Human T cell antigens involved in cytotoxicity against allogeneic or autologous chemically modified targets. Association of the Leu 2a/T8 antigen with effector‐target cell binding and of the T3/Leu 4 antigen with triggering

Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

1979 • 1,480 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.

1982 • 740 citations

A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.

1980 • 719 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

Further Characterization of the Human Inducer T Cell Subset Defined by Monoclonal Antibody

1979 • 610 citations

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

1982 • 600 citations

OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.

1980 • 525 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor

1983 • 464 citations

Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex.

1975 • 381 citations

Thymus-dependent membrane antigens in man: Inhibition of cell-mediated lympholysis by monoclonal antibodies to T _{H 2} antigen

1981 • 352 citations

Studies of a human T lymphocyte antigen recognized by a monoclonal antibody.

1981 • 349 citations

ANTIGENIC MODULATION

1968 • 322 citations

A human lymphocyte‐associated antigen involved in cell‐mediated lympholysis

1983 • 315 citations

Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells?

1981 • 306 citations

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

1982 • 306 citations

Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man.

1981 • 304 citations

Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions.

1981 • 292 citations

Lymphocyte stimulation by protein A of Staphylococcus aureus

1976 • 268 citations

Mechanism of Specific Tumor-Cell Lysis by Alloimmune T Lymphocytes: Resolution and Characterization of Discrete Steps in the Cellular Interaction

1977 • 258 citations

A monoclonal antibody blocking human T cell function

1980 • 239 citations

Surface Structures Involved in Target Recognition by Human Cytotoxic T Lymphocytes

1982 • 238 citations

Inhibition of murine T cell‐mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94000 and 180000 molecular weight

1982 • 237 citations

Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.

1982 • 237 citations

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

1981 • 234 citations

LFA‐1 and Lyt‐2,3, Molecules Associated with T Lymphocyte‐Mediated Killing; and Mac‐1, an LFA‐1 Homologue Associated with Complement Receptor Function¹

1982 • 223 citations

Mechanism of cell-mediated cytotoxicity at the single cell level. I. Estimation of cytotoxic T lymphocyte frequency and relative lytic efficiency.

1979 • 217 citations

Concanavalin A triggers T lymphocytes by directly interacting with their receptors for activation.

1982 • 211 citations

Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera

1979 • 208 citations

Human cytotoxic T cell structures associated with expression of cytolysis. I. Analysis at the clonal cell level of the cytolysis‐inhibiting effect of 7 monoclonal antibodies

1982 • 194 citations

Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies.

1982 • 185 citations

The delineation of antigen receptors on human T lymphocytes

1983 • 162 citations

Hybridomas in Cancer Diagnosis and Treatment

1982 • 161 citations

Abnormal T lymphocyte subpopulations in patients with B cell chronic lymphocytic leukemia: an analysis by monoclonal antibodies.

1982 • 160 citations

Mechanism of Cell-Mediated Cytotoxicity at the Single Cell Level

1979 • 152 citations

Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus.

1979 • 146 citations

Interaction of Cytotoxic T Lymphocytes and Target Cells

2015 • 139 citations

Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. I. Resolution and characterization.

1975 • 137 citations

Specificity of OKT4+ cytotoxic T lymphocyte clones.

1982 • 136 citations

Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures.

1983 • 133 citations

GENETIC CORRELATION OF A MOUSE LIGHT CHAIN VARIABLE REGION MARKER WITH A THYMOCYTE SURFACE ANTIGEN

1974 • 130 citations

Defective spontaneous and antibody-dependent cytotoxicity mediated by E-rosette-positive and E-rosette-negative cells in untreated patients with chronic lymphocytic leukemia: augmentation by in vitro treatment with interferon.

1980 • 130 citations

Cellular origin and interactions involved in gamma-interferon production induced by OKt3 monoclonal antibody.

1982 • 129 citations

Two monoclonal anti-human T lymphocyte antibodies have similar biologic effects and recognize the same cell surface antigen.

1982 • 123 citations

The role of T cell differentiation markers in antigen-specific and lectin-dependent cellular cytotoxicity mediated by T8+ and T4+ human cytotoxic T cell clones directed at class I and class II MHC antigens.

1982 • 121 citations

Carboxyfluorescein fluorochromasia assays. I. Non-radio actively labeled cell mediated lympholysis

1980 • 116 citations

Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes

1981 • 115 citations

Blocking effect of lyt-2 antibodies on T cell functions.

1980 • 114 citations

Early Steps in Specific Tumor Cell Lysis by Sensitized Mouse T Lymphocytes

1975 • 109 citations

Mechanism of T-Cell-Mediated Cytolysis: The Lethal Hit Stage

1977 • 105 citations

Inhibition of specific cell-mediated cytotoxicity by monoclonal antibodies to human T cell antigens

1981 • 105 citations

INTERSTITIAL IMMUNE COMPLEX THYROIDITIS IN MICE

1974 • 98 citations

Human gamma interferon production by leukocytes induced with monoclonal antibodies recognizing T cells.

1981 • 85 citations

T-Cell-Mediated Cytolysis: An Overview of Some Current Issues

1977 • 81 citations

Xenogeneic human anti-mouse T cell responses are due to the activity of the same functional T cell subsets responsible for allospecific and major histocompatibility complex-restricted responses.

1983 • 77 citations

Lyt-2-/Lyt 3- variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis.

1981 • 74 citations

Evidence for Close Linkage of a Mouse Light Chain Marker with the LY-2,3 Locus

1978 • 73 citations

Molecular interactions in human T cell-mediated cytotoxicity to EBV II. Monoclonal antibody OKT3 inhibits a post-killer-target recognition/adhesion step.

1982 • 69 citations

Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.

1976 • 69 citations

Studies on the induction and expression of T cell-mediated immunity. X. Inhibition by Lyt 2,3 antisera of cytotoxic T lymphocyte-mediated antigen-specific and -nonspecific cytotoxicity: evidence for the blocking of the binding between T lymphocytes and target cells and not the post-binding cytolytic steps.

1980 • 63 citations

Long term use of intravenous immune globulin in patients with primary immunodeficiency diseases: Inadequacy of current dosage practices and approaches to the problem

1982 • 57 citations

Human cytotoxic response in vitro to trinitrophenyl-modified autologous cells. I. T cell recognition of TNP in association with widely shared antigens.

1978 • 50 citations

Studies on the induction and expression of T cell-mediated immunity. XI. Inhibition of the "lethal hit" in T cell-mediated cytotoxicity by heterologous rat antiserum made against alloimmune cytotoxic T lymphocytes.

1981 • 34 citations

Human cytotoxic response in vitro to trinitrophenyl-modified autologous cells. II. Diversity of self determinants recognized in association with TNP.

1978 • 29 citations

Mouse alloantibodies capable of blocking cytotoxic T cell function. III. Studies of the mechanism of blocking of CML by anti-Lyt-2 antibodies.

1981 • 22 citations

Human Cytotoxic Response in Vitro to Trinitrophenyl-Modified Autologous Cells

1978 • 22 citations

Human Cytotoxic Response in Vitro to Trinitrophenyl-Modified Autologous Cells

1978 • 20 citations

Two distinct phenotypes of HLA-DR-specific cytotoxic T-cell lines

1983 • 17 citations

Monoclonal antibody to Lyt 2 antigen blocks H–2I- and H–2K- specific mouse cytotoxic T cells

1982 • 17 citations

Molecular interactions in human T-cell-mediated cytotoxicity to Epstein-Barr virus

1982 • 15 citations

The in vitro cellular response of human lymphocytes totrinitrophenylated autologous cells: HLA‐D restrictionof proliferation but apparent absence of HLArestriction of cytolysis

1979 • 13 citations

Cell-Mediated Immunity to Viral Glycoproteins

1980 • 11 citations