Introduction

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults

1993 • 10,139 citations

Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension

2000 • 4,895 citations

Survival in Patients with Primary Pulmonary Hypertension

1991 • 3,369 citations

Sleep-disordered Breathing and Cardiovascular Disease

2001 • 2,865 citations

Bosentan Therapy for Pulmonary Arterial Hypertension

2002 • 2,715 citations

Heart-Lung Transplantation

2016 • 2,165 citations

The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure.

1985 • 2,042 citations

Primary Pulmonary Hypertension

1987 • 2,027 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

Inhaled Iloprost for Severe Pulmonary Hypertension

2002 • 1,760 citations

The Effect of High Doses of Calcium-Channel Blockers on Survival in Primary Pulmonary Hypertension

1992 • 1,541 citations

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study

2001 • 1,521 citations

Long-term intravenous epoprostenol infusion in primary pulmonary hypertension

2002 • 1,383 citations

Continuous Subcutaneous Infusion of Treprostinil, a Prostacyclin Analogue, in Patients with Pulmonary Arterial Hypertension

2002 • 1,382 citations

Obstructive Sleep Apnea

1996 • 1,295 citations

Survival in Primary Pulmonary Hypertension

2002 • 1,192 citations

Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension

1996 • 1,131 citations

Clinical Correlates and Prognostic Significance of Six-minute Walk Test in Patients with Primary Pulmonary Hypertension

2000 • 1,129 citations

Primary pulmonary hypertension: natural history and the importance of thrombosis.

1984 • 1,077 citations

Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension

1991 • 1,062 citations

Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease

2000 • 1,051 citations

Doppler echocardiographic index for assessment of global right ventricular function

1996 • 966 citations

Pulmonary Hypertension

2006 • 917 citations

Plasma Brain Natriuretic Peptide as a Prognostic Indicator in Patients With Primary Pulmonary Hypertension

2000 • 881 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Comparison of therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised prospective parallel trial

1999 • 819 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

1998 • 799 citations

Prostacyclin Synthase Expression Is Decreased in Lungs from Patients with Severe Pulmonary Hypertension

1999 • 788 citations

Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension

2002 • 788 citations

Increased Adhesion Molecules Expression and Production of Reactive Oxygen Species in Leukocytes of Sleep Apnea Patients

2002 • 735 citations

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 731 citations

NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease

1997 • 719 citations

Reduction in Pulmonary Vascular Resistance with Long-Term Epoprostenol (Prostacyclin) Therapy in Primary Pulmonary Hypertension

1998 • 674 citations

Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial

2002 • 639 citations

Outcome of Pulmonary Vascular Disease in Pregnancy: A Systematic Overview From 1978 Through 1996

1998 • 638 citations

Beraprost therapy for pulmonary arterial hypertension

2003 • 627 citations

Nitric oxide and its role in the cardiovascular system

1995 • 598 citations

Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension

2002 • 589 citations

Long-Term Treatment of Primary Pulmonary Hypertension with Aerosolized Iloprost, a Prostacyclin Analogue

2000 • 583 citations

Primary Pulmonary Hypertension

1970 • 565 citations

Assessment of Survival in Patients With Primary Pulmonary Hypertension

2002 • 562 citations

Value of a Doppler-Derived Index Combining Systolic and Diastolic Time Intervals in Predicting Outcome in Primary Pulmonary Hypertension

1998 • 560 citations

Survival in Primary Pulmonary Hypertension with Long-Term Continuous Intravenous Prostacyclin

1994 • 558 citations

Primary pulmonary hypertension

1998 • 539 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Long-Term Prostacyclin for Pulmonary Hypertension With Associated Congenital Heart Defects

1999 • 510 citations

Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension

2002 • 507 citations

Balloon Pulmonary Angioplasty for Treatment of Chronic Thromboembolic Pulmonary Hypertension

2001 • 487 citations

Sildenafil Inhibits Hypoxia-Induced Pulmonary Hypertension

2001 • 485 citations

Circulating Nitric Oxide Is Suppressed in Obstructive Sleep Apnea and Is Reversed by Nasal Continuous Positive Airway Pressure

2000 • 469 citations

A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric-oxide Synthase May Explain the “Arginine Paradox”

1997 • 450 citations

Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth

1990 • 447 citations

Comparison of the hemodynamics and survival of adults with severe primary pulmonary hypertension or Eisenmenger syndrome.

1996 • 435 citations

Littérature commentée

1996 • 431 citations

Hemodynamics and Survival in Patients With Pulmonary Arterial Hypertension Related to Systemic Sclerosis*

2003 • 431 citations

Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1995 • 430 citations

Vasodilator Therapy for Primary Pulmonary Hypertension in Children

1999 • 425 citations

Effect of Inhaled Iloprost Plus Oral Sildenafil in Patients With Primary Pulmonary Hypertension

2001 • 402 citations

Big Endothelin-1 and Endothelin-1 Plasma Levels Are Correlated With the Severity of Primary Pulmonary Hypertension

2001 • 394 citations

Primary pulmonary hypertension

1951 • 385 citations

Pulmonary hypertension in the crest syndrome variant of systemic sclerosis

1986 • 377 citations

Survival in primary pulmonary hypertension. Validation of a prognostic equation.

1994 • 368 citations

Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension

2003 • 352 citations

Sildenafil Ameliorates Effects of Inhaled Nitric Oxide Withdrawal

1999 • 344 citations

Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta.

1991 • 340 citations

PULMONARY HYPERTENSION WITH SPECIAL REFERENCE TO THE VASOCONSTRICTIVE FACTOR

1958 • 337 citations

Long-Term Outcome after Pulmonary Thromboendarterectomy

1999 • 321 citations

Prognostic Factors for Survival in Human Immunodeficiency Virus–associated Pulmonary Arterial Hypertension

2003 • 318 citations

Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levels

1995 • 315 citations

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia

1999 • 312 citations

A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension

2000 • 309 citations

Primary Pulmonary Hypertension

1993 • 307 citations

Primary Pulmonary Hypertension: Improved Long-Term Effects and Survival With Continuous Intravenous Epoprostenol Infusion

1997 • 307 citations

HIV-associated primary pulmonary hypertension. A case control study. Swiss HIV Cohort Study.

1997 • 303 citations

Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats

1995 • 298 citations

Platelet-derived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients

1998 • 297 citations

Sildenafil for Long-Term Treatment of Nonoperable Chronic Thromboembolic Pulmonary Hypertension

2003 • 294 citations

Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension

1998 • 286 citations

Serum Uric Acid Levels Correlate with the Severity and the Mortality of Primary Pulmonary Hypertension

1999 • 285 citations

Oxygen desaturation on the six-minute walk test and mortality in untreated primary pulmonary hypertension

2001 • 282 citations

Inhaled Iloprost To Treat Severe Pulmonary Hypertension: An Uncontrolled Trial

2000 • 281 citations

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

1990 • 278 citations

Primary pulmonary hypertension

1970 • 277 citations

Daytime Pulmonary Hypertension in Patients with Obstructive Sleep Apnea Syndrome

1988 • 268 citations

Coronary atherosclerotic wall thickening and vascular reactivity in humans. Elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis.

1994 • 264 citations

Continuous Positive Airway Pressure Treatment Improves Pulmonary Hemodynamics in Patients with Obstructive Sleep Apnea

2002 • 260 citations

Outcome in 91 Consecutive Patients with Pulmonary Arterial Hypertension Receiving Epoprostenol

2003 • 259 citations

Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension.

1989 • 250 citations

Clinical Efficacy of Sitaxsentan, an Endothelin-A Receptor Antagonist, in Patients With Pulmonary Arterial Hypertension

2002 • 243 citations

The Effect of Anticoagulant Therapy in Primary and Anorectic Drug-Induced Pulmonary Hypertension

1997 • 242 citations

Pulmonary hypertension in patients with human immunodeficiency virus infection. Comparison with primary pulmonary hypertension.

1994 • 239 citations

Efficacy and Safety of Treprostinil: An Epoprostenol Analog for Primary Pulmonary Hypertension

2003 • 230 citations

Arginine Needs, Physiological State and Usual Diets. A Reevaluation

1986 • 230 citations

Endothelial Dysfunction in Coronary Artery Disease

1993 • 227 citations

Pulmonary arterial hypertension in patients with sleep apnoea syndrome

2000 • 225 citations

Prolonged Administration of <scp>l</scp> -Arginine Ameliorates Chronic Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats

1997 • 223 citations

Prostacyclin Therapy Before Pulmonary Thromboendarterectomy in Patients With Chronic Thromboembolic Pulmonary Hypertension*

2003 • 215 citations

Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension

1999 • 208 citations

Single Lung Transplantation for Pulmonary Hypertension

1995 • 208 citations

Short-term Oral Administration of <scp>l-</scp>Arginine Improves Hemodynamics and Exercise Capacity in Patients with Precapillary Pulmonary Hypertension

2001 • 204 citations

The effects of chronic prostacyclin therapy on cardiac output and symptoms in primary pulmonary hypertension

1999 • 199 citations

Primary Pulmonary Hypertension in Association with Human Immunodeficiency Virus Infection: A Possible Viral Etiology for Some Forms of Hypertensive Pulmonary Arteriopathy

1992 • 195 citations

Pulsed Delivery of Inhaled Nitric Oxide to Patients With Primary Pulmonary Hypertension

1996 • 188 citations

Atherosclerosis: Risk factors and the vascular endothelium

1996 • 188 citations

Cellular and molecular mechanisms in the pathogenesis of severe pulmonary hypertension

1995 • 185 citations

Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability.

1995 • 182 citations

Results of single and bilateral lung transplantation in 131 consecutive recipients. Washington University Lung Transplant Group.

1994 • 182 citations

Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation

1975 • 181 citations

Short-term Pulmonary Vasodilation With<scp>l</scp>-Arginine in Pulmonary Hypertension

1995 • 178 citations

Aging-Associated Endothelial Dysfunction in Humans Is Reversed by L-Arginine

1996 • 176 citations

Epoprostenol (Prostacyclin) Therapy in HIV-associated Pulmonary Hypertension

2000 • 175 citations

Thromboendarterectomy for Chronic, Major-Vessel Thromboembolic Pulmonary Hypertension

1987 • 175 citations

Pulmonary Hypertension in Patients With Obstructive Sleep Apnea Syndrome

1997 • 173 citations

Perfusion Scan Findings Understate the Severity of Angiographic and Hemodynamic Compromise in Chronic Thromboembolic Pulmonary Hypertension

1988 • 172 citations

Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension

2002 • 171 citations

Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.

1996 • 170 citations

DEVELOPMENT OF BRONCHIOLITIS OBLITERANS SYNDROME IN RECIPIENTS OF HEART-LUNG TRANSPLANTATION-EARLY RISK FACTORS

1996 • 161 citations

Amelioration by L-Arginine of a Dysfunctional Arginine/Nitric Oxide Pathway in Diabetic Endothelium

1995 • 161 citations

Frequency and prognostic significance of pericardial effusion in primary pulmonary hypertension

1999 • 159 citations

Daytime Pulmonary Hemodynamics in Patients with Obstructive Sleep Apnea without Lung Disease

1999 • 156 citations

The Prognostic Role of the ECG in Primary Pulmonary Hypertension

2002 • 154 citations

Pulmonary hypertension in obstructive sleep apnoea

1995 • 153 citations

Primary pulmonary hypertension

1988 • 153 citations

Predictors of mortality in pulmonary thromboendarterectomy

1996 • 153 citations

New Treatments for Pulmonary Arterial Hypertension

2002 • 153 citations

Indications for and results of single, bilateral, and heart-lung transplantation for pulmonary hypertension

1994 • 151 citations

Potent stimulation of monocytic endothelin-1 production by HIV-1 glycoprotein 120.

1993 • 150 citations

Oral Beraprost Sodium, a Prostaglandin I ₂ Analogue, for Intermittent Claudication

2000 • 149 citations

Pulmonary hypertension and pregnancy: a series of eight cases

1994 • 149 citations

The Biological and Pharmacological Role of Nitric Oxide in Platelet Function

1993 • 148 citations

Chronic thromboembolism: diagnosis with helical CT and MR imaging with angiographic and surgical correlation.

1997 • 147 citations

Mid-term results of pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension

1996 • 144 citations

Endothelium-Dependent Responses in Hypertension.

1995 • 144 citations

Primary pulmonary hypertension in children: Clinical characterization and survival

1995 • 141 citations

Primary Pulmonary Hypertension

1987 • 137 citations

Modifications of techniques and early results of pulmonary thromboendarterectomy for chronic pulmonary embolism

1987 • 136 citations

Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension

2000 • 136 citations

Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease

1998 • 135 citations

Long-term Treatment With Oral Sildenafil in Addition to Continuous IV Epoprostenol in Patients With Pulmonary Arterial Hypertension

2003 • 134 citations

Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity

1998 • 133 citations

Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging

1994 • 131 citations

STRUCTURAL AND PATHOLOGIC CHANGES IN THE LUNG VASCULATURE IN CHRONIC LIVER DISEASE

1996 • 129 citations

Portal axis thrombosis with spontaneous portacaval shunt and resultant cor pulmonale.

1951 • 129 citations

Pregnancy and Primary Pulmonary Hypertension

2001 • 124 citations

Discovery of TBC11251, a Potent, Long Acting, Orally Active Endothelin Receptor-A Selective Antagonist

1997 • 124 citations

Pharmacokinetics and pharmacodynamics of the prostacyclin analogue iloprost in man

1986 • 123 citations

Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus

1997 • 119 citations

Lung transplantation for pulmonary vascular disease

2002 • 117 citations

Ultrasonicversusjet nebulization of iloprost in severe pulmonary hypertension

2001 • 117 citations

Clinical Significance of the Pulmonary Vasodilator Response During Short-term Infusion of Prostacyclin in Primary Pulmonary Hypertension

1996 • 117 citations

PRIMARY PULMONARY HYPERTENSION IN PREGNANCY

1964 • 116 citations

Obstructive Apnea during Sleep Is Associated with Peripheral Vasoconstriction

2002 • 116 citations

Release of nucleosides from canine and human hearts as an index of prior ischemia

1979 • 104 citations

Sleep apnea and pulmonary hypertension

1986 • 102 citations

Primary pulmonary hypertension in pregnancy; a role for novel vasodilators

2001 • 101 citations

Endothelial function in congestive heart failure

1993 • 100 citations

Nocturnal Hypoxemia Is Common in Primary Pulmonary Hypertension

2001 • 100 citations

Single- Versus Double-Lung Transplantation For Pulmonary Hypertension

1998 • 99 citations

Pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension: hemodynamic characteristics and changes✩

2000 • 99 citations

Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats

1997 • 98 citations

The new clinical trials on pharmacological treatment in pulmonary arterial hypertension

2002 • 97 citations

Effects of Dipyridamole and Inhaled Nitric Oxide in Pediatric Patients with Pulmonary Hypertension

1998 • 97 citations

Echocardiographic characterization of the improvement in right ventricular function in patients with severe pulmonary hypertension after single-lung transplantation

1993 • 95 citations

Short-term hemodynamic effect of a new oral PGI2 analogue, Beraprost, in primary and secondary pulmonary hypertension

1996 • 92 citations

Developmental Changes in Lung cGMP Phosphodiesterase-5 Activity, Protein, and Message

1998 • 91 citations

The Use of Cylexin (CY-1503) in Prevention of Reperfusion Lung Injury in Patients Undergoing Pulmonary Thromboendarterectomy

2000 • 91 citations

Comparative outcome of heart-lung and lung transplantation for pulmonary hypertension

1993 • 91 citations

Arginine Deficiency Accompanies Persistent Pulmonary Hypertension of the Newborn

1994 • 90 citations

Sildenafil Modulates Hemodynamics and Pulmonary Gas Exchange

2001 • 89 citations

M&amp;B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs

1993 • 88 citations

Lung transplantation for primary and secondary pulmonary hypertension

2001 • 87 citations

Effect of Orally Active Prostacyclin Analogue on Survival in Patients With Chronic Thromboembolic Pulmonary Hypertension Without Major Vessel Obstruction

2003 • 87 citations

Ca/CaM-Stimulated and cGMP-Specific Phosphodiesterases in Vascular and Non-Vascular Tissues

1991 • 84 citations

Impact of pulmonary hypertension on outcome after single-lung transplantation

1994 • 84 citations

Reoperative pulmonary thromboendarterectomy

1999 • 83 citations

The influence of continuous intravenous prostacyclin therapy for primary pulmonary hypertension on the timing and outcome of transplantation.

1998 • 83 citations

Anaesthesia for caesarean section in the presence of severe primary pulmonary hypertension

1998 • 77 citations

Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed

1993 • 76 citations

Endothelium-Dependent Regulation of Resistance Arteries

1992 • 73 citations

The efficacy and tolerability of sildenafil in patients with moderate-to-severe pulmonary hypertension.

2003 • 73 citations

Preventive effect of an oral prostacyclin analog, beraprost sodium, on digital necrosis in systemic sclerosis. French Microcirculation Society Multicenter Group for the Study of Vascular Acrosyndromes.

1999 • 72 citations

Mid term effects of pulmonary thromboendarterectomy on clinical and cardiopulmonary function status

2002 • 72 citations

Primary pulmonary hypertension.

1975 • 72 citations

A study of clinical efficacy of sildenafil in patients with primary pulmonary hypertension.

2002 • 71 citations

Pulmonary hypertension, "plexogenic pulmonary arteriopathy" and the appetite depressant drug aminorex: post or propter?

1979 • 69 citations

Angioscopic video-assisted pulmonary endarterectomy for post-embolic pulmonary hypertension

1999 • 68 citations

Long-term results after thromboendarterectomy for chronic pulmonary embolism1

1999 • 68 citations

Endothelin-1: a Mediator of Pulmonary Hypertension?

1998 • 68 citations

Reperfusion injury in single-lung transplant recipients with pulmonary hypertension and emphysema.

1997 • 67 citations

Primary Pulmonary Hypertension In Israel

2001 • 65 citations

Hemodynamic Effects of Nonionic Contrast Bolus Injection and Oxygen Inhalation During Pulmonary Angiography in Patients With Chronic Major-Vessel Thromboembolic Pulmonary Hypertension

1996 • 64 citations

L‐arginine infusion has no effect on systemic haemodynamics in normal volunteers, or systemic and pulmonary haemodynamics in patients with elevated pulmonary vascular resistance.

1993 • 64 citations

Endothelin and Collagen Vascular Disease: A Review with Special Reference to Raynaud's Phenomenon and Systemic Sclerosis.

1994 • 63 citations

Prediction of Life Expectancy in Patients with Primary Pulmonary Hypertension. A Retrospective Nationwide Survey from 1980-1990.

1999 • 62 citations

Primary Pulmonary Hypertension and Pregnancy

1986 • 62 citations

Inhaled nitric oxide for primary pulmonary hypertension in pregnancy

2001 • 61 citations

Use of inhaled nitric oxide for emergency Cesarean section in a woman with unexpected primary pulmonary hypertension

2001 • 60 citations

Pathophysiology of pulmonary hypertension due to lung disease

2003 • 59 citations

Surgical Management of Unresolved Pulmonary Embolism

1995 • 58 citations

Effect of &lt;i&gt;L&lt;/i&gt;-Arginine Infusion on Infants with Persistent Pulmonary Hypertension of the Newborn

1995 • 58 citations

Lack of contribution of nitric oxide to basal vasomotor tone in heart failure

1994 • 57 citations

Heart-lung transplantation for primary pulmonary hypertension

1999 • 55 citations

Inhaled nitric oxide therapy in pregnancy complicated by pulmonary hypertension

1999 • 54 citations

Endothelial cell dysfunction correlates differentially with survival in primary and secondary pulmonary hypertension

2000 • 52 citations

Soluble Guanylyl Cyclase and Platelet Function^a

1994 • 51 citations

The Type III Phosphodiesterase Inhibitor Milrinone and Type V PDE Inhibitor Dipyridamole Individually and Synergistically Reduce Elevated Pulmonary Vascular Resistance

1994 • 49 citations

Dipyridamole Potentiates Pulmonary Vasodilation Induced by Acetylcholine and Nitric Oxide in the Ovine Fetus

1998 • 47 citations

Endothelium-Derived Nitric Oxide, Endothelin, and Platelet Vessel Wall Interaction: Alterations in Hypercholesterolemia and Atherosclerosis

1993 • 47 citations

Bosentan prevents hypoxia-reoxygenation–induced pulmonary hypertension and improves pulmonary function

1999 • 47 citations

Endothelium-Derived Relaxing Factor Modulates the Atherothrombogenic Effects of Homocysteine

1992 • 46 citations

Lung transplantation in children and young adults with cardiovascular disease

1995 • 46 citations

Acute hemodynamic effects of pulsed delivery of low flow nasal nitric oxide in children with pulmonary hypertension

1998 • 45 citations

Protective Effect of Beraprost Sodium, a Stable Prostacyclin Analogue, in Development of Monocrotaline-Induced Pulmonary Hypertension

1996 • 45 citations

Twin pregnancy in a woman on long-term epoprostenol therapy for primary pulmonary hypertension. A case report.

2000 • 45 citations

Bilateral sequential single lung transplantation for pulmonary hypertension and Eisenmenger’s syndrome

2000 • 45 citations

Conditional deficiencies of ornithine or arginine.

1986 • 43 citations

Ten years experience with lung and heart–lung transplantation in primary and secondary pulmonary hypertension✩

2000 • 42 citations

Inhaling Nitric Oxide: A Selective Pulmonary Vasodilator and Bronchodilator

1994 • 42 citations

Nitric oxide: Its identity and role in blood pressure control

1995 • 42 citations

Secondary pulmonary hypertension does not adversely affect outcome after single lung transplantation

2000 • 41 citations

Surgical Treatment for Chronic Thromboembolic Pulmonary Hypertension Under Profound Hypothermia and Circulatory Arrest in 24 Patients

1999 • 41 citations

The Free Amino Acids of Serum During Development of Macaca mulatto II. During Pregnancy and Fetal Life

1968 • 40 citations

Pulmonary vascular disorders masquerading as interstitial lung disease

1995 • 40 citations

Levels of free fatty acids and arachidonic acid in pregnancy and labor.

1980 • 40 citations

Glomerular thrombosis in pregnancy: Role of the L-arginine-nitric oxide pathway

1994 • 39 citations

Clinical significance of hyperbilirubinemia in patients with pulmonary hypertension undergoing heart-lung transplantation.

1991 • 37 citations

Perfusion lung scans provide a guide to which patients with apparent primary pulmonary hypertension merit angiography.

1988 • 37 citations

Surgical Treatment of Chronic Thromboembolic Pulmonary Hypertension

2000 • 36 citations

Cesarean section under epidural ropivacaine 0.75% in a parturient with severe pulmonary hypertension

2001 • 36 citations

Pulmonary hypertension in patients with severe obstructive sleep apnea

2002 • 35 citations

Identifying the Cause of Unilateral Hypoperfusion in Patients Suspected to Have Chronic Pulmonary Thromboembolism:Diagnostic Accuracy of Helical CT and Conventional Angiography

1999 • 34 citations

Short‐term Outcome and Predictors of Adverse Events following Pulmonary Thromboendarterectomy

1998 • 33 citations

Primary pulmonary hypertenson in pregnancy: A case report

1995 • 33 citations

Clinical relevance of endothelium‐derived relaxing factor (EDRF).

1992 • 32 citations

Carbohydrate and lipid metabolism during human labor: Free fatty acids, glucose, insulin, and lactic acid metabolism during normal and oxytocin-induced labor for postmaturity

1976 • 31 citations

Current early results of pulmonary thromboendarterectomy for chronic pulmonary embolism

1990 • 30 citations

Effects of repeated stress on plasma arginine levels in young and old rats

1993 • 30 citations

Identification of a Specific Transport System for L-Arginine in Human Platelets

1995 • 29 citations

The influence of fractional pulse pressure on the outcome of pulmonary thromboendarterectomy

2001 • 26 citations

Primary pulmonary hypertension: natural history and prognostic factors.

1994 • 25 citations

Effects of Intravenous Zaprinast and Inhaled Nitric Oxide on Pulmonary Hemodynamics and Gas Exchange in an Ovine Model of Acute Respiratory Distress Syndrome

2000 • 25 citations

Lack of beneficial effects of L-arginine infusion in primary pulmonary hypertension.

1994 • 24 citations

26. Pulmonary Hypertension Associated with Hepatic Cirrhosis

1990 • 23 citations

Alterations of plasma free fatty acids and glucose during labor

1967 • 22 citations

Endothelial dysfunction in chronic heart failure. Experimental and clinical studies.

1994 • 22 citations

Endothelial control of vascular and myocardial function in heart failure

1994 • 21 citations

�ber prim�re pulmonale Hypertonie im Kindesalter

1956 • 20 citations

Modulation of coronary autoregulatory responses by endothelium-derived nitric oxide

1995 • 17 citations

Surgical treatment for chronic pulmonary thromboembolism.

1989 • 16 citations

Positive inotropic and chronotropic effects of beraprost sodium, a stable analogue of prostacyclin, in isolated guinea pig myocardium

1996 • 15 citations

Long-term results of heart-lung transplantation for pulmonary hypertension

1997 • 15 citations

Bilateral lung transplantation for pulmonary hypertension

1997 • 14 citations

Survival and Prognostic Factors in Patients with Primary Pulmonary Hypertension

2001 • 11 citations

Pulmonary fat embolism presenting as chronic respiratory failure

1989 • 6 citations