[LEU5]enkephalin containing peptides derived from a common precursor: Evaluation of opioid activity in in vitro bioassays

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

Dynorphin-(1-13), an extraordinarily potent opioid peptide.

1979 • 852 citations

Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor

1982 • 777 citations

Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

1982 • 448 citations

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

1981 • 390 citations

The Rate of Action of Drugs on Cells

1937 • 319 citations

The Mode of Action of Drugs on Cells.

1933 • 258 citations

Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions

1982 • 235 citations

α-Neo-endorphin: A “big” leu-enkephalin with potent opiate activity from porcine hypothalami

1979 • 229 citations

Rabbit vas deferens: A specific bioassay for opioid κ-receptor agonists

1981 • 180 citations

Multiple endogenous opioid peptides

1983 • 177 citations

The complete amino acid sequence of α-neo-endorphin

1981 • 153 citations

Isolation and structure of dynorphin, an opioid peptide, from porcine duodenum

1982 • 144 citations

Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary.

1982 • 137 citations

Evidence that dynorphin-(1–13) acts as an agonist on opioid κ-receptors

1982 • 131 citations

Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens

1980 • 129 citations

Immunohistochemical distribution of dynorphin B in rat brain: relation to dynorphin A and alpha-neo-endorphin systems.

1983 • 124 citations

The preference of putative pro-enkephalins for different types of opiate receptors

1981 • 114 citations

Dynorphin interaction at the κ-opiate site

1981 • 111 citations

Endogenous opioid peptides: A guide to structures and terminology

1982 • 109 citations

A new opioid octapeptide related to dynorphin from porcine hypothalamus

1980 • 104 citations

β-Neo-endorphin, a new hypothalamic “big” Leu-enkephalin of porcine origin: Its purification and the complete amino acid sequence

1981 • 100 citations

Pro-dynorphin peptides are found in the same neurons throughout rat brain: immunocytochemical study.

1983 • 88 citations

Rimorphin, a unique, naturally occurring [Leu]enkephalin-containing peptide found in association with dynorphin and alpha-neo-endorphin.

1982 • 83 citations

Opioid peptides have found their roots

1982 • 75 citations

A Rapid Assay of Affinity for the Narcotic Receptor in Rat Brain: Application to Methadone Analogues

1974 • 66 citations

Evidence for the occurrence of the opioid octapeptide dynorphin-(1–8) in the neurointermediate pituitary of rats

1981 • 62 citations

Highly specific opiate receptors for dynorphin-(1–13) in the mouse vas deferens

1980 • 60 citations

The choice of opiate receptor subtype by neo-endorphins

1982 • 52 citations

Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin.

1982 • 45 citations

Dynorphin(1–13), a long-lasting inhibitor of opiate receptor binding

1982 • 38 citations

Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.

1983 • 34 citations

Characterization of rimorphin, a new [Leu] enkephalin-containing peptide from bovine posterior pituitary glands

1982 • 33 citations

Multiple forms of immunoreactive dynorphin in rat pituitary and brain

1982 • 19 citations