DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

Upstream and downstream of mTOR

2004 • 4,085 citations

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

2005 • 3,045 citations

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

2007 • 2,035 citations

Hypoxia signalling in cancer and approaches to enforce tumour regression

2006 • 1,603 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

2004 • 1,091 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

1997 • 1,057 citations

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

2004 • 951 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

2001 • 849 citations

Hypoxia signalling through mTOR and the unfolded protein response in cancer

2008 • 837 citations

DJ‐1 has a role in antioxidative stress to prevent cell death

2004 • 828 citations

Loss of PTEN facilitates HIF-1-mediated gene expression

2000 • 824 citations

DJ-1, a Novel Oncogene Which Transforms Mouse NIH3T3 Cells in Cooperation withras

1997 • 736 citations

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

2005 • 676 citations

DJ-1, a novel regulator of the tumor suppressor PTEN

2005 • 532 citations

Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity

2005 • 526 citations

5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

2006 • 431 citations

DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism

2003 • 409 citations

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

2007 • 398 citations

Hypoxia Up-Regulates Hypoxia-Inducible Factor-1α Transcription by Involving Phosphatidylinositol 3-Kinase and Nuclear Factor κB in Pulmonary Artery Smooth Muscle Cells

2007 • 392 citations

Direct Interactions between HIF-1α and Mdm2 Modulate p53 Function

2003 • 323 citations

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

2008 • 315 citations

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

2001 • 309 citations

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

2001 • 286 citations

FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2

2007 • 260 citations

PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)

2008 • 208 citations

Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation.

2001 • 175 citations

YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia

2007 • 161 citations

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage

2007 • 154 citations

Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62

2008 • 149 citations

Pathological properties of the Parkinson?s disease-associated protein DJ-1 in a-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick?s disease

2004 • 149 citations

DJ‐1 colocalizes with tau inclusions: A link between parkinsonism and dementia

2003 • 142 citations

The VHL tumor suppressor and HIF: insights from genetic studies in mice

2008 • 135 citations

p53 Initiates Apoptosis by Transcriptionally Targeting the Antiapoptotic Protein ARC

2007 • 109 citations

Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma

2007 • 109 citations

The hypoxic tumor microenvironment and gene expression

2004 • 105 citations

DJ-1 Binds Androgen Receptor Directly and Mediates Its Activity in Hormonally Treated Prostate Cancer Cells

2007 • 94 citations

Akt and Hypoxia-Inducible Factor-1 Independently Enhance Tumor Growth and Angiogenesis

2004 • 86 citations

Hypoxia confers protection against apoptosis via PI3K/Akt and ERK pathways in lung cancer cells

2006 • 70 citations

Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: Role of Na+/K+ ATPase

2006 • 51 citations

The mTOR Signaling Network: Insights from Its Role During Embryonic Development

2008 • 31 citations