5-Lipoxygenase and Leukotriene B4 Receptor Are Expressed in Human Pancreatic Cancers But Not in Pancreatic Ducts in Normal Tissue

Cancer statistics, 2000

2000 • 3,907 citations

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

2001 • 3,629 citations

Cancer statistics, 1996

1996 • 1,807 citations

Progression model for pancreatic cancer.

2000 • 853 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 • 692 citations

Identification and isolation of a membrane protein necessary for leukotriene production

1990 • 464 citations

Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.

1999 • 405 citations

Genetic Progression in the Pancreatic Ducts

2000 • 374 citations

Arachidonic Acid Stimulates Prostate Cancer Cell Growth: Critical Role of 5-Lipoxygenase

1997 • 262 citations

Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.

1996 • 252 citations

Islet Amyloid Polypeptide in Patients with Pancreatic Cancer and Diabetes

1994 • 234 citations

Cloning of the cDNA for human 5-lipoxygenase.

1988 • 222 citations

Characterization of the human 5-lipoxygenase gene.

1989 • 208 citations

Overexpression of cyclooxygenase-2 in carcinoma of the pancreas.

1999 • 188 citations

Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors

2001 • 184 citations

Lipoxygenase Inhibitors Abolish Proliferation of Human Pancreatic Cancer Cells

1999 • 160 citations

Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors.

1999 • 149 citations

Is profound peripheral insulin resistance in patients with pancreatic cancer caused by a tumor-associated factor?

1993 • 140 citations

Lipoxygenase Inhibition Induced Apoptosis, Morphological Changes, and Carbonic Anhydrase Expression in Human Pancreatic Cancer Cells

1999 • 134 citations

Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase.

1988 • 132 citations

Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.

2000 • 129 citations

Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets

2001 • 124 citations

Carcinogen-induced lesions in the rat pancreas: effects of varying levels of essential fatty acid.

1985 • 84 citations

Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors

1999 • 78 citations

Improving Results of Pancreaticoduodenectomy for Pancreatic Cancer

1999 • 75 citations

Pancreatic cancer cells selectively stimulate islet β cells to secrete amylin

1998 • 71 citations

The Intracellular Mechanism of Insulin Resistance in Pancreatic Cancer Patients¹

2000 • 68 citations

MOLECULAR GENETIC ALTERATIONS IN DUCTAL PANCREATIC ADENOCARCINOMAS

2000 • 65 citations

Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells.

1988 • 63 citations

Experimental evidence for the origin of ductal-type adenocarcinoma from the islets of Langerhans.

1997 • 55 citations

Modulation of insulin secretion by lipoxygenase products of arachidonic acid. Relation to lipoxygenase activity of pancreatic islets.

1983 • 54 citations

Stimulation of islet cell proliferation enhances pancreatic ductal carcinogenesis in the hamster model.

1996 • 52 citations

Effects on Glucose-induced Insulin Secretion of Lipoxygenase-derived Metabolites of Arachidonic Acid

1984 • 51 citations

Modulation of Pancreatic Carcinogenesis by Antioxidants

1999 • 49 citations

Characterization of the human 5-lipoxygenase gene.

1989 • 48 citations

Lipoxygenase Inhibition in Prostate Cancer

1999 • 47 citations

Diabetes and the risk of pancreatic cancer

1999 • 45 citations

The Intracellular Mechanism of Insulin Resistance in Pancreatic Cancer Patients

2000 • 45 citations

Influence of diabetes on susceptibility to experimental pancreatic cancer

1988 • 44 citations

Effects of dietary linoleic acid on pancreatic carcinogenesis in rats and hamsters.

1994 • 40 citations

Glucose Metabolic Alterations in Isolated and Perfused Rat Hepatocytes Induced by Pancreatic Cancer Conditioned Medium: A Low Molecular Weight Factor Possibly Involved

1999 • 40 citations

Characterization of a 5-lipoxygenase-activating protein binding assay: correlation of affinity for 5-lipoxygenase-activating protein with leukotriene synthesis inhibition.

1992 • 39 citations

Dietary fat, fatty acids and breast cancer

1997 • 37 citations

Pancreatic adenocarcinoma

1996 • 37 citations

Central Role of Arachidonate 5-Lipoxygenase in the Regulation of Cell Growth and Apoptosis in Human Prostate Cancer Cells

1999 • 36 citations

Reversal of enhanced pancreatic cancer growth in diabetes by insulin1

1995 • 34 citations

Leukotrienes stimulate insulin release from the rat pancreas.

1984 • 26 citations

Selective expression of an arachidonate 12-lipoxygenase by pancreatic islet beta-cells

1992 • 26 citations

Early changes in islet hormone secretion in the hamster pancreatic cancer model

2000 • 24 citations

The role of langerhans islets in pancreatic ductal adenocarcinoma

1997 • 21 citations

The Intracellular Mechanism of Insulin Resistance in the Hamster Pancreatic Ductal Adenocarcinoma Model

1998 • 19 citations

Lipoxygenase-generated icosanoids inhibit glucose-induced insulin release from rat islets

1990 • 17 citations

Unsaturated fatty acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth factor family proteins.

1994 • 13 citations

Arachidonate 5-lipoxygenase of porcine pancreas: its localization in acinar cells

1991 • 12 citations

Role of lipoxygenase pathways in the regulation of pancreatic cancer cell proliferation and survival

2001 • 12 citations

5-Lipoxygenase activity in the human pancreas.

1993 • 8 citations

Role of eicosanoids in biosynthesis and secretion of insulin.

1994 • 5 citations

Establishment of Human Pancreatic Ductal Cells in a Long-Term Culture

2000 • 3 citations

[54] Molecular biology and cloning of archidonate 5-lipoxygenase

1990 • 2 citations