Beta thalassemia: Mutations which affect processing of the β-globin mRNA precursor

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes.

1977 • 2,233 citations

Methylmercury as a reversible denaturing agent for agarose gel electrophoresis

1976 • 1,323 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Insertion of synthetic copies of human globin genes into bacterial plasmids

1978 • 350 citations

beta 0 thalassemia, a nonsense mutation in man.

1979 • 291 citations

Analysis of the β-δ-globin gene loci in normal and hb lepore DNA: Direct determination of gene linkage and intergene distance

1978 • 260 citations

A precursor of globin messenger RNA

1976 • 254 citations

The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.

1978 • 242 citations

Hematology of Infancy and Childhood

1981 • 206 citations

Recent developments in the molecular genetics of human hemoglobin

1979 • 199 citations

The structure and transcription of four linked rabbit β-like globin genes

1979 • 171 citations

Organization of human δ- and β-globin genes in cellular DNA and the presence of intragenic inserts

1978 • 141 citations

Use of recombinant plasmids to characterize collagen RNAs in normal and transformed chick embryo fibroblasts.

1979 • 123 citations

Active conformation of the globin genes in uninduced and induced mouse erythroleukemia cells

1978 • 110 citations

Decreased Globin Messenger RNA in Thalassemia Detected by Molecular Hybridization

1973 • 108 citations

[14] Isolation of specific RNAs using DNA covalently linked to diazobenzyloxymethyl cellulose or paper

1979 • 99 citations

The precursor of mouse β-globin messenger RNA contains two intervening RNA sequences

1978 • 89 citations

Processing of the mouse β-globin mRNA precursor: at least two cleavage-ligation reactions are necessary to excise the larger intervening sequence

1979 • 84 citations

A change in the stability of globin mRNA during the induction of murine erythroleukemia cells

1978 • 79 citations

Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia.

1975 • 77 citations

The structure of the human β-globin gene in β-thalassaemia

1979 • 73 citations

Presence of gene for β globin in homozygous β0 thalassaemia

1976 • 66 citations

Variability in the amount of β-globin mRNA in β0 thalassemia

1978 • 63 citations

Precursors of alpha and beta globin messenger RNAs

1978 • 62 citations

Synthesis of DNA complementary to separated human alpha and beta globin messenger RNAs.

1975 • 61 citations

Hemoglobin Messenger RNA from Human Bone Marrow ISOLATION AND TRANSLATION IN HOMOZYGOUS AND HETEROZYGOUS β-THALASSEMIA

1973 • 60 citations

Disorders of Human Hemoglobin

1980 • 59 citations

Characterization of β-globin mRNA in the β0 thalassemias

1978 • 46 citations

Molecular Genetics of Human Hemoglobin Synthesis

1979 • 46 citations

Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia.

1977 • 43 citations

Hemoglobin switching in sheep and goats. Preparation and characterization of complementary DNAs specific for the alpha-, beta-, and gamma-globin messenger RNAs of sheep.

1977 • 41 citations

Direct demonstration of β-globin mRNA in homozygous Ferrara β0-thalassaemia patients

1977 • 36 citations

Transcriptional and Post‐transcriptional Defects in β⁰‐Thalassaemia

1977 • 28 citations

Hemoglobin switching in sheep. Synthesis, cloning, and characterization of DNA sequences coding for the beta B, beta C, and gamma-globin mRNAs.

1979 • 27 citations

Hemoglobin switching in sheep: Commitment of erythroid stem cells to expression of the βC-globin gene and accumulation of βC-globin mRNA

1978 • 15 citations