Co-Stimulatory Requirements of Effector T Cells at Inflammatory Sites

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

T cell co-stimulatory molecules other than CD28

1999 • 349 citations

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

2000 • 284 citations

The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE

2001 • 264 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

Accessory Molecule and Costimulation Requirements for CD4 T Cell Response

1997 • 231 citations

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

1999 • 219 citations

Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis.

1992 • 202 citations

Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.

1996 • 201 citations

Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.

1998 • 198 citations

IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice.

1992 • 194 citations

Herpes simplex virus-induced stromal keratitis: role of T-lymphocyte subsets in immunopathology

1989 • 148 citations

Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas.

1996 • 132 citations

Critical role of corneal Langerhans cells in the CD4- but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas.

1992 • 130 citations

Inducible Costimulator Regulates Th2-Mediated Inflammation, but Not Th2 Differentiation, in a Model of Allergic Airway Disease

2001 • 127 citations

Proinflammatory functions of IL-2 in herpes simplex virus corneal infection.

1997 • 100 citations

The amplification of TCR signaling by dynamic membrane microdomains

2001 • 100 citations

Role of CD28/CD80-86 and CD40/CD154 Costimulatory Interactions in Host Defense to Primary Herpes Simplex Virus Infection

2001 • 61 citations

B7 Costimulatory Requirements of T Cells at an Inflammatory Site

1998 • 58 citations

Presence of Langerhans cells in the central cornea linked to the development of ocular herpes in mice

1992 • 38 citations

Ex vivo model of leukocyte migration into herpes simplex virus-infected mouse corneas

1996 • 30 citations

Immunohistochemical detection of cytokines in paraffin-embedded mouse tissues

1997 • 27 citations

The relationship of corneal Langerhans cells to herpes simplex antigens during dendritic keratitis

1989 • 23 citations