DNA Methylation in Ovarian Cancer

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

1999 • 5,748 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

The essentials of DNA methylation

1992 • 960 citations

DNA methylation and gene activity

1988 • 904 citations

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

1999 • 830 citations

Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.

1999 • 530 citations

Reduced genomic 5-methylcytosine content in human colonic neoplasia.

1988 • 491 citations

Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells

1998 • 408 citations

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.

1999 • 392 citations

Comparative properties of five human ovarian adenocarcinoma cell lines.

1985 • 323 citations

The Xenoestrogen Bisphenol A Induces Growth, Differentiation, and c-fos Gene Expression in the Female Reproductive Tract*

1998 • 307 citations

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

1999 • 298 citations

A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast

1998 • 274 citations

Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.

1998 • 260 citations

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.

1996 • 237 citations

Primary Ovarian Carcinomas Display Multiple Methylator Phenotypes Involving Known Tumor Suppressor Genes

2001 • 204 citations

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells

2000 • 197 citations

Frequent silencing of the GPC3 gene in ovarian cancer cell lines.

1999 • 173 citations

DNA Methyltransferase Is Actively Retained in the Cytoplasm during Early Development

1999 • 171 citations

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

1992 • 165 citations

Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.

1999 • 163 citations

Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.

1999 • 147 citations

Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells

1997 • 146 citations

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1996 • 138 citations

Cloning of a mammalian DNA methyltransferase

1988 • 126 citations

Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies

1987 • 115 citations

Human ovarian surface epithelium in primary culture

1984 • 100 citations

New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase

1996 • 96 citations

Increased DNA Methyltransferase Expression Is Associated with an Early Stage of Human Hepatocarcinogenesis

1997 • 96 citations

Increased DNA methyltransferase expression in leukaemia

1998 • 89 citations

Abnormal methylation of the calcitonin gene in human colonic neoplasms.

1989 • 75 citations

p16/MTS1 inactivation in ovarian carcinomas: High frequency of reduced protein expression associated with hyper-methylation or mutation in endometrioid and mucinous tumors

1998 • 71 citations

Differential Expression of Distinct mRNAs for Ovine Trophoblast Protein-1 and Related Sheep Type I Interferons1

1993 • 57 citations

Regulation of Proliferation and Apoptosis by Epidermal Growth Factor and Protein Kinase C in Human Ovarian Surface Epithelial Cells

1999 • 55 citations

Cloning and analysis of a novel human putative DNA methyltransferase

1998 • 53 citations

The antiestrogen tamoxifen induces c-fos and jun-B, but not c-jun or jun-D, protooncogenes in the rat uterus.

1993 • 46 citations

Biological Implications of the Mechanism of Action of Human DNA (Cytosine-5)methyltransferase

1994 • 45 citations

Differences inp16Gene Methylation and Expression in Benign and Malignant Ovarian Tumors

1999 • 40 citations