The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program

Chemical Mutagens. Principles and Methods for Their Detection.

1974 • 1,473 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

The induction of micronuclei as a measure of genotoxicity

1983 • 761 citations

An application of Acridine Orange fluorescent staining to the micronucleus test

1983 • 407 citations

Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes

1987 • 394 citations

Clastogen‐induced micronuclei in peripheral blood erythrocytes: The basis of an improved micronucleus test

1980 • 245 citations

Mutagenicity of cosmetics ingredients licensed by the European Communities

1981 • 229 citations

Towards an improved micronucleus test Studies on 3 model agents, mitomycin C, cyclophosphamide and dimethylbenzanthracene

1980 • 172 citations

Statistical analyses for in vitro cytogenetic assays using chinese hamster ovary cells

1986 • 162 citations

Mutagenic and clastogenic properties of 3‐chloro‐4‐(dichloromethyl)‐5‐hydroxy‐2 (5H)‐furanone: A potent bacterial mutagen in drinking water

1987 • 136 citations

Chemical carcinogens a review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox carcinogen data base

1987 • 134 citations

The persistence of micronuclei in peripheral blood erythrocytes: detection of chronic chromosome breakage in mice

1982 • 127 citations

Toward an improved micronucleus test. Studies on 3 model agents, mitomycin C, CPA and dimethylbenzan-thracene

1980 • 115 citations

Mutagenicity of chili extract and capsaicin in short‐term tests

1985 • 114 citations

Statistical analysis and sample‐size determinations for mutagenicity experiments with binomial responses

1983 • 113 citations

Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone marrow

1984 • 109 citations

Sex difference in the micronucleus test

1986 • 109 citations

The persistence of micronucleated erythrocytes in the peripheral circulation of normal and splenectomized Fischer 344 rats: Implications for cytogenetic screening

1984 • 107 citations

Factors affecting the induction of micronuclei at low doses of X-rays, MMS and dimethylnitrosamine in mouse erythroblasts

1978 • 97 citations

Studies on micronuclei time response and on the effects of multiple treatments of mutagens on induction of micronuclei

1981 • 96 citations

Methyl isocyanate: An evaluation of in vivo cytogenetic activity

1987 • 93 citations

Genetic toxicity of dopamine

1983 • 88 citations

An appraisal of predictive tests for carcinogenicity

1982 • 88 citations

Evaluation of the genetic and embryotoxic effects of bis(tri-n-butyltin)oxide (TBTO), a broad-spectrum pesticide, in multiple in vivo and in vitro short-term tests

1987 • 86 citations

Evaluation of the mutagenicity of formaldehyde in mammalian cytogenetic assays in vivo and vitro

1983 • 86 citations

Mutagenicity studies with X-ray-contrast media, analgesics, antipyretics, antirheumatics and some other pharmaceutical drugs in bacterial, Drosophila and mammalian test systems

1979 • 85 citations

In vivo sister chromatid exchange and micronucleus induction studies with 1,3-butadiene in B6C3F1 mice and Sprague-Dawley rats.

1986 • 83 citations

Modifications in the myeloclastogenic effect of benzene in mice with toluene, phenobarbital, 3-methylcholanthrene, Aroclor 1254 and SKF-525A

1984 • 80 citations

Mutagenicity of betel quid and its ingredients using mammalian test systems

1984 • 79 citations

Strain difference in the micronucleus test

1988 • 74 citations

Genetic toxicological testing of some plant flavonoids by the micronucleus test

1981 • 73 citations

Mechanism of benzene toxicity. Effects of benzene and benzene metabolites on bone marrow cellularity, number of granulopoietic stem cells and frequency of micronuclei in mice

1982 • 71 citations

Sex‐related differences in cytogenetic effects of benzene in the bone marrow of swiss mice

1980 • 70 citations

Cytogenetic effects of pesticides

1985 • 69 citations

High-sensitivity in micronucleus induction of a mouse strain (MS)

1982 • 69 citations

How do in vivo mammalian assays compare to in vitro assays in their ability to detect mutagens

1986 • 67 citations

A simple fluorescent staining procedure for micronuclei and RNA in erythrocytes using Hoechst 33258 and pyronin Y

1983 • 64 citations

Genotoxic effects of ethyl acrylate and methyl acrylate in the mouse evaluated by the micronucleus test

1984 • 64 citations

Influence of Cannabinoids on Somatic Cells <i>in vivo</i>

1980 • 64 citations

The bone marrow clastogenicity of eight halogenated benzenes in male NMRI mice

1987 • 62 citations

Induction of cytogenetic damage in rodents after short‐term inhalation of benzene

1986 • 58 citations

Evaluation of chemicals used for drinking water disinfection for production of chromosomal damage and sperm‐head abnormalities in mice

1985 • 58 citations

In vivo and in vitro cytogenetic damage induced by sodium nitrite

1987 • 57 citations

Correlation between the induction of micronuclei in bone marrow by benzene exposure and the excretion of metabolites in urine of CD-1 mice

1986 • 56 citations

Genotoxicity of garlic, turmeric and asafoetida in mice

1984 • 54 citations

Comparison of the effects of 1,2-dimethylhydrazine and cyclophosphamide on micronucleus incidence in bone marrow and colon

1983 • 51 citations

Mutagenicity studies involving aldrin, endosulfan, dimethoate, phosphamidon, carbaryl and ceresan

1980 • 50 citations

A procedure for data analysis of the rodent micronucleus test involving a historical control

1989 • 50 citations

Bleomycin-induced structural chromosomal aberrations in spermatogonia and bone-marrow cells of mice

1980 • 50 citations

In vivo cytogenetic screening methods for mutagens, with special reference to the micronucleus test

1979 • 50 citations

A rapid for cumulative chromosomal damage in mice

1983 • 49 citations

Aneuploidy-inducing chemicals in yeast evaluated by the micronucleus test

1986 • 48 citations

Micronucleus test in bone marrow of mice treated with 1-nitropropane, 2-nitropropane and cisplatin

1987 • 47 citations

Effects of ethylbenzene, toluene, and xylene on the induction of micronuclei in bone marrow polychromatic erythrocytes of mice

1985 • 47 citations

Induction of chromosome damage in mouse bone marrow by benzo[a]pyrene

1982 • 47 citations

The influence of simple aromatics on benzene clastogenicity

1984 • 46 citations

Statistical analysis of the micronucleus test

1984 • 46 citations

Evaluation of the clastogenic action of benzene by oral administration with 2 cytogenetic techniques in mouse and Chinese hamster

1981 • 46 citations

In vivo studies in male mice on the mutagenic effects of inorganic arsenic

1986 • 45 citations

Induction of micronuclei in the mouse

1983 • 44 citations

Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents

1983 • 44 citations

In vivo exposure to plant flavonols

1983 • 43 citations

Genotoxic effects of some organophosphorous pesticides I. Induction of micronuclei in bone marrow cells in rat

1985 • 42 citations

Concomitant observations of UDS in the liver and micronuclei in the bone marrow of rats exposed to cyclophosphamide or 2-acetylaminofluorene

1985 • 42 citations

Differential mutagenic activity of IQ (2-amino-3-methylimidazo[4,5-ƒ]quinoline) in Salmonella typhimurium strains in vitro and in vivo, in Drosophila, and in mice

1985 • 42 citations

Genotoxic Effect of an Environmental Pollutant, Sodium Fluoride, in Mammalianin VivoTest System

1987 • 42 citations

β-carotene as an inhibitor of benzo(a)pyrene and mitomycin C induced chromosomal breaks in the bone marrow of mice

1985 • 42 citations

Slide preparation and sampling as a major source of variability in the mouse micronucleus assay

1986 • 41 citations

Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes

1985 • 40 citations

Non-genotoxicity of 2,4,6-Trinitrotoluene (TNT) to the mouse bone marrow and the rat liver: implications for its carcinogenicity

1985 • 40 citations

Mutagenic effects of combinations of chemical carcinogens and environmental pollutants in mice as shown by the micronucleus test

1982 • 40 citations

Relative genotoxicity of trichloroacetic acid (TCA) as revealed by different cytogenetic assays: bone marrow chromosome aberration, micronucleus and sperm-head abnormality in the mouse

1987 • 40 citations

Species differences in mutagenicity testing: I. Micronucleus and SCE tests in rats, mice, and Chinese hamsters with aflatoxin B1

1986 • 40 citations

Cytogenetic Effects of Lead Acetate on Rat Bone Marrow Cells

1985 • 38 citations

Clastogenic evaluation of cathinone and amphetamine in somatic cells of mice

1987 • 38 citations

Cytogenetic effect of malathion assessed by the micronucleus test

1982 • 38 citations

In vivo cytogenetic studies on mice exposed to ethylene dibromide

1985 • 37 citations

An approach to identifying specialized batteries of bioassays for specific classes of chemicals: Class analysis using mutagenicity and carcinogenicity relationships and phylogenetic concordance and discordance patterns 1. composition and analysis of the overall data base a report of phase II of the U.S. environmental protection agency gene-tox program (MTR 07213)

1987 • 37 citations

Chloracetamide-N-metholol: an example of an in vitro and in vivo clastogen which is non-mutagenic to Salmonella

1985 • 36 citations

Meiotic micronuclei induced by adriamycin in male rats

1983 • 34 citations

Toxic effects on mouse bone marrow caused by inhalation of benzene

1982 • 34 citations

Evaluation of eugenol for mutagenicity by the mouse micronucleus test

1986 • 34 citations

Genotoxicity evaluation of cyclosporin A, a new immunosuppressive agent

1982 • 33 citations

Comparative genotoxicity of adriamycin and menogarol, two anthracycline antitumor agents.

1983 • 32 citations

Micronuclei and other nuclear anomalies induced in various organs by diethylnitrosamine and 7,12-dimethylbenz[a]anthracene

1986 • 32 citations

Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents III. Transplacental micronucleus test in mice

1985 • 31 citations

Mutagenic bioassay of certain pharmacological drugs I. Thiabendazole (TBZ)

1987 • 31 citations

Caffeic acid as an inhibitor of DMBA-induced chromosomal breakage in mice assessed by bone-marrow micronucleus test

1983 • 30 citations

Rates of micronuclei induction in different mouse strains

1986 • 30 citations

Inactivity of methylene chloride in the mouse bone marrow micronucleus assay

1987 • 29 citations

Mutagenicity of acrylonitrile in mouse

1981 • 29 citations

Mutagenicity study of remsen-fahlberg saccharin and contaminants

1980 • 28 citations

Evaluation of nongenotoxic and genotoxic factors modulating the frequency of micronucleated erythrocytes in the peripheral blood of mice

1986 • 28 citations

Re‐evaluation of 1,2‐dimethylhydrazine in the mouse bone marrow micronucleus assay: Observation of a positive response

1987 • 27 citations

The activity of MNNG in the mouse bone marrow micronucleus assay

1987 • 27 citations

Antimutagenic effect of an antioxidant in mammals

1984 • 26 citations

Induction of micronucleated erythrocytes by primary thioamides and their metabolites in the mouse

1987 • 26 citations

Mutagen-sensitive strain of mice

1979 • 25 citations

Screening of the food additive propionic acid for genotoxic properties

1987 • 25 citations

Evaluation of short-term tests for carcinogens: A report of the international programme on chemical safety's collaborative study on in vivo assays

1989 • 25 citations

Micronucleus formation in bone marrow of mice treated with nifurtimox or benznidazole

1985 • 25 citations

Studies on the possible mutagenicity of β-adrenergic blocker drugs

1983 • 24 citations

Benzo(a)pyrene and gamma-radiation-induced genetic damage in mice can be prevented by gamma-linolenic acid but not by arachidonic acid

1985 • 24 citations

Induction of micronuclei by vinyl acetate in mouse bone marrow cells and cultured human lymphocytes

1987 • 24 citations

The transplacental micronucleus test

1980 • 23 citations

Evaluation of nongenotoxic and genotoxic factors modulating the frequency of micronucleated erythrocytes in the peripheral blood of mice

1985 • 23 citations

Genotoxic potential of acephate technical: In vitro and in vivo effects

1985 • 23 citations

Mouse strain differences in the induction of micronuclei by polycyclic aromatic hydrocarbons

1987 • 23 citations

Cytogenetic analysis of human peripheral blood lymphocytes (in vitro) treated with resorcinol

1983 • 23 citations

The evaluation of the epoxide diluent, n‐butylglycidyl ether, in a series of mutagenicity assays

1980 • 22 citations

The cytonucleus test in the rat: a combined metaphase and micronucleus assay

1987 • 22 citations

Re‐evaluation of the need for multiple sampling times in the mouse bone marrow micronucleus assay: Results for DMBA

1987 • 22 citations

Pyridine prevents the clastogenicity of benzene but not of benzo[a]pyrene or cyclophosphamide

1987 • 22 citations

Studies on benzene mutagenesis. I. The micronucleus test

1980 • 22 citations

Sex difference in sensitivity to the cytogenetic effects of ethyl methanesulfonate in mice demonstrated by the micronucleus test

1980 • 22 citations

Evaluation of some formaldehyde-release compounds and other biocides in the mouse micronucleus test

1983 • 21 citations

Comparative study of the genotoxic properties of Eastern and Western U.S. shale oils, crude petroleum, and coal-derived oil

1982 • 21 citations

Chromosomal aberrations and micronuclei induced in rat and mouse bone marrow cells by sodium nitrate

1985 • 20 citations

Styrene and vinyltoluene induce micronuclei in mouse bone marrow

1981 • 20 citations

Effects of diethylstilboestrol-dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo

1985 • 20 citations

The effect of caffeine in the in vivo SCE and micronucleus mutagenicity tests

1986 • 20 citations

Induction of micronuclei in mouse bone-marrow cells by the flavonoid 5,3′, 4′-trihydroxy-3,6,7,8-tetramethoxy-flavone (THTMF)

1983 • 20 citations

Mutagenicity of N-nitrosodiethanolamine and its acetyl derivatives

1981 • 18 citations

Cytogenetic effect of ortho-phenylenediamine in the mouse, Chinese hamster, and Guinea pig and of derivatives, evaluated by the micronucleus test

1980 • 18 citations

Genotoxicity of cocoa examined by microbial and mammalian systems

1982 • 18 citations

Evaluation of the mutagenic potential of the hair dye N-methyl-amino-2-nitro-4-N′,N′-bis-(2-hydroxyethyl)-aminobenzene in a battery consisting of Drosophila and mammalian cytogenetic assays

1983 • 18 citations

Effect of food and water deprivation on the parameters of the mouse bone marrow micronucleus test

1986 • 18 citations

Failure to detect mutagenic effects of anti-tumor alkyl-lysophospholipids

1981 • 18 citations

Cytogenetic studies on 1,1-dichloroethylene and its two isomers in mammalian cells in vitro and in vivo

1987 • 17 citations

Clastogenic effect of Hippeastidine (HIPP) (1,2,3,4,4a,6 hexahydro-10,hydroxy-3,8,9,trimethoxy-5, 10b, ethanophenanthridine)

1986 • 17 citations

Genotoxic potential of an organophosphate insecticide, phosphamidon (Dimecron): An in vivo study in mice

1987 • 17 citations

Increased antimutagenic activity of simple substituted phenols mixed with the hindered phenolic antioxidant dibunol

1986 • 17 citations

In vivo and in vitro cytogenetic effects of the anti-tumor agent amsacrina (AMSA)

1984 • 17 citations

Attempts to induce cytogenetic effects with sulphite in sulphite oxidase-deficient Chinese hamsters and mice

1983 • 17 citations

The micronucleus test with mouse spleen cells

1983 • 16 citations

In vivo and in vitro biological effects of the flame retardants Tris(2,3-dibromopropyl) phosphate and Tris(2-chlorethyl)orthophosphate

1982 • 16 citations

Mutagenic effect of Monocrotophos--an insecticide in mammalian test systems.

1982 • 16 citations

Supplement 2. Proceedings of a symposium: Genotoxic health hazards in the rubber industry || Mutagenicity of rubber additives and curing fumes: Results from five short-term bioassays

1983 • 16 citations

Mutagenic evaluation of propranolol in somatic and germ cells of mice

1986 • 16 citations

Cytogenetic effects of an agricultural antibiotic, captan, on mouse bone marrow and testicular cells

1987 • 16 citations

Mutagenicity testing of quinine with submammalian and mammalian systems

1983 • 15 citations

Comparative mammalian in vitro and in vivo studies on the mutagenic activity of rhodamine WT

1983 • 14 citations

Correlations between embryotoxic and genotoxic effects of phenytoin in mice

1987 • 14 citations

The effect of diphenylhydantoin on the frequency of micronuclei in bone-marrow polychromatic erythrocytes of mice

1984 • 14 citations

Relative distribution of mature erythrocytes, polychromatic erythrocytes (PE) and micronucleated PE on mouse bone-marrow smears: control observations

1987 • 14 citations

Detection of the cytogenetic effect of inhaled aerosols by the micronucleus test

1986 • 14 citations

Mutagenic studies on the insecticide Metasystox-R with different genetic systems

1983 • 14 citations

Preliminary characterization of the mutagenic properties of ‘necatorin’, a strongly mutagenic compound of the mushroom Lactarius necator

1983 • 14 citations

Genetic toxicological testing of some dyes by the micronucleus test

1986 • 14 citations

Evaluation of the anti-inflammatory drug indomethacin, for its genotoxicity in mice

1987 • 13 citations

Effects of fluphenazine hydrochloride on the bonemarrow cells of swiss mice

1981 • 13 citations

Activity of vinyl chloride monomer in the mouse micronucleus assay

1983 • 13 citations

Benzidine and 3,3'-dichlorobenzidine (DCB) induce micronuclei in the bone marrow and the fetal liver of mice after gavage

1987 • 13 citations

Mutagenicity of aflatoxin B1: Observations in vivo and their relation to in vitro activation

1981 • 13 citations

Mutagenicity tests with astemizole in vitro and in vivo

1982 • 12 citations

Mutagenic properties of pirimiphos-methyl in male mice

1986 • 12 citations

Testing natural indigo for genotoxicity

1984 • 12 citations

Genotoxicity of chlordiazepoxide hydrochloride on the bone-marrow cells of swiss mice

1983 • 11 citations

N-Chloropiperidine and calcium hypochlorite: Possible examples of toxicity-dependent clastogenicity in vitro

1987 • 11 citations

Toxicological studies with dithranol and its 10-acyl analogues

1986 • 11 citations

The mutagenic effect of thiram analysed by the micronucleus test and the anaphase-telophase test

1982 • 11 citations

Evaluation of Thimet 10-G for mutagenicity by 4 different genetic systems

1986 • 11 citations

Dithiocarbamate pesticides: Activity of Propineb in the micronucleus test in mice

1984 • 11 citations

Activity of bromochlorodifluoromethane (BCF) in three mutation tests

1985 • 11 citations

Genotoxicity of the antitumor antibiotic CC-1065

1986 • 11 citations

Study of mutagenic activity of troxerutin, a flavonoid derivative

1987 • 10 citations

Effects of pretreatment of male NMRI mice with enzyme inducers or inhibitors on clastogenicity of toluene

1987 • 10 citations

Lack of mutagenic activity of white spirit

1984 • 10 citations

Mutagenicity and carcinogenicity of mono- and diacetyl hydrazine

1984 • 10 citations

The effects of 4CMB, 4HMB and BC in the micronucleus test

1982 • 9 citations

Mutagenicity tests of the antithyroid agent thiamazole. Cytogenetic studies on male mice.

1987 • 9 citations

Mutagenicity evaluation of amino‐oxazoline derivatives using in vitro and in vivo short‐term tests

1983 • 9 citations

Evaluation of genetic toxicity of insecticide phosphamidon using in vitro & in vivo mammalian test systems.

1980 • 8 citations

Cytogenetic effects of trifluoperazine in mice

1987 • 8 citations

Mutagenic evaluation of tolbutamide and glybenclamide on the bone marrow cells of mice

1986 • 7 citations

An evaluation of the mutagenic potential of 2-(2′,4′-diaminophenoxy)ethanol using the micronucleus test

1982 • 7 citations

Bacterial reversion assay and micronucleus test carried out on hydrogenated glucose syrups ‘Malti-Towa’ (powder) and maltitol crystal

1984 • 7 citations

Mutagenicity of Tris(2,3-dibromopropyl) Phosphate in Mammalian Gonad and Bone Marrow Tissue<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 7 citations

An evaluation of the mutagenic potential of cyanamide using the micronucleus test

1984 • 7 citations

Inactivity of glycerol formal in a mouse micronucleus assay: Relationship to its teratogenicity

1986 • 7 citations

Mutagenic evaluation of etintidine (BL-5641), a novel histamine H2-receptor antagonist, using the chromosome aberration test in CHL cells and the micronucleus test in mice

1987 • 6 citations

Lack of mutagenicity of fasciolicides

1985 • 6 citations

The genetic activity of anthramycin, tomaymycin and sibiromycin in bacterial forward‐ and reverse‐mutation assays and in the mouse bone‐marrow micronucleus test

1983 • 6 citations

Mutagenicity evaluation of thioridazine

1983 • 6 citations

4CMB, 4HMB and BC evaluated by the micronucleus test using a multiple sampling method

1982 • 6 citations

Induction of micronuclei in bone marrow cells of mice treated with phenylbutazone.

1980 • 6 citations

Assay of 4CMB, 4HMB and BC by the micronucleus test — Subcutaneous administration

1982 • 6 citations

Density-gradient enrichment of newly-formed mouse erythrocytes

1984 • 6 citations

Studies on the cytogenetic effects of oxydemetonmethyl in the human leukocyte and mouse micronucleus test systems

1980 • 6 citations

Effect of primidone in somatic and germ cells of mice

1986 • 5 citations

Cytosar-induced micronuclei and chromosomal aberrations in mouse bone-marrow cells

1981 • 5 citations

Mutagenic evaluation of tromaril (N-β-phenylethylanthranilic acid), a novel anti-inflammatory drug, using mammalian test systems

1986 • 5 citations

Mutagenicity studies with safrotin in Drosophila melanogaster and mice

1986 • 5 citations

Cytogenetic effects of vaginally administered gossypol in murine bone marrow cells

1987 • 4 citations

4CMB: Investigation of activity in a mouse micronucleus test

1982 • 4 citations

Cytogenetic effects of BC and 4CMB in the mouse evaluated by the micronucleus test

1982 • 4 citations

Absence of mutagenic activity of WHR-1142A, lidamidine hydrochloride, in 4 short-term tests for mutagenic/carcinogenic potential

1983 • 3 citations

Induction of micronuclei in mouse erythrocytes by Cr6+

1983 • 3 citations

In vivo mutagenicity evaluation of domperidone in Drosophila germ cells and rat bone marrow cells

1985 • 2 citations

Mutagenicity tests with a surfactant formulation, toximul MP-8, in Drosophila and mouse bone marrow cells

1981 • 2 citations

Mutagenicity tests with domperidone in vitro and in vivo

1982 • 2 citations

Comparative studies on the mutagenicity of pirenzepine with submammalian/bacterial and mammalian systems

1980 • 2 citations

[Smith-Lemli-Opitz syndrome: evaluation of the correlations between individual traits as an approach to the study of heterogeneity].

1987 • 2 citations

[Preservation of an isolated kidney in normothermic conditions by perfluorotributylamine emulsion perfusion].

1983 • 1 citations