Pyruvate kinase M2 is a phosphotyrosine-binding protein

On the Origin of Cancer Cells

1956 • 12,141 citations

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

2008 • 2,636 citations

ATP citrate lyase inhibition can suppress tumor cell growth

2005 • 979 citations

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

2004 • 951 citations

A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)

2006 • 874 citations

Large-scale phosphorylation analysis of mouse liver

2007 • 720 citations

Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

2001 • 521 citations

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

1998 • 414 citations

The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

2007 • 392 citations

Structural Basis for Tumor Pyruvate Kinase M2 Allosteric Regulation and Catalysis^,

2005 • 387 citations

Genome-scale loss-of-function screening with a lentiviral RNAi library

2006 • 352 citations

Modulation of type M ₂ pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

1999 • 247 citations

Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.

1992 • 209 citations

Nutrient and hormonal regulation of pyruvate kinase gene expression

1998 • 183 citations

Pyruvate kinase type M2: a crossroad in the tumor metabolome

2002 • 159 citations

Pyruvate kinase type M₂ is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus

1988 • 79 citations

Five enzymes of the glycolytic pathway serve as substrates for purified epidermal-growth-factor-receptor kinase

1986 • 71 citations

Phosphorylation of glycolytic and gluconeogenic enzymes by the insulin receptor kinase

1987 • 50 citations