Targeting Alloreactive Donor T-Cells to Hematopoietic System-Restricted Minor Histocompatibility Antigens to Dissect Graft-versus-Leukemia Effects from Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts

1979 • 1,538 citations

Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells

1999 • 1,218 citations

Treatment of High-Risk Acute Leukemia with T-Cell–Depleted Stem Cells from Related Donors with One Fully Mismatched HLA Haplotype

1998 • 1,200 citations

Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease

1995 • 772 citations

Mismatches of Minor Histocompatibility Antigens between HLA-Identical Donors and Recipients and the Development of Graft-Versus-Host Disease after Bone Marrow Transplantation

1996 • 603 citations

Acute graft-versus-host disease does not require alloantigen expression on host epithelium

2002 • 534 citations

Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with hematological diseases

2003 • 469 citations

The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism

1998 • 434 citations

Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

1995 • 429 citations

Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia

2003 • 420 citations

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

2001 • 373 citations

Human H-Y: a Male-Specific Histocompatibility Antigen Derived from the SMCY Protein

1995 • 358 citations

Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy

1997 • 346 citations

Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigens.

1992 • 320 citations

Feasibility of Immunotherapy of Relapsed Leukemia With Ex Vivo–Generated Cytotoxic T Lymphocytes Specific for Hematopoietic System-Restricted Minor Histocompatibility Antigens

1999 • 309 citations

In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens

2002 • 306 citations

The HLA-A*0201-Restricted H-Y Antigen Contains a Posttranslationally Modified Cysteine That Significantly Affects T Cell Recognition

1997 • 294 citations

Tetrameric HLA class I–minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

1999 • 277 citations

Cytotoxic T-Lymphocyte–Defined Human Minor Histocompatibility Antigens With a Restricted Tissue Distribution

1998 • 238 citations

A Human Minor Histocompatibility Antigen Specific for B Cell Acute Lymphoblastic Leukemia

1999 • 235 citations

Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region

2003 • 226 citations

CD8 ⁺ minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells

1999 • 215 citations

A Human Minor Histocompatibility Antigen Resulting from Differential Expression due to a Gene Deletion

2003 • 202 citations

Human minor histocompatibility antigens

1996 • 190 citations

The Immunogenicity of a New Human Minor Histocompatibility Antigen Results from Differential Antigen Processing

2001 • 188 citations

A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease

1983 • 179 citations

The Human UTY Gene Encodes a Novel HLA-B8-Restricted H-Y Antigen

2000 • 177 citations

The DBY gene codes for an HLA-DQ5–restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease

2002 • 158 citations

Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones

1994 • 156 citations

UTY gene codes for an HLA-B60–restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition

2000 • 151 citations

Cutting Edge: The HLA-A*0101-Restricted HY Minor Histocompatibility Antigen Originates fromDFFRYand Contains a Cysteinylated Cysteine Residue as Identified by a Novel Mass Spectrometric Technique

1999 • 150 citations

Growth inhibition of clonogenic leukemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes.

1991 • 141 citations

Correlation Between Disparity for the Minor Histocompatibility Antigen HA-1 and the Development of Acute Graft-Versus-Host Disease After Allogeneic Marrow Transplantation

1999 • 139 citations

Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor immunotherapy

1996 • 131 citations

Female donors influence transplant-related mortality and relapse incidence in male recipients of sibling blood and marrow transplants

2001 • 130 citations

The HA-2 Minor Histocompatibility Antigen Is Derived from a Diallelic Gene Encoding a Novel Human Class I Myosin Protein

2001 • 124 citations

DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection

2000 • 116 citations

Generation of human tumor-reactive cytotoxic T cells against peptides presented by non-self HLA class I molecules

1998 • 110 citations

The minor histocompatibility antigen HA-3 arises from differential proteasome–mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein

2003 • 107 citations

Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL.

1997 • 107 citations

The Hematopoietic System–specific Minor Histocompatibility Antigen HA-1 Shows Aberrant Expression in Epithelial Cancer Cells

2002 • 89 citations

Specific depletion of alloreactive T cells in HLA‐identical siblings: a method for separating graft‐versus‐host and graft‐versus‐leukaemia reactions

1998 • 79 citations

Identification of a Novel HLA-B60-Restricted T Cell Epitope of the Minor Histocompatibility Antigen HA-1 Locus

2002 • 79 citations

Generation of minor histocompatibility antigen HA-1–specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation

2002 • 65 citations

Long-term follow-up of recipients of CD8-depleted donor lymphocyte infusions for the treatment of chronic myelogenous leukemia relapsing after allogeneic progenitor cell transplantation

2001 • 61 citations

Bi-directional allelic recognition of the human minor histocompatibility antigen HB-1 by cytotoxic T lymphocytes

2002 • 60 citations

Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity

2003 • 58 citations

Efficient induction of minor histocompatibility antigen HA-1-specific cytotoxic T-cells using dendritic cells retrovirally transduced with HA-1-coding cDNA

2002 • 42 citations

Adoptive transfer of T-cell immunity

2002 • 36 citations

How much benefit can be expected from matching for minor antigens in allogeneic marrow transplantation?

1997 • 29 citations

Induction of minor histocompatibility antigen—specific T-helper but not T-cytotoxic response is dependent on the source of antigen-presenting cell

1990 • 10 citations

Deleted Work

1955 • 0 citations

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