G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

1995 • 714 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

PH domain: the first anniversary

1994 • 318 citations

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

1995 • 317 citations

Role of phosphorylation in desensitization of the β-adrenoceptor

1990 • 300 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase

1995 • 278 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.

1995 • 222 citations

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

1994 • 218 citations

Characterization of the G Protein-coupled Receptor Kinase GRK4

1996 • 193 citations

Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor

1996 • 175 citations

Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases

1996 • 170 citations

Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C

1995 • 160 citations

Structural and functional relationships of heterotrimeric G‐proteins

1995 • 160 citations

High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.

1992 • 123 citations

Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing

1993 • 111 citations

Phosphorylation of the N-Formyl Peptide Receptor Carboxyl Terminus by the G Protein-coupled Receptor Kinase, GRK2

1995 • 108 citations

Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2.

1995 • 106 citations

Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.

1987 • 103 citations

Inhibition of G Protein-coupled Receptor Kinase Subtypes by Ca2+/Calmodulin

1996 • 102 citations

Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart.

1995 • 102 citations

Structure and Expression of Novel Spliced Leader RNA Genes in Caenorhabditis elegans

1995 • 102 citations

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase

1993 • 96 citations

Chronic Morphine Administration Increases β‐Adrenergic Receptor Kinase (βARK) Levels in the Rat Locus Coeruleus

1994 • 94 citations

Agonist-dependent Phosphorylation and Desensitization of the Rat A3 Adenosine Receptor

1995 • 90 citations

Structure and functions of arrestins

1994 • 86 citations

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.

1994 • 85 citations

Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization.

1994 • 80 citations

Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.

1994 • 70 citations

Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases.

1995 • 68 citations

Involvement of G Protein-coupled Receptor Kinase 5 in Homologous Desensitization of the Thyrotropin Receptor

1996 • 65 citations

Arresting G-protein coupled receptor activity

1993 • 53 citations

GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response.

1996 • 42 citations

Rapid desensitization of neonatal rat liver beta-adrenergic receptors. A role for beta-adrenergic receptor kinase.

1994 • 41 citations

Two Isoforms of G Protein-Coupled Receptor Kinase 4 Identified by Molecular Cloning

1994 • 36 citations

Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase

1993 • 29 citations

Characterization and Chromosomal Localization of the Gene for Human Rhodopsin Kinase

1996 • 27 citations

GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor- stimulated response

1996 • 22 citations

ATP-stimulated tetraethylammonium transport by rabbit renal brush border membrane vesicles.

1993 • 16 citations

Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6

1995 • 16 citations

Assignment of the β-Arrestin 1 Gene (ARRB1) to Human Chromosome 11q13

1994 • 12 citations