Cell Compartmentalization of Cholesterol Biosynthesis^a

Regulation of the mevalonate pathway

1990 • 5,282 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Identification of a nuclear receptor that is activated by farnesol metabolites

1995 • 1,134 citations

A conserved tripeptide sorts proteins to peroxisomes.

1989 • 1,113 citations

Protein Import into Peroxisomes and Biogenesis of the Organelle

1993 • 411 citations

Biosynthesis of isoprenoid compounds

1982 • 362 citations

Purification and properties of sterol carrier protein2.

1980 • 237 citations

Morphological analysis of protein transport from the ER to Golgi membranes in digitonin-permeabilized cells: role of the P58 containing compartment.

1992 • 207 citations

How proteins penetrate peroxisomes

1995 • 198 citations

Subcellular localization of sterol carrier protein-2 in rat hepatocytes: its primary localization to peroxisomes.

1989 • 191 citations

Infantile phytanic acid storage disease, a possible variant of Refsum's disease: Three cases, including ultrastructural studies of the liver

1982 • 177 citations

Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.

1994 • 175 citations

Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1994 • 174 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells.

1985 • 158 citations

The targeting and assembly of peroxisomal proteins: some old rules do not apply

1996 • 157 citations

The participation of sterol carrier protein2 in the conversion of cholesterol to cholesterol ester by rat liver microsomes.

1981 • 154 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analyses.

1986 • 147 citations

Antibodies directed against the peroxisomal targeting signal of firefly luciferase recognize multiple mammalian peroxisomal proteins.

1990 • 133 citations

Infantile Refsum disease: an inherited peroxisomal disorder

1987 • 131 citations

Cholesterol synthesis in rat liver peroxisomes. Conversion of mevalonic acid to cholesterol.

1987 • 117 citations

Farnesyl-diphosphate synthase is localized in peroxisomes.

1994 • 107 citations

Cloning, expression, and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs.

1991 • 102 citations

Compartmentalization of Cholesterol Biosynthesis

1996 • 94 citations

Rat liver peroxisomes catalyze the initial step in cholesterol synthesis. The condensation of acetyl-CoA units into acetoacetyl-CoA.

1990 • 93 citations

Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase.

1992 • 88 citations

Mevalonate kinase is predominantly localized in peroxisomes and is defective in patients with peroxisome deficiency disorders.

1994 • 88 citations

The Role of Peroxisomes in Cholesterol Metabolism

1992 • 71 citations

Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes

1990 • 63 citations

Subcellular localization of squalene synthase in rat hepatic cells. Biochemical and immunochemical evidence

1993 • 62 citations

Molecular Cloning and Expression of the cDNAs Encoding Human and Yeast Mevalonate Pyrophosphate Decarboxylase

1996 • 61 citations

Mevalonate kinase is localized in rat liver peroxisomes.

1992 • 59 citations

Nonspecific lipid transfer protein (Sterol carrier protein-2) defective in patients with deficient peroxisomes.

1990 • 58 citations

Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthetase.

1992 • 58 citations

Metabolism of acetyl-CoA by isolated peroxisomal fractions: formation of acetate and acetoacetyl-CoA.

1991 • 55 citations

Hydroxyeicosatetraenoic acid metabolism in cultured human skin fibroblasts. Evidence for peroxisomal beta-oxidation.

1990 • 54 citations

Plasma and skin fibroblast C ₂₆ fatty acids in infantile Refsum's disease

1984 • 54 citations

Normal cholesterol synthesis in human cells requires functional peroxisomes

1991 • 44 citations

Molecular Cloning of Human Phosphomevalonate Kinase and Identification of a Consensus Peroxisomal Targeting Sequence

1996 • 41 citations

Purification and regulation of mevalonate kinase from rat liver.

1990 • 41 citations

3-Methylglutaconic Acidemia in Smith-Lemli-Opitz Syndrome

1995 • 40 citations

Chicken Sterol Carrier Protein m2/Sterol Carrier Protein x: cDNA Cloning Reveals Evolutionary Conservation of Structure and Regulated Expression

1993 • 37 citations

The role of sterol carrier protein2 and other hepatic lipid-binding proteins in bile-acid biosynthesis

1986 • 36 citations

cDNAs Encoding Members of a Family of Proteins Related to Human Sterol Carrier Protein 2 and Assignment of the Gene to Human Chromosome 1 p21→pter

1991 • 34 citations

A Human Promyelocyte mRNA Transiently Induced by TPA Is Homologous to Yeast IPP Isomerase

1994 • 31 citations

Permeability properties of peroxisomes in digitonin‐permeabilized rat hepatocytes

1993 • 30 citations

Human liver alcohol dehydrogenases catalyze the oxidation of the intermediary alcohols of the shunt pathway of mevalonate metabolism

1991 • 30 citations

Reduced cellular cholesterol content in peroxisome-deficient fibroblasts is associated with impaired uptake of the patient's low density lipoprotein and with reduced cholesterol synthesis.

1995 • 24 citations

Synergistic Activation of Transcription by the Mutant and Wild-type Minimal Transcriptional Activation Domain of VP16

1996 • 24 citations

A sibship with a mild variant of Zellweger syndrome

1986 • 21 citations

Diurnal variation of HMG-CoA reductase activity in rat liver peroxisomes

1987 • 19 citations

Subcellular localization of squalene synthase in human hepatoma cell line Hep G2

1992 • 13 citations

Peroxisomal cholesterol synthesis in vivo: Accumulation of 4-methyl intermediate sterols after aminotriazole inhibition of cholesterol synthesis

1994 • 11 citations