RETRACTED: 5‐Lipoxygenase antagonizes genotoxic stress‐induced apoptosis by altering p53 nuclear trafficking

Surfing the p53 network

2000 • 6,487 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

The p53 pathway

1999 • 1,322 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

2002 • 1,009 citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 • 809 citations

p53

2000 • 785 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

2001 • 670 citations

The Role of PML in Tumor Suppression

2002 • 552 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

1998 • 498 citations

Ex vivo expansion, adipogenesis and neurogenesis of cryopreserved human bone marrow mesenchymal stem cells

2006 • 426 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Regulation of p53 activity in nuclear bodies by a specific PML isoform

2000 • 371 citations

Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases ¹

1995 • 275 citations

Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis

2002 • 246 citations

Tumor Necrosis Factor-α Generates Reactive Oxygen Species via a Cytosolic Phospholipase A2-linked Cascade

2000 • 238 citations

Cyclooxygenase‐2 and 5‐lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy

2003 • 220 citations

Lipoxygenase-5 is overexpressed in prostate adenocarcinoma

2001 • 216 citations

p53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis

2002 • 215 citations

Five‐lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions

2001 • 209 citations

Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis.

1990 • 191 citations

5-Lipoxygenase and Leukotriene B4 Receptor Are Expressed in Human Pancreatic Cancers But Not in Pancreatic Ducts in Normal Tissue

2002 • 182 citations

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

2002 • 177 citations

Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors.

1999 • 149 citations

5‐Lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor

2001 • 132 citations

Methionine Aminopeptidase-2 Regulates Human Mesothelioma Cell Survival

2001 • 82 citations

Intracellular Compartmentalization of Leukotriene Biosynthesis

2000 • 81 citations

Determinants of 5-Lipoxygenase Nuclear Localization Using Green Fluorescent Protein/5-Lipoxygenase Fusion Proteins

1998 • 62 citations

Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen

2002 • 60 citations

Wild-Type p53 Gene Transfer Inhibits Invasion and Reduces Matrix Metalloproteinase-2 Levels in p53-Mutated Human Melanoma Cells

2000 • 46 citations

Experimental therapy of malignant mesothelioma: new perspectives from anti-angiogenic treatments

2004 • 18 citations

Cell cycle checkpoint status in human malignant mesothelioma cell lines: response to gamma radiation

2003 • 16 citations