Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Leukocyte Typing II

1986 • 688 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3

1987 • 453 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

1986 • 387 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens.

1981 • 338 citations

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen).

1985 • 285 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

Use of Monoclonal Anti-mouse Immunoglobulin to Detect Mouse Antibodies

1981 • 252 citations

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

1987 • 228 citations

Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells.

1985 • 218 citations

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells.

1987 • 194 citations

A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes.

1986 • 191 citations

Identification and functional characterization of two distinct epitopes on the human T cell surface protein Tp50.

1983 • 171 citations

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

1986 • 166 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

A common pathway for T lymphocyte activation involving both the CD3-Ti complex and CD2 sheep erythrocyte receptor determinants.

1986 • 163 citations

T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells.

1985 • 147 citations

Monoclonal antibodies to the CD5 antigen can provide the necessary second signal for activation of isolated resting T cells by solid-phase-bound OKT3.

1986 • 144 citations

Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex.

1985 • 142 citations

Transmembrane signalling via the T11‐dependent pathway of human T cell activation. Evidence for the involvement of 1,2‐diacylglycerol and inositol phosphates

1987 • 137 citations

Cross-linking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes.

1987 • 136 citations

Cross‐linking of the T cell receptor complex with the subset‐specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells

1987 • 117 citations

CD5 antibodies increase intracellular ionized calcium concentration in T cells.

1987 • 92 citations

Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

1986 • 89 citations

Comodulation of CD3 and CD4. Evidence for a specific association between CD4 and approximately 5% of the CD3:T cell receptor complexes on helper T lymphocytes.

1988 • 89 citations

A 45‐kDa human T‐cell membrane glycoprotein functions in the regulation of cell proliferative responses

1984 • 84 citations

Evidence for an association between CD8 molecules and the T cell receptor complex on cytotoxic T cells.

1987 • 83 citations

Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation.

1987 • 71 citations

A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus

1987 • 68 citations

Antigen-specific T cell activation results in an increase in cytoplasmic free calcium.

1985 • 66 citations

Stimulation of T Cells Through the CD3/T-Cell Receptor Complex: Role of Cytoplasmic Calcium, Protein Kinase C Translocation, and Phosphorylation of pp60^c-src in the Activation Pathway

1987 • 66 citations

Activation of T cells by cross‐linking an anti‐CD3 antibody with a second anti‐T cell antibody: mechanism and subset‐specific activation

1987 • 64 citations

Covalent association between human thymus leukemia-like antigens and CD8(Tp32) molecules.

1985 • 62 citations

Antigen recognition by a human T cell clone leads to increases in inositol trisphosphate.

1987 • 60 citations

Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway.

1987 • 46 citations

An immunoglobulin light chain dimer with cd4 antigen specificity

1987 • 26 citations

OH Radicals in Radiation Sensitization

1972 • 25 citations

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