Role of excitatory amino acid transporter 1 in neonatal rat neuronal damage induced by hypoxia-ischemia

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

1981 • 2,073 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

1995 • 1,124 citations

Glutamate release in severe brain ischaemia is mainly by reversed uptake

2000 • 1,105 citations

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

1997 • 909 citations

Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms

1994 • 630 citations

A Stereotaxic Atlas of the Developing Rat Brain

1970 • 589 citations

Glutamate Transporter Protein Subtypes Are Expressed Differentially during Rat CNS Development

1997 • 553 citations

The role of glutamate in epilepsy and other CNS disorders.

1994 • 476 citations

Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro

1985 • 464 citations

Glutamate Transporter Alterations in Alzheimer Disease Are Possibly Associated with Abnormal APP Expression

1997 • 325 citations

Early Detection of DNA Strand Breaks in the Brain After Transient Focal Ischemia: Implications for the Role of DNA Damage in Apoptosis and Neuronal Cell Death

1997 • 312 citations

Hypoxia—ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum

1997 • 271 citations

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

1996 • 237 citations

Posthypoxic cooling of neonatal rats provides protection against brain injury.

1996 • 230 citations

A new family of neurotransmitter transporters: the high‐affinity glutamate transporters

1993 • 228 citations

Changes of NMDA Receptor Subunit (NR1, NR2B) and Glutamate Transporter (GLT1) mRNA Expression in Huntingtonʼs Disease—An In Situ Hybridization Study

1997 • 227 citations

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

1995 • 174 citations

Neuropathology of remote hypoxic-ischemic damage in the immature rat

1991 • 168 citations

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death

1998 • 163 citations

MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain

1989 • 161 citations

Perinatal Hypoxia‐Ischemia Disrupts Striatal High‐Affinity [³H]Glutamate Uptake into Synaptosomes

1986 • 160 citations

Adenosine triphosphate depletion reverses sodium-dependent, neuronal uptake of glutamate in rat hippocampal slices

1993 • 157 citations

Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus

1995 • 145 citations

Alterations in Glutamate Transporter Protein Levels in Kindling‐Induced Epilepsy

1997 • 137 citations

Glutamate and other CSF amino acids in Alzheimer's disease

1992 • 121 citations

Excitatory amino acid release from astrocytes during energy failure by reversal of sodium‐dependent uptake

1995 • 115 citations

Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia

1996 • 111 citations

Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity

1999 • 95 citations

MOLECULAR PHARMACOLOGY AND PHYSIOLOGY OF GLUTAMATE TRANSPORTERS IN THE CENTRAL NERVOUS SYSTEM

1998 • 88 citations

Marked increase in glutamate-aspartate transporter (GLAST/GluT-1) mRNA following transient retinal ischemia

1994 • 82 citations

Glutamate efflux via the reversal of the sodium-dependent glutamate transporter caused by glycolytic inhibition in rat cultured astrocytes

1994 • 80 citations

In Situ Detection of Neuronal DNA Strand Breaks Using the Klenow Fragment of DNA Polymerase I Reveals Different Mechanisims of Neuron Death After Global Cerebral Ischemia

1999 • 79 citations

What excitotoxin kills striatal neurons in Huntington's disease? Clues from neurochemical studies

1990 • 76 citations

Glutamate uptake and glutamate content in primary cultures of mouse astrocytes during anoxia, substrate deprivation and simulated ischemia under normothermic and hypothermic conditions

1993 • 64 citations

Stimulation of glutamate uptake and Na, K-ATPase activity in rat astrocytes exposed to ischemia-like insults

1997 • 49 citations

bcl-2 Prolongs neuronal survival during hypoxia-induced apoptosis

1999 • 49 citations

Mechanisms of synaptic pathology in Alzheimer’s disease

1998 • 45 citations

Increased transcription of glutamate–aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure

1998 • 42 citations

Net Glutamate Release from Astrocytes Is Not Induced by Extracellular Potassium Concentrations Attainable in Brain

1997 • 36 citations

Effects of Ischaemic Conditions on Uptake of Glutamate, Aspartate, and Noradrenaline by Cell Lines Derived from the Human Nervous System

1994 • 25 citations

Differential Effects of Anoxia and Glutamate on Cultured Neocortical Neurons

1998 • 21 citations

Ischemia-induced upregulation of excitatory amino acid transport sites

1993 • 20 citations

Effect of glutamate transporter on neuronal damage induced by photochemical thrombotic brain ischemia

1998 • 20 citations

Reverse transport of glutamate during depolarization in immature hippocampal slices

1999 • 16 citations

Altered expression of glutamate transporter GLAST mRNA in rat brain after photochemically induced focal ischemia

1998 • 10 citations

[35] Use of antisense oligodeoxynucleotides to inhibit expression of glutamate transporter subtypes

1998 • 9 citations

Hypoxia-ischemia altered expression of glutamate transporter EAAT1 in neonatal rat brain.

1999 • 2 citations