The Role of the Cytochrome P450-Dependent Metabolites of Arachidonic Acid in Blood Pressure Regulation and Renal Function A Review

Renal cytochrome P450-related arachidonate metabolite inhibits (Na+ + K+)ATPase

1985 • 314 citations

Cytochrome P-450 Metabolism of Arachidonic Acid

1991 • 290 citations

Treatment with Tin Prevents the Development of Hypertension in Spontaneously Hypertensive Rats

1989 • 282 citations

Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels

1994 • 217 citations

Effect of Cytochrome P450 Arachidonate Metabolites on Ion Transport in Rabbit Kidney Loop of Henle

1991 • 216 citations

Cytochrome P450 mono‐oxygenase‐regulated signalling of Ca2+ entry in human and bovine endothelial cells.

1995 • 214 citations

Activation of K+ channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid

1993 • 196 citations

Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism

1988 • 194 citations

Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.

1994 • 190 citations

Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.

1987 • 176 citations

Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats.

1990 • 170 citations

Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats.

1994 • 169 citations

Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.

1990 • 169 citations

12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea.

1987 • 166 citations

Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase

1989 • 164 citations

Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow

1994 • 158 citations

Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.

1992 • 151 citations

Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.

1990 • 143 citations

NOVEL HYPOTHALAMIC ARACHIDONATE PRODUCTS STIMULATE SOMATOSTATIN RELEASE FROM THE MEDIAN EMINENCE¹

1983 • 141 citations

Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats

1988 • 140 citations

Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid

1993 • 134 citations

Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase.

1989 • 129 citations

Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback

1994 • 125 citations

Vasoactivity of arachidonic acid epoxides

1987 • 125 citations

Endogenous non-cyclooxygenase metabolites of arachidonic acid modulate growth and mRNA levels of immediate-early response genes in rat mesangial cells

1991 • 122 citations

An epoxygenase metabolite of arachidonic acid mediates angiotensin II-induced rises in cytosolic calcium in rabbit proximal tubule epithelial cells.

1991 • 122 citations

Contribution of NO and cytochrome P450 to the vasodilator effect of bradykinin in the rat kidney

1992 • 121 citations

Intracellular signaling in the regulation of renal Na-K-ATPase. II. Role of eicosanoids.

1993 • 118 citations

Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway.

1987 • 115 citations

The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.

1995 • 113 citations

Structural identification of cytochrome P450-dependent arachidonate metabolites formed by rabbit medullary thick ascending limb cells

1991 • 111 citations

Renal vasodilator activity of 5,6-epoxyeicosatrienoic acid depends upon conversion by cyclooxygenase and release of prostaglandins

1993 • 109 citations

Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450.

1993 • 105 citations

Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver.

1994 • 103 citations

Age-related changes in renal cytochrome P-450 arachidonic acid metabolism in spontaneously hypertensive rats

1992 • 102 citations

Epoxyeicosatrienoic acids activate Na⁺/H⁺ exchange and are mitogenic in cultured rat glomerular mesangial cells

1990 • 97 citations

Cytochrome P450-dependent arachidonic acid metabolism in human kidney

1990 • 92 citations

Altered pressure-natriuresis relationship in young spontaneously hypertensive rats.

1987 • 86 citations

Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta

1991 • 85 citations

19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase

1988 • 84 citations

Parathyroid hormone inhibits Na(+)-K(+)-ATPase through a cytochrome P-450 pathway

1994 • 83 citations

Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses

1990 • 83 citations

Cytochrome P450, drug metabolizing enzymes and arachidonic acid metabolism in bovine ocular tissues

1987 • 80 citations

Renal cytochrome P-450-dependent metabolism of arachidonic acid in spontaneously hypertensive rats

1988 • 79 citations

Brain Synthesis and Cerebrovascular Action of Epoxygenase Metabolites of Arachidonic Acid

1992 • 78 citations

Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid.

1986 • 77 citations

Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure

1994 • 76 citations

A search for an ‘Ouabain-like’ substance from the electric organ of Electrophorus electricus which led to arachidonic acid and related fatty acids

1984 • 76 citations

Arachidonic acid metabolism in a cell suspension isolated from rabbit renal outer medulla.

1984 • 75 citations

Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney

1991 • 71 citations

A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells.

1989 • 69 citations

Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct.

1989 • 66 citations

Arachidonic acid metabolism in isolated pancreatic islets

1984 • 65 citations

Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes

1993 • 61 citations

Renal Arachidonic Acid Metabolism

1984 • 60 citations

Biological activity and metabolism of 20‐hydroxyeicosatetraenoic acid in the human platelet

1992 • 57 citations

Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.

1987 • 57 citations

Tin-Mediated Heme Oxygenase Gene Activation and Cytochrome P450 Arachidonate Hydroxylase Inhibition in Spontaneously Hypertensive Rats

1994 • 57 citations

Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine

1987 • 57 citations

Role of Cytochrome P-450 in Elevating Renal Vascular Tone in Spontaneously Hypertensive Rats

1993 • 55 citations

Renal arachidonic acid metabolism. The third pathway.

1985 • 53 citations

Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.

1994 • 49 citations

Enhanced vascular tone in the renal vasculature of spontaneously hypertensive rats.

1990 • 48 citations

Modulation of erythropoiesis by novel human bone marrow cytochrome P450- dependent metabolites of arachidonic acid

1991 • 46 citations

A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs)

1987 • 43 citations

Arachidonic acid metabolism in isolated pancreatic islets

1985 • 42 citations

Renal Microsomal Cytochrome P-450 and the Oxidative Metabolism of Arachidonic Acid**A preliminary report of parts of this work was presented at the 18th Annual Meeting of the American Society of Nephrology in New Orleans, Louisiana, December 1985.

1988 • 41 citations

Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin.

1992 • 40 citations

Oxidation and keto reduction of 12-hydroxy-5,8,10,14-eicosatetraenoic acids in bovine corneal epithelial microsomes

1994 • 33 citations

Modulation of Corneal Heme Oxygenase Expression by Oxidative Stress Agents

1995 • 31 citations

Metabolism of arachidonic acid to epoxyeicosatrienoic acids by human granulosa cells may mediate steroidogenesis.

1993 • 31 citations

Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporin A

1994 • 30 citations

The renal cytochrome P-450 arachidonic acid system

1992 • 28 citations

Role of the Kidney in the Pathogenesis of Primary Hypertension

1990 • 27 citations

Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine

1993 • 27 citations

Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder

1987 • 26 citations

Partial purification and characterization of a peroxidase activity from human placenta

1990 • 26 citations

P-450-dependent arachidonic acid metabolism in rabbit olfactory microsomes.

1992 • 25 citations

General anesthetics inhibit cytochrome P450 monooxygenases and arachidonic acid metabolism

1993 • 24 citations

Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid.

1991 • 20 citations

Contribution of K+ channels to arachidonic acid-induced endothelium-dependent vasodilation in rat isolated perfused mesenteric arteries.

1991 • 20 citations

Cytochrome P-450-dependent vasodilation of rat kidney by arachidonic acid

1991 • 18 citations

Gluco- and mineralocorticoids control adenylate cyclase in specific nephron segments

1990 • 18 citations

Formation of cis-14,15-oxido-5,8,11-icosatrienoic acid from phosphatidylinositol in human platelets.

1987 • 17 citations

Effects of epoxyeicosatrienoic acids on ⁸⁶Rb uptake in renal epithelial cells

1994 • 17 citations

Renal cytochrome P-450-related arachidonate metabolism in rabbit aortic coarctation

1988 • 14 citations

Cardiovascular and renal actions of cytochrome P-450 metabolites of arachidonic acid.

1989 • 14 citations

Cytochrome P450 Dependent Arachidonic Acid Metabolism in Hemopoietic Cells

1989 • 12 citations

Reciprocal effects of dexamethasone on vasodilatory responses to arachidonic acid and prostanoids in the isolated perfused rabbit kidney.

1990 • 12 citations

Cytochrome P450-dependent arachidonate metabolites, renal function and blood pressure regulation.

1991 • 12 citations

Role of eicosanoids in vasopressin-induced calcium mobilization in A7r5 vascular smooth muscle cells

1993 • 12 citations

Functional effects of cytochrome P450 arachidonate metabolites in the kidney.

1991 • 11 citations

Prolactin secretion in anterior pituitary cells: effect of eicosanoids.

1992 • 10 citations

Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy

1993 • 8 citations

Modification of arachidonic acid metabolism via the cytochrome P450-related monooxygenase system.

1990 • 8 citations

Increased renal production of cytochrome P450-dependent metabolites of arachidonic acid in cyclosporine-induced nephrotoxicity.

1991 • 7 citations

Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE

1992 • 6 citations

Cytochrome P-450 metabolites of arachidonic acid: implications for blood pressure regulation.

1990 • 4 citations

Deleted Work

1955 • 0 citations