Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates

Revised methods for the Salmonella mutagenicity test

1983 • 7,295 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro

1978 • 247 citations

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

1986 • 208 citations

The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity

1984 • 192 citations

Renal processing of glutathione conjugates

1984 • 171 citations

Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chlgro and fluoroalkenes

1985 • 154 citations

Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity.

1984 • 135 citations

Bacterial β-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene

1986 • 133 citations

Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane.

1986 • 122 citations

Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: A possible explanation for its nephrocarcinogenicity in male rats

1986 • 116 citations

Macromolecular binding and metabolism of the carcinogen 1,2-dibromoethane.

1978 • 114 citations

The metabolism and nephrotoxicity of tetrafluoroethylene in the rat

1984 • 107 citations

The absolute asymmetry of orientation of gamma-glutamyltranspeptidase and aminopeptidase on the external surface of the rat renal brush border membrane.

1980 • 100 citations

Effect of the organic acid transport inhibitor probenecid on renal cortical uptake and proximal tubular toxicity of hexachloro-1,3-butadiene and its conjugates*1

1985 • 98 citations

Identification of S‐1,2,2‐trichlorovinyl‐N‐acetylcysteine as a urinary metabolite of tetrachloroethylene: Bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity

1986 • 91 citations

Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugation

1979 • 82 citations

Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene.

1985 • 77 citations

Glutathione-mediated binding of dibromoalkanes to DNA: specificity of rat glutathione-S-transferases and dibromoalkane structure

1984 • 76 citations

Renal catabolism of glutathione. Characterization of a particulate rat renal dipeptidase that catalyzes the hydrolysis of cysteinylglycine.

1982 • 73 citations

In vivoandin vitronephrotoxicity of the cysteine conjugate of hexachlorobutadiene

1983 • 56 citations

The enzymatic reaction of chlorotrifluoroethylene with glutathione

1982 • 44 citations

Mercapturic acid formation is an activation and intermediary step in the metabolism of hexachlorobutadiene

1986 • 42 citations

Purification and characterization of a rat liver enzyme catalyzing N-deacetylation of mercapturic acid conjugates.

1981 • 35 citations

Methylthlolated Metabolites

1983 • 35 citations

Mutagenicity of the mercapturic acid and other S-containing derivatives of hexachloro-1,3-butadiene

1986 • 18 citations