Oxidative Ionic Metabolites of L-Methyl-4-Phenyl-L, 2, 3, 6-Tetrahydropy-Ridine (MPTP): Correlation of Electro-Reduction with Physiological Behavior

Electrochemical Methods: Fundamentals and Applications

1980 • 22,457 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Free radicals in biology and medicine

1985 • 2,999 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

The importance of free radicals and catalytic metal ions in human diseases

1985 • 939 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

Advances in Organic Chemistry

1965 • 768 citations

Paraquat: model for oxidant-initiated toxicity.

1984 • 556 citations

DRUG-INDUCED HEMOLYTIC ANEMIA

1959 • 265 citations

Metabolic activation and drug toxicity

1982 • 204 citations

V. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 148 citations

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with diethyldithiocarbamate

1985 • 129 citations

Parkinson's Disease: An Environmental Cause?

1985 • 62 citations

New amphibian models for the study of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 56 citations

Effect of metal ions on the electrochemical reduction of benzil in non-aqueous solvents

1976 • 54 citations

A catalyst function for MPTP in superoxide formation

1985 • 49 citations

Characterization of the dimeric one-electron electrolytic reduction products of 1-alkylpyridinium ions in acetonitrile

1978 • 44 citations

The Chemistry of Enamines

1973 • 39 citations

Brain Enzyme Is the Target of Drug Toxin

1984 • 36 citations

Role of reactive oxygen and metabolite binding in drug toxicity

1982 • 36 citations

The generation of potentially toxic, reactive iminium ions from the oxidative metabolism of xenobiotic N-alkyl compounds

1985 • 35 citations

Charge Transfer in the Mechanism of Drug Action Involving Quinoxaline Di-N-oxides

1985 • 31 citations

NOTES ON A FEW PYRIDINE ALKYL IODIDES.

1896 • 15 citations

Polarographic reduction of benzazolylsubstituted pyridinium salts

1975 • 9 citations

Mechanism of nucleophilic substitution of hydrogen in azines IV. Role of one-electron transfer in reactions with arylamines

1977 • 3 citations