Metabolic activation of the nephrotoxic haloalkene 1, 1, 2-trichloro-3, 3, 3-trifluoro-1-propene by glutathione conjugation

Fluorine in Organic Chemistry

2004 • 1,052 citations

Bioactivation of foreign compounds

1985 • 733 citations

Spektroskopische Methoden in der organischen Chemie

2016 • 717 citations

Fluorine in Organic Chemistry

1974 • 300 citations

Biosynthesis and biotransformation of glutathioneS-Conjugates to toxic metabolites

1988 • 193 citations

The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity

1984 • 192 citations

A purified cysteine conjugate beta-lyase from rat kidney cytosol. Requirement for an alpha-keto acid or an amino acid oxidase for activity and identity with soluble glutamine transaminase K.

1986 • 153 citations

Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.

1986 • 147 citations

Spektroskopische Methoden in der organischen Chemie

1982 • 145 citations

Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity.

1984 • 135 citations

Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane.

1986 • 122 citations

The inhibition of γ-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(αS, 5S)-α-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

1980 • 120 citations

The acute toxic effects of hexachloro-1 : 3-butadiene on the rat kidney

1979 • 113 citations

The rich mechanistic world of nucleophilic vinylic (S_NV) substitution

1985 • 103 citations

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen.

1982 • 89 citations

Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation.

1987 • 82 citations

Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate .beta.-lyase

1988 • 81 citations

Uptake of the glutathione conjugate S-(1,2-dichlorovinyl)glutathione by renal basal-lateral membrane vesicles and isolated kidney cells.

1985 • 79 citations

Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates

1987 • 71 citations

The role of mitochondrial matrix enzymes in the metabolism and toxicity of cysteine conjugates.

1988 • 71 citations

Thioacylating agents as ultimate intermediates in the β-lyase catalysed metabolism of S-(pentachlorobutadienyl)-L-cysteine

1988 • 43 citations

The inhibition of gamma aminobutyric-alpha-ketoglutaric acid transaminase in vitro and in vivo by amino-oxyacetic acid

1960 • 40 citations

Enzymatic conjugation of hexachloro-1,3-butadiene with glutathione. Formation of 1-(glutathion-S-yl)-1,2,3,4,4-pentachlorobuta-1,3-diene and 1,4-bis(glutathion-S-yl)-1,2,3,4-tetrachlorobuta-1,3-diene.

1988 • 40 citations

Toxicology of the fluoroalkenes: Review and research needs

1977 • 37 citations

[16] Preparation and characteristics of isolated kidney cells

1981 • 37 citations