Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

1989 • 437 citations

Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

1989 • 433 citations

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

1992 • 395 citations

Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.

1987 • 307 citations

Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.

1991 • 288 citations

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals

1988 • 270 citations

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins

1983 • 252 citations

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease.

1991 • 249 citations

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogs of Alzheimer amyloid .beta.-protein

1992 • 244 citations

A4 Protein in Alzheimer's Disease: Primary and Secondary Cellular Events in Extracellular Amyloid Deposition

1989 • 236 citations

Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques

1989 • 233 citations

A Simple Azo-Dye Method for Histochemical Demonstration of Acid Phosphatase

1960 • 224 citations

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

1990 • 168 citations

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

1991 • 165 citations

Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia

1967 • 163 citations

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1990 • 154 citations

The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects

1989 • 142 citations

Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain.

1989 • 140 citations

Kunitz Protease Inhibitor-Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease

1992 • 137 citations

Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain

1989 • 125 citations

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

1992 • 120 citations

THE IMMUNOHISTOCHEMICAL DEMONSTRATION OF SUBSEQUENCES OF THE PRECURSOR OF THE AMYLOID A4 PROTEIN IN SENILE PLAQUES IN ALZHEIMER'S DISEASE

1989 • 119 citations

Amyloid β-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia

1990 • 100 citations

Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease

1990 • 100 citations

Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain

1990 • 89 citations

Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease.

1991 • 87 citations

Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques.

1991 • 86 citations

DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type)

1991 • 77 citations

AN ANALYSIS OF THE MORPHOLOGY OF SENILE PLAQUES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES USING IMMUNOCYTOCHEMICAL AND LECTIN HISTOCHEMICAL TECHNIQUES

1989 • 74 citations

Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease.

1993 • 69 citations

Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions

1992 • 69 citations

Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease

1991 • 68 citations

Accumulation of amyloid precursor fragment in Alzheimer plaques

1991 • 67 citations

Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex

1989 • 65 citations

Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease.

1992 • 58 citations

The Amyloid Precursor-like Protein (APLP) Gene Maps to the Long Arm of Human Chromosome 19

1993 • 56 citations

Secretory Form of Alzheimer Amyloid Precursor Protein 695 in Human Brain Lacks β/A4 Amyloid Immunoreactivity

1993 • 38 citations

Hereditary cerebral hemorrhage with amyloidosis — Dutch type

1989 • 35 citations

Morphology of cerebral plaque-like lesions in hereditary cerebral hemorrhage with amyloidosis (Dutch)

1992 • 31 citations

Ubiquitin-immunoreactive Dystrophic Neurites in Downʼs Syndrome Brains

1991 • 28 citations

Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy

1992 • 25 citations

Alzheimer's amyloid precursor protein-positive degenerative neurites exist even within kuru plaques not specific to Alzheimer's disease.

1991 • 24 citations

Ubiquitinated neurites are associated with preamyloid and cerebral amyloid ? deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type

1993 • 15 citations

Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities

1992 • 12 citations

Dr. G. H. Francis

1960 • 1 citations