Immune Reconstitution following Stem Cell Transplantation

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

1992 • 1,227 citations

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

1996 • 852 citations

Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease

1991 • 686 citations

Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution

2000 • 597 citations

A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers

1999 • 520 citations

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8⁺T Lymphocytes in Healthy Seropositive Donors

2000 • 438 citations

Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation

2001 • 436 citations

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

1998 • 434 citations

Memory CD4+ T cells do not induce graft-versus-host disease

2003 • 426 citations

A potential role for interleukin-7 in T-cell homeostasis

2001 • 415 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping: correlation with immune status

1995 • 400 citations

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation

2001 • 399 citations

T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation

2001 • 327 citations

Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix.

1995 • 305 citations

IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation

2001 • 302 citations

Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation

2001 • 302 citations

Interleukin-7: master regulator of peripheral T-cell homeostasis?

2001 • 290 citations

Tetramer-based quantification of cytomegalovirus (CMV)–specific CD8+ T lymphocytes in T-cell–depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection

2001 • 290 citations

Tetrameric HLA class I–minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

1999 • 277 citations

Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation

2002 • 268 citations

Recovery of immune reactivity after T-cell–depleted bone marrow transplantation depends on thymic activity

2000 • 258 citations

Reconstitution of NK cell receptor repertoire followingHLA-matched hematopoietic cell transplantation

2003 • 256 citations

Genetic Control of Human NK Cell Repertoire

2002 • 249 citations

Recovery of immune reactivity after T-cell–depleted bone marrow transplantation depends on thymic activity

2000 • 231 citations

Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count

1999 • 225 citations

Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study

2002 • 225 citations

Reconstitution of the T-Cell Compartment After Bone Marrow Transplantation: Restoration of the Repertoire by Thymic Emigrants

1998 • 223 citations

Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease

2001 • 212 citations

A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation

2002 • 205 citations

Beyond six colors: A new era in flow cytometry

2003 • 202 citations

Minimal residual disease is more common in patients who have mixed T- cell chimerism after bone marrow transplantation for chronic myelogenous leukemia

1994 • 183 citations

Molecular detection and in vivo analysis of the specific T cell response to a protein antigen

1992 • 176 citations

The Umbilical Cord Blood αβ T-Cell Repertoire: Characteristics of a Polyclonal and Naive but Completely Formed Repertoire

1998 • 164 citations

Sensitive detection of human cytomegalovirus peptide–specific cytotoxic T-lymphocyte responses by interferon-γ–enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation

2002 • 163 citations

T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events

2002 • 163 citations

Direct evidence for new T-cell generation by patients after either T-cell–depleted or unmodified allogeneic hematopoietic stem cell transplantations

2002 • 163 citations

T-cell recovery in adults and children following umbilical cord blood transplantation

2001 • 140 citations

Cytomegalovirus‐Specific Cellular Immune Responses and Viremia in Recipients of Allogeneic Stem Cell Transplants

2001 • 132 citations

Interleukin 7 worsens graft-versus-host disease

2002 • 125 citations

Molecular analysis of T cell repertoires

1995 • 115 citations

Longitudinal monitoring of immune reconstitution by CDR3 size spectratyping after T-cell–depleted allogeneic bone marrow transplant and the effect of donor lymphocyte infusions on T-cell repertoire

2000 • 105 citations

Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantation1

2002 • 95 citations

Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma

2002 • 91 citations

Effect of granulocyte colony-stimulating factor mobilization on phenotypical and functional properties of immune cells

2001 • 88 citations

Identification and monitoring of graft-versus-host specific T-cell clone in stem cell transplantation

2003 • 81 citations

Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation

2000 • 77 citations

Conversion to full donor chimerism following donor lymphocyte infusion is associated with disease response in patients with multiple myeloma

2000 • 69 citations

Reconstitution of the Epstein-Barr virus–specific cytotoxic T-lymphocyte response following T-cell–depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation

2003 • 62 citations

EFFECTIVE DEPLETION OF ALLOREACTIVE LYMPHOCYTES FROM PERIPHERAL BLOOD MONONUCLEAR CELL PREPARATIONS1,2

1999 • 61 citations

Factors affecting antibody levels after allogeneic hematopoietic cell transplantation

2003 • 60 citations

Reconstitution of T-cell repertoire after autologous stem cell transplantation: Influence of CD34 selection and cytomegalovirus infection

2003 • 54 citations

T‐ and B‐cell immune reconstitution and clinical outcome in patients with multiple myeloma receiving T‐cell‐depleted, reduced‐intensity allogeneic stem cell transplantation with an alemtuzumab‐containing conditioning regimen followed by escalated donor lymphocyte infusions

2003 • 50 citations

Early reconstitution of the T‐cell repertoire after non‐myeloablative peripheral blood stem cell transplantation is from post‐thymic T‐cell expansion and is unaffected by graft‐versus‐host disease or mixed chimaerism

2003 • 49 citations

Ig Heavy Chain Third Complementarity Determining Regions (H CDR3s) After Stem Cell Transplantation Do Not Resemble the Developing Human Fetal H CDR3s in Size Distribution and Ig Gene Utilization

1998 • 48 citations

Reconstitution of thymic function after stem cell transplantation in humans

2002 • 47 citations

Vbeta spectratype analysis reveals heterogeneity of CD4+ T-cell responses to minor histocompatibility antigens involved in graft-versus-host disease: Correlations with epithelial tissue infiltrate

2001 • 43 citations

Prolonged secretion of IL-15 in patients with severe forms of acute graft-versus-host disease after allogeneic bone marrow transplantation in children.

1998 • 40 citations

Influence of the hematopoietic stem cell source on early immunohematologic reconstitution after allogeneic transplantation

2001 • 33 citations

Distinct TCRAV and TCRBV repertoire and CDR3 sequence of T lymphocytes clonally expanded in blood and GVHD lesions after human allogeneic bone marrow transplantation

2002 • 32 citations

Assessing diversity: immune reconstitution and T‐cell receptor BV spectratype analysis following stem cell transplantation

2002 • 32 citations

Allogeneic peripheral blood stem cell transplantation results in less alteration of early T cell compartment homeostasis than bone marrow transplantation

2001 • 32 citations

Reconstitution of the B cell repertoire after bone marrow transplantation does not recapitulate human fetal development

1999 • 29 citations

Infiltrating T cells during liver graft-versus-host disease show a restricted T-cell repertoire

2000 • 24 citations

Improvements in Repertoire Analysis by CDR3 Size Spectratyping

1995 • 24 citations

British Journal of Haematology

2003 • 23 citations

Natural killer cells: biology and application in stem-cell transplantation

2002 • 23 citations

G‐CSF enhances the immunoglobulin generation rather than the proliferation of human B lymphocytes

1993 • 22 citations

Delayed recovery of CDR3 complexity of the T-cell receptor-β chain in recipients of allogeneic bone marrow transplants who had virus-associated interstitial pneumonia: Monitor of T-cell function by CDR3 spectratyping

2000 • 20 citations

In vitro T‐cell receptor Vβ repertoire analysis may identify which T‐cell Vβ families mediate graft‐versus‐leukaemia and graft‐versus‐host responses after human leucocyte antigen‐matched sibling stem cell transplantation

2001 • 20 citations

Blood versus marrow hematopoietic allogeneic graft

2003 • 18 citations

Extensive clonal expansion of T lymphocytes causes contracted diversity of complementarity-determining region 3 and skewed T cell receptor repertoires after allogeneic hematopoietic cell transplantation

2001 • 16 citations

Bone Marrow Transplantation

2003 • 13 citations

Longitudinal analysis of T cells responding to tetanus toxoid in healthy subjects as well as in pediatric patients after bone marrow transplantation: the identification of identical TCR–CDR3 regions in time suggests long-term stability of at least part of the antigen-specific TCR repertoire

2001 • 11 citations

Exploiting graft-versus-tumour responses using donor leukocyte infusions

2001 • 7 citations