Transforming growth factor beta1-induced cell death in preneoplastic foci of rat liver and sensitization by the antiestrogen tamoxifen

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Growth Factors and Cancer

1991 • 2,044 citations

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Liver regeneration: molecular mechanisms of growth control

1990 • 922 citations

Mammary Cancer Induced by a Single Feeding of Polynuclear Hydrocarbons, and its Suppression

1961 • 788 citations

POSSIBLE ASSOCIATION BETWEEN BENIGN HEPATOMAS AND ORAL CONTRACEPTIVES

1973 • 623 citations

The cell biology of transforming growth factor β

1990 • 537 citations

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1992 • 536 citations

Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

1988 • 424 citations

Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

1984 • 369 citations

Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment.

1992 • 344 citations

Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture

1985 • 325 citations

Mechanisms of Apoptosis: Integration of Genetic, Biochemical, and Cellular Indicators

1994 • 320 citations

Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor.

1986 • 317 citations

Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution.

1990 • 311 citations

Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver.

1994 • 274 citations

Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats.

1993 • 268 citations

Tumor promotion in the liver

1985 • 258 citations

Induction of covalent DNA adducts in rodents by tamoxifen.

1992 • 255 citations

DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion.

1990 • 249 citations

Hepatocyte apoptosis: Is transforming growth factor-B1 the kiss of death? Oberhammer FA, Pavelka M, Sharma S, Tietenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc Natl Acad Sci USA 1992;89:5408–5412

1993 • 233 citations

Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture.

1986 • 224 citations

Activin induces cell death in hepatocytes in vivo and in vitro

1993 • 206 citations

Some aspects of the interaction between natural and synthetic female sex hormones and the liver

1970 • 202 citations

Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion.

1987 • 184 citations

Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis

1993 • 173 citations

Preneoplastic significance of hepatic iron–free foci in genetic hemochromatosis: A study of 185 patients

1993 • 167 citations

Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia

1986 • 144 citations

Apoptosis is induced by transforming growth factor-beta 1 within 5 hours in regressing liver without significant fragmentation of the DNA.

1993 • 142 citations

The effect of estrogen and tamoxifen on hepatocyte proliferationin Vivo andin Vitro

1989 • 131 citations

Transforming growth factor beta 1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice.

1991 • 121 citations

Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances

1994 • 116 citations

Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells. A sequential study.

1984 • 115 citations

Induction of apoptosis by transforming growth factor-β1 in the rat hepatoma cell line MCA-RH7777: A possible association with tissue transglutaminase expression

1993 • 113 citations

Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously.

1991 • 99 citations

Active cell death (apoptosis) in liver biology and disease.

1995 • 94 citations

Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver

1988 • 86 citations

Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643

1994 • 79 citations

Hepatic estrogen receptor in human liver disease

1987 • 78 citations

Estradiol receptors in human liver

1978 • 72 citations

Inhibition of proliferation of normal, preneoplastic, and neoplastic rat hepatocytes by transforming growth factor-beta.

1987 • 71 citations

Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol

1994 • 63 citations

Two-stage control of cell proliferation induced in rat liver by alpha-hexachlorocyclohexane.

1977 • 61 citations

A phase II trial of tamoxifen in hepatocellular carcinoma

1990 • 61 citations

Controlled clinical trial of doxorubicin and tamoxifen versus doxorubicin alone in hepatocellular carcinoma.

1987 • 58 citations

Development of resistance to the growth inhibitory effects of transforming growth factor beta 1 during the spontaneous transformation of rat liver epithelial cells.

1991 • 58 citations

Prospective controlled trial with antiestrogen drug tamoxifen in patients with unresectable hepatocellular carcinoma

1992 • 57 citations

Effect of tumor promoting contraceptive steroids on growth and drug metabolizing enzymes in rat liver.

1986 • 49 citations

Response of liver foci in rats to hepatic tumor promoters

1982 • 49 citations

Evidence for the Hormone Dependency of Hepatic Hyperplastic Nodules: Inhibition of Malignant Transformation After Exogenous 17β-Estradiol and Tamoxifen

2007 • 47 citations

Histochemical and biochemical studies on the effect of the prostacyclin derivative iloprost on CCI4-induced lipid peroxidation in rat liver and its significance for hepatoprotection

1989 • 46 citations

Promoting apoptosis

1995 • 40 citations

Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital

1993 • 36 citations

Different inhibition of DNA synthesis by transforming growth factor β and phenobarbital on GST-P-positive and GST-P-negative hepatocytes

1993 • 31 citations

Protooncogenes and growth factors associated with normal and abnormal liver growth

1991 • 27 citations

Enhancement of peroxisomal enzymes, cytochrome P-452 and DNA synthesis in putative preneoplastic foci of rat liver treated with the peroxisome proliferator nafenopin

1993 • 20 citations

[Hepatocellular carcinoma (HCC): the long-term response to tamoxifen. A clinical case report and review of the literature].

1989 • 3 citations