Studies of surface immunoglobulin-dependent B cell activation

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

1984 • 785 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

Viral and cellular fos proteins: A comparative analysis

1984 • 523 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

STUDIES ON RABBIT LYMPHOCYTES IN VITRO

1965 • 418 citations

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1984 • 410 citations

Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.

1983 • 394 citations

Lymphocyte stimulation: a rapid multiparameter analysis.

1976 • 363 citations

B lymphocyte receptors and polyphosphoinositide degradation

1985 • 332 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

New cell cycle compartments identified by multiparameter flow cytometry

1980 • 319 citations

Frequency of B lymphocytes responsive to anti-immunoglobulin.

1982 • 302 citations

Interleukin-induced increase in Ia expression by normal mouse B cells.

1984 • 293 citations

Nuclear Localization and DNA Binding Properties of a Protein Expressed by Human c- myc Oncogene

1984 • 288 citations

Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters

1980 • 274 citations

Inositol phospholipids in membrane function

1979 • 272 citations

Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes.

1985 • 257 citations

Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate

1977 • 256 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Immune Activation of B Cells: Evidence for‘One Nonspecific Triggering Signal' Not Delivered by the Ig Receptors

1974 • 244 citations

Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Lipids in search of a function

1982 • 242 citations

Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

1986 • 241 citations

Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes.

1982 • 223 citations

Inositol(1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver

1984 • 193 citations

T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.

1980 • 191 citations

Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.

1986 • 182 citations

B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis.

1984 • 180 citations

Phospholipid Turnover in Hormone Action

1984 • 178 citations

Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas

1986 • 177 citations

Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin.

1981 • 176 citations

Induction and Suppression of Polyclonal Antibody Responses by Anti‐Ig Reagents and Antigen‐Nonspecific Helper Factors:

1980 • 169 citations

The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by anti-immunoglobulin antibodies.

1981 • 158 citations

Relationship between enhanced turnover of phosphatidylinositol and lymphocyte activation by mitogens

1975 • 153 citations

Induction of c-fos and c-myc mRNA by epidermal growth factor or calcium ionophore is cAMP dependent.

1986 • 151 citations

Interferon regulates c-myc gene expression in Daudi cells at the post-transcriptional level.

1985 • 149 citations

Antigen presentation by splenic B cells: resting B cells are ineffective, whereas activated B cells are effective accessory cells for T cell responses.

1985 • 145 citations

Regulation of c-myc mRNA levels in normal human lymphocytes by modulators of cell proliferation.

1985 • 144 citations

Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes.

1986 • 136 citations

The isolation of a new lipid, triphosphoinositide, and monophosphoinositide from ox brain

1961 • 135 citations

Role of membrane immunoglobulin (Ig) crosslinking in membrane Ig-mediated, major histocompatibility-restricted T cell-B cell cooperation.

1985 • 131 citations

Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.

1983 • 129 citations

Dissociation of two signals required for activation of resting B cells.

1982 • 123 citations

Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes.

1986 • 121 citations

T cell-dependent activation of resting B cells: requirement for both nonspecific unrestricted and antigen-specific Ia-restricted soluble factors.

1981 • 115 citations

Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase

1983 • 114 citations

B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes.

1983 • 112 citations

The Structure of the Phosphoinositide Complex of Beef Brain

1961 • 110 citations

Effects of Anti‐Ig Antibodies on the Development and Differentiation of B Cells

1980 • 110 citations

B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled.

1983 • 101 citations

Potentiation of growth factor activity by exogenous c-myc expression.

1986 • 99 citations

Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.

1980 • 94 citations

Separate control of B lymphocyte early activation and proliferation in response to anti-IgM antibodies.

1985 • 93 citations

B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation.

1984 • 93 citations

The Use of Anti‐immunoglobulins to Induce a Signal for Cell Division in B Lymphocytes via their Membrane IgM and IgD

1980 • 90 citations

Role of the major histocompatibility complex in T cell activation of B cell subpopulations. lyb-5(+) and lyb-5(-) B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition

1981 • 82 citations

Molecular events in B cell activation. I. Signals required to stimulate G0 to G1 transition of resting B lymphocytes.

1985 • 80 citations

Renewed interest in the polyphosphoinositides

1984 • 80 citations

Activation of murine B lymphocytes by anti-immunoglobulin is an inductive signal leading to immunoglobulin secretion.

1980 • 77 citations

Membrane IgM, IgD, and IgG act as signal transmission molecules in a series of B lymphomas.

1986 • 75 citations

Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle.

1983 • 75 citations

Lymphoma models for B-cell activation and tolerance

1985 • 69 citations

B cell activation. V. Differentiation signaling of B cell membrane depolarization, increased I-A expression, G0 to G1 transition, and thymidine uptake by anti-IgM and anti-IgD antibodies.

1984 • 68 citations

B lymphocyte activation: Entry into cell cycle is accompanied by decreased expression of IgD but not IgM

1983 • 66 citations

The biochemical basis of transmembrane signalling by B lymphocyte surface immunoglobulin

1985 • 66 citations

Comparative subunit composition of the eukaryotic nuclear RNA polymerases

1981 • 62 citations

B cell activation. VII. Independent and synergistic effects of mobilized calcium and diacylglycerol on membrane potential and I-A expression.

1986 • 61 citations

Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium.

1986 • 59 citations

B cell activation. VI. Effects of exogenous diglyceride and modulators of phospholipid metabolism suggest a central role for diacylglycerol generation in transmembrane signaling by mIg.

1985 • 58 citations

Single cell analysis of calcium mobilization in anti-immunoglobulin-stimulated B lymphocytes.

1986 • 57 citations

Roles of Surface‐Bound Immunoglobulin Molecules in Regulating the Replication and Maturation to Immunoglobulin Secretion of B Lymphocytes

1980 • 54 citations

Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-delta antibody that induces allotype-specific proliferation.

1980 • 51 citations

B Lymphocyte Biology Studied with Anti‐Ig Antibodies

1980 • 50 citations

Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni

1985 • 48 citations

The Theory of the‘One Nonspecific Signal’Model for B Cell Activation

1975 • 45 citations

Subpopulations of B cells distinguished by cell surface expression of Ia antigens. Correlation of Ia and idiotype during activation by cloned Ia-restricted T cells.

1983 • 44 citations

Induction of murine B cell proliferation by insolubilized anti-immunoglobulins.

1980 • 43 citations

Use of the T Lymphocyte Regulated Type 2 Antigens for the Analysis of Responsiveness of Lyb5⁺ and Lyb5⁻ B Lymphocytes to T Lymphocyte Derived Factors

1982 • 41 citations

The biosynthesis of triphosphoinositide by rat brain in vitro

1966 • 40 citations

A phosphatidylinositol kinase in rat mast cell granules.

1986 • 40 citations

Induction of the c-myc protooncogene after antigen binding to hapten-specific B cells.

1986 • 39 citations

Supernatant from a cloned helper T cell stimulates most small resting B cells to undergo increased I-A expression, blastogenesis, and progression through cell cycle.

1986 • 38 citations

Sorting of B lymphoblasts based upon cell diameter provides cell populations enriched in different stages of cell cycle

1983 • 37 citations

Role of membrane receptors in the induction of an in vitro secondary anti‐hapten response I. Differentiation of B memory cells to plasma cells is independent of antigen‐immunoglobulin receptor interaction

1978 • 36 citations

Role of cell surface immunoglobulin in B-lymphocyte activation.

1984 • 36 citations

Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells.

1982 • 32 citations

Expression and function of I region products on immunocompetent cells. II. I region products in T-B interaction.

1977 • 30 citations

Allotypes of IgM and IgD Receptors in the Mouse: A Probe for Lymphocyte Differentiation

1978 • 29 citations

Expression and Function of I Region Products on Immunocompetent Cells

1977 • 21 citations

Studies on rabbit lymphocytes in vitro. XII. Augmentation of anti-allotypic blast transformation by a second anti-allotypic serum directed against the primary stimulating anti-allotypic serum (piggy-back effect).

1970 • 20 citations

Role of membrane receptors in the induction of an in vitro secondary anti‐hapten response II. Antigen‐immunoglobulin receptor interaction is not required for B memory cell proliferation

1978 • 14 citations

Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell.

1985 • 13 citations

Activation of rat B lymphocytes. I. Characterization of anti-immunoglobulin responses and isotype density of rat B cells.

1982 • 11 citations

GENETIC ASPECTS OF IgD EXPRESSION: III. FUNCTIONAL IMPLICATIONS OF THE SEQUENCE AND ORGANIZATION OF THE Cδ GENE

1982 • 11 citations

Immunoregulation of T-dependent responses by a cloned dendritic cell.

1984 • 10 citations

Comparison of protein phosphorylation induced by mitogen and phorbol diester stimulation of murine T and B lymphocytes

1985 • 8 citations

The role of immunoglobulin receptors and T cell mediators in B lymphocyte activation. I. B cell activation by anti-immunoglobulin and anti-idiotype reagents.

1980 • 6 citations

The role of immunoglobulin receptors and T cell mediators in B lymphocyte activation. I. B cell activation by anti-immunoglobulin and anti-idiotype reagents

1980 • 6 citations