Pathomechanisms in celiac disease

Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').

1992 • 1,994 citations

Gluten, major histocompatibility complex, and the small intestine

1992 • 1,597 citations

Structural Basis for Gluten Intolerance in Celiac Sprue

2002 • 1,536 citations

Transglutaminases: crosslinking enzymes with pleiotropic functions

2003 • 1,379 citations

Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease

1998 • 1,158 citations

Coeliac disease: dissecting a complex inflammatory disorder

2002 • 948 citations

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

1989 • 923 citations

Coordinated Induction by IL15 of a TCR-Independent NKG2D Signaling Pathway Converts CTL into Lymphokine-Activated Killer Cells in Celiac Disease

2004 • 809 citations

Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma

2000 • 729 citations

A Direct Role for NKG2D/MICA Interaction in Villous Atrophy during Celiac Disease

2004 • 724 citations

Coeliac disease

2003 • 715 citations

The prolamin storage proteins of cereal seeds: structure and evolution

1990 • 691 citations

The Intestinal T Cell Response to α-Gliadin in Adult Celiac Disease Is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase

2000 • 640 citations

Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease

2003 • 605 citations

HLA susceptibility genes in celiac disease: Genetic mapping and role in pathogenesis

1993 • 603 citations

Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients.

1993 • 599 citations

In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope

2000 • 571 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

Sensitivity of Antiendomysium and Antigliadin Antibodies in Untreated Celiac Disease: Disappointing in Clinical Practice

1999 • 535 citations

Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity.

1998 • 487 citations

The first large population based twin study of coeliac disease

2002 • 457 citations

Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease

2003 • 449 citations

The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides

2002 • 412 citations

Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease

2004 • 407 citations

Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity

1998 • 406 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Abnormal intestinal intraepithelial lymphocytes in refractory sprue

1998 • 393 citations

The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses

2003 • 370 citations

Specificity of Tissue Transglutaminase Explains Cereal Toxicity in Celiac Disease

2002 • 364 citations

Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

2001 • 362 citations

Protein Crosslinking in Assembly and Remodelling of Extracellular Matrices: The Role of Transglutaminases

2000 • 314 citations

Identification of a Gliadin T‐Cell Epitope in Coeliac Disease: General Importance of Gliadin Deamidation for Intestinal T‐Cell Recognition

1998 • 271 citations

Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease

2000 • 258 citations

Transglutaminase 2^-/-mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells

2003 • 251 citations

Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis

1999 • 250 citations

Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin

1998 • 243 citations

Gliadin T Cell Epitope Selection by Tissue Transglutaminase in Celiac Disease

2002 • 229 citations

Genome Search in Celiac Disease

1998 • 210 citations

Glutenin is involved in the gluten-driven mucosal T cell response

1999 • 208 citations

[46] Transglutaminases

1985 • 202 citations

T cells from the small intestinal Mucosa of a DR4, DQ7/DR4. DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8

1994 • 187 citations

HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease.

1983 • 182 citations

Numbers of T cell receptor (TCR) alpha beta+ but not of TcR gamma delta+ intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet.

1993 • 178 citations

An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland

1996 • 175 citations

Tissue transglutaminase: a possible role in neurodegenerative diseases

2000 • 170 citations

Intestinal T-cell responses to high-molecular-weight glutenins in celiac disease

2003 • 147 citations

Genetic contribution of the HLA region to the familial clustering of coeliac disease

1997 • 145 citations

A major non-HLA locus in celiac disease maps to chromosome 191 1This study is dedicated to the memory of Lodewijk Sandkuijl (1953–2002), who died shortly after its completion. He was an inspiration to us and was a world expert on biostatistics.

2003 • 144 citations

A comparison of 13 guinea pig and human anti-tissue transglutaminase antibody ELISA kits

2002 • 142 citations

Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA‐DQ (α1*0501, (β1*02) or the HLA‐DQ (α1*03, (β1*0302) heterodimers

1997 • 137 citations

The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders

2000 • 133 citations

CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family‐based association study

1999 • 129 citations

Fibroblasts and transforming growth factor beta induce organization and differentiation of T84 human epithelial cells

1996 • 109 citations

Genomewide Linkage Analysis of Celiac Disease in Finnish Families

2002 • 105 citations

Genetic contribution of the HLA region to the familial clustering of coeliac disease

1997 • 97 citations

IL-15-Dependent Activation-Induced Cell Death-Resistant Th1 Type CD8αβ+NK1.1+ T Cells for the Development of Small Intestinal Inflammation

2002 • 95 citations

Existence of a genetic risk factor on chromosome 5q in Italian Coeliac Disease families

2001 • 92 citations

Celiac Disease Association with CD8+ T Cell Responses: Identification of a Novel Gliadin-Derived HLA-A2-Restricted Epitope

2003 • 92 citations

A genome‐wide family‐based linkage study of coeliac disease

2000 • 91 citations

Factors associated with serum antibodies to reticulin, endomysium, and gliadin in an adult population.

1996 • 74 citations

Coeliac disease: follow‐up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11

2001 • 50 citations

Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.

2002 • 49 citations

Preliminary results from follow-up of a large-scale population survey of antibodies to gliadin, reticulin and endomysium

1996 • 47 citations

Increased Density of Jejunal γδ⁺T Cells in Patients Having Normal Mucosa - Marker of Operative Autoimmune Mechanisms?

1999 • 46 citations

Genome‐wide linkage analysis for celiac disease in North American families

2002 • 43 citations

Transglutaminases - Possible Drug Targets in Human Diseases

2004 • 40 citations

Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci

2004 • 36 citations

Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease

2002 • 34 citations

A Genomewide Screen in a Four-Generation Dutch Family with Celiac Disease: Evidence for Linkage to Chromosomes 6 and 9

2004 • 30 citations

Antibody and genetic testing in coeliac disease

2003 • 28 citations

Coeliac Disease: Previous Family Studies

1981 • 27 citations

"Tissue" transglutaminase in animal development.

2000 • 26 citations

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