the helix formed by isolated C-peptide of RNase A.

1982 • 284 citations

A peptide model of a protein folding intermediate

1988 • 252 citations

Demonstration by NMR of folding domains in lysozyme

1991 • 246 citations

Rapid formation of secondary structure framework in protein folding studied by stopped‐flow circular dichroism

1987 • 244 citations

The correlation of ribonuclease activity with specific aspects of tertiary structure

1957 • 237 citations

Conformations of folded proteins in restricted spaces

1990 • 231 citations

Prediction of protein backbone conformation based on seven structure assignments

1991 • 193 citations

Secondary structure‐based profiles: Use of structure‐conserving scoring tables in searching protein sequence databases for structural similarities

1991 • 170 citations

Identification of predictive sequence motifs limited by protein structure data base size

1988 • 160 citations

Folding units in globular proteins.

1981 • 141 citations

THE LIMITED DIGESTION OF RIBONUCLEASE WITH PEPSIN

1956 • 136 citations

The tree structural organization of proteins

1978 • 136 citations

Improvements in a secondary structure prediction method based on a search for local sequence homologies and its use as a model building tool

1988 • 119 citations

An analysis of protein folding pathways

1991 • 116 citations

Protein model structure evaluation using the solvation free energy of folding.

1990 • 102 citations

Formation of local structures in protein folding

1989 • 102 citations

Role of a subdomain in the folding of bovine pancreatic trypsin inhibitor

1990 • 94 citations

Formation of Randomly Paired Disulfide Bonds in Des-(121–124)-ribonuclease after Reduction and Reoxidation

1970 • 93 citations

Structure and stability of thermophilic enzymes Studies on thermolysin

1988 • 92 citations

Dynamic Monte Carlo simulations of globular protein folding/unfolding pathways

1990 • 87 citations

Diffusion‐collision model for the folding kinetics of myoglobin

1988 • 73 citations

Location of domains in globular proteins

1981 • 72 citations

Studies on Ribonuclease S

1964 • 64 citations

Characterization of protein folding intermediates

1991 • 63 citations

Buried surface area, conformational entropy, and protein stability

1984 • 59 citations

Solution structure of the 45-residue magnesium ATP-binding peptide of adenylate kinase as examined by 2-D NMR, FTIR, and CD spectroscopy

1988 • 59 citations

Relations between protein sequence and structure and their significance

1990 • 54 citations

Conformation of a T cell stimulating peptide in aqueous solution

1989 • 50 citations

Folding of yeast iso-1-AM cytochrome c

1983 • 47 citations

Folding of thermolysin fragments

1989 • 44 citations

Sesam: A relational database for structure and sequence of macromolecules

1991 • 42 citations

Weak correlation between predictive power of individual sequence patterns and overall prediction accuracy in proteins

1991 • 36 citations

Protein folding

1991 • 35 citations

The complementing fragment-dependent renaturation by enzyme-catalyzed disulfide interchanges of RNase-(1-118) containing non-native disulfide bonds.

1978 • 26 citations