The use of methotrexate in childhood rheumatic diseases

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1993 • 658 citations

Methotrexate for Rheumatoid Arthritis

1994 • 612 citations

Methotrexate in Resistant Juvenile Rheumatoid Arthritis

1992 • 577 citations

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1985 • 460 citations

Effects of Treatment on Fertility in Long-Term Survivors of Childhood or Adolescent Cancer

1987 • 438 citations

Reversible Lymphomas Associated with Epstein-Barr Virus Occurring during Methotrexate Therapy for Rheumatoid Arthritis and Dermatomyositis

1993 • 421 citations

Pretransplantation Assessment of the Risk of Lymphoproliferative Disorder

1995 • 391 citations

Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases.

1996 • 371 citations

Methotrexate and histologic hepatic abnormalities: A meta-analysis

1991 • 350 citations

COMPARISON OF METHOTREXATE WITH PLACEBO IN THE TREATMENT OF SYSTEMIC SCLEROSIS: A 24 WEEK RANDOMIZED DOUBLE-BLIND TRIAL, FOLLOWED BY A 24 WEEK OBSERVATIONAL TRIAL

1996 • 344 citations

Molecular therapeutics. Methotrexate and its mechanism of action

1996 • 266 citations

Methotrexate induced liver cirrhosis

1980 • 259 citations

Intrinsic and Acquired Resistance to Methotrexate in Acute Leukemia

1996 • 249 citations

Outcome of first-trimester exposure to low-dose methotrexate in eight patients with rheumatic disease

1990 • 227 citations

Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients: Association with hepatic folate deficiency and formation of polyglutamates

1986 • 216 citations

Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate.

1991 • 203 citations

Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.

1996 • 200 citations

Pregnancy outcome following cancer chemotherapy

1980 • 193 citations

Lymphoid neoplasms in patients with rheumatoid arthritis and dermatomyositis: Frequency of Epstein-Barr virus and other features associated with immunosuppression

1994 • 185 citations

Multiple congenital anomalies associated with weekly low‐dose methotrexate treatment of the mother

1997 • 153 citations

Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis of ten cases.

1992 • 151 citations

Pregnancy after cytotoxic chemotherapy for gestational trophoblastic tumours.

1984 • 149 citations

Pharmacokinetics of oral methotrexate in children.

1983 • 129 citations

Hematologic malignancies and the use of methotrexate in rheumatoid arthritis: A retrospective study

1995 • 126 citations

TREATMENT OF DERMATOMYOSITIS WITH METHOTREXATE

1968 • 123 citations

Hodgkin's Disease and Lymphoproliferations Resembling Hodgkin's Disease in Patients Receiving Long-Term Low-Dose Methotrexate Therapy

1996 • 114 citations

Morbidity associated with long-term methotrexate therapy in juvenile rheumatoid arthritis

1992 • 112 citations

Complications of immunosuppression associated with weekly low dose methotrexate.

1991 • 104 citations

Toxicity and serum levels of methotrexate in children with juvenile rheumatoid arthritis

1989 • 103 citations

Pharmacokinetics of subcutaneous methotrexate.

1988 • 99 citations

Safety and efficacy of methotrexate therapy for juvenile rheumatoid arthritis

1990 • 97 citations

Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.

1993 • 94 citations

Trial of intravenous pulse cyclophosphamide and methylprednisolone in the treatment of severe systemic‐onset juvenile rheumatoid arthritis

1997 • 90 citations

Effects of methotrexate on radiologic progression in juvenile rheumatoid arthritis

1993 • 89 citations

Methotrexate and Azathioprine Treatment of Childhood Dermatomyositis

1977 • 89 citations

Low-dose methotrexate therapy for childhood sarcoidosis

1997 • 89 citations

Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms

1976 • 87 citations

Methotrexate and fertility in men

1979 • 87 citations

Methotrexate‐associated lymphoma in patients with rheumatoid arthritis. Report of two cases

1996 • 83 citations

Methotrexate therapy in juvenile rheumatoid arthritis: A retrospective study

1986 • 79 citations

Methotrexate treatment of recalcitrant childhood dermatomyositis

1992 • 78 citations

Studies on Human Semen in Topical Corticosteroid-Treated and in Methotrexate-Treated Psoriatics

1977 • 77 citations

Evaluation of methotrexate in the treatment of juvenile chronic arthritis according to the subtype.

1991 • 73 citations

Immunosuppressive agents in corticosteroid‐refractory childhood dermatomyositis

1980 • 65 citations

Comparison of the Relative Mutagenic Activity for Eight Antineoplastic Drugs in the Ames Salmonella/Microsome and TK+/− Mouse Lymphoma Assays

1978 • 57 citations

Preliminary report of higher dose methotrexate treatment in juvenile rheumatoid arthritis.

1992 • 57 citations

High dose methotrexate in the treatment of refractory juvenile rheumatoid arthritis.

1995 • 57 citations

Treatment of Uveitis with Methotrexate

1969 • 56 citations

Methotrexate‐associated appearance and rapid progression of rheumatoid nodules in systemic‐onset juvenile rheumatoid arthritis

1997 • 56 citations

Repetitive use of pulse therapy with methylprednisolone and cyclophosphamide in addition to oral methotrexate in children with systemic juvenile rheumatoid arthritis--preliminary results of a longterm study.

1992 • 54 citations

Central nervous system involvement in systemic lupus erythematosus: a new therapeutic approach with intrathecal dexamethasone and methotrexate

1994 • 53 citations

Methotrexate in juvenile rheumatoid arthritis

1995 • 53 citations

Immunosuppressive Drugs in the Management of Progressive, Corticosteroid-Resistant Uveitis Associated with Juvenile Rheumatoid Arthritis

1992 • 52 citations

Methotrexate therapy in childhood systemic lupus erythematosus.

1993 • 50 citations

Influence of food on the bioavailability of oral methotrexate in children.

1995 • 50 citations

Plasma levels after oral methotrexate in children with juvenile rheumatoid arthritis.

1993 • 50 citations

Low-dose methotrexate in systemic onset juvenile chronic arthritis.

1989 • 49 citations

Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis

1996 • 46 citations

Childhood Dermatomyositis and Polymyositis

1979 • 45 citations

Frequency of relapse after discontinuation of methotrexate therapy for clinical remission in juvenile rheumatoid arthritis.

1995 • 41 citations

Liver biopsy findings in patients with juvenile rheumatoid arthritis receiving long-term, weekly methotrexate therapy

1996 • 40 citations

Hepatic fibrosis with the use of methotrexate for juvenile rheumatoid arthritis.

1990 • 40 citations

Predicting remission in juvenile rheumatoid arthritis with methotrexate treatment.

1993 • 40 citations

Methotrexate in systemic lupus erythematosus.

1994 • 38 citations

Non-Hodgkin's lymphoma in patients with rheumatoid arthritis treated with low dose methotrexate.

1996 • 38 citations

Pilot investigation of naproxen/methotrexate interaction in patients with juvenile rheumatoid arthritis.

1993 • 35 citations

Methotrexate in nonrenal lupus and undifferentiated connective tissue disease--a review of 36 patients.

1996 • 35 citations

Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis

1995 • 28 citations

Hepatic methotrexate content and progression of hepatic fibrosis: preliminary findings.

1991 • 28 citations

Quantitative liver function in patients with rheumatoid arthritis treated with low-dose methotrexate: a longitudinal study

1997 • 28 citations

Factors associated with response to methotrexate in systemic‐onset juvenile chronic arthritis

1994 • 27 citations

Accelerated nodulosis in a patient with psoriasis and arthritis during treatment with methotrexate.

1995 • 26 citations

METHOTREXATE IN THE TREATMENT OF CHILDREN WITH CHRONIC ARTHRITIS — LONG‐TERM OBSERVATIONS OF EFFICACY AND SAFETY

1996 • 25 citations

Intestinal pseudo-obstruction as an initial presentation of systemic sclerosis in two children

1997 • 24 citations

Prospectively measured red cell folate levels in methotrexate treated patients with rheumatoid arthritis: relation to withdrawal and side effects.

1997 • 22 citations

Properdin Factor B (Bf) as an Exclusion Determinate in Parentage Testing

1980 • 15 citations

Early development of Hodgkin's lymphoma in association with the use of methotrexate for the treatment of dermatomyositis.

1995 • 14 citations

Folinic acid supplementation in patients with juvenile rheumatoid arthritis treated with methotrexate.

1996 • 13 citations

Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells

1996 • 8 citations

Rheumatoid nodules and cyclosporin A treatment.

1994 • 6 citations

Adventures in clinical chemistry.

1960 • 4 citations

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