Adverse psychological impact, glutamatergic dysfunction, and risk factors for Alzheimer's disease

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Failure to escape traumatic shock.

1967 • 1,860 citations

Stress and cognitive function

1995 • 1,830 citations

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

1996 • 1,734 citations

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

1989 • 1,505 citations

BINOCULAR INTERACTION IN STRIATE CORTEX OF KITTENS REARED WITH ARTIFICIAL SQUINT

1965 • 1,377 citations

Influence of Education and Occupation on the Incidence of Alzheimer's Disease

1994 • 1,373 citations

Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons

1992 • 1,215 citations

Education and the prevalence of dementia and Alzheimer's disease

1993 • 1,154 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Hippocampal damage associated with prolonged glucocorticoid exposure in primates

1990 • 1,092 citations

Organization of Behavior.

1950 • 1,082 citations

Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons

1990 • 1,013 citations

The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education

1990 • 977 citations

Psychobiology of plasticity: effects of training and experience on brain and behavior

1996 • 953 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Repeated stress causes reversible impairments of spatial memory performance

1994 • 760 citations

Hippocampal damage associated with prolonged and fatal stress in primates

1989 • 746 citations

The Cholinergic Synapse and the Site of Memory

1972 • 741 citations

Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

1984 • 729 citations

Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study

1980 • 700 citations

NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus

1989 • 654 citations

An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses.

1994 • 603 citations

Acetylcholine: a neurotransmitter for learning and memory?

1995 • 601 citations

Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

1991 • 582 citations

Stress Preferentially Increases Extraneuronal Levels of Excitatory Amino Acids in the Prefrontal Cortex: Comparison to Hippocampus and Basal Ganglia

1993 • 565 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

Depressed Mood and the Incidence of Alzheimer's Disease in the Elderly Living in the Community

1996 • 550 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Effects of environmental complexity and training on brain chemistry and anatomy: A replication and extension.

1962 • 496 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation.

1996 • 435 citations

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1990 • 428 citations

Long-Term Synaptic Potentiation

1988 • 417 citations

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

1990 • 396 citations

Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings

1991 • 383 citations

Glutamate dysfunction in Alzheimer's disease: an hypothesis

1987 • 335 citations

Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes

1989 • 325 citations

Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord

1991 • 296 citations

The Role of Glutamate in Neurotransmission and in Neurologic Disease

1986 • 294 citations

Learning and memory in combat veterans with posttraumatic stress disorder

1995 • 289 citations

Prevalence and prognostic significance of exercise-induced silent myocardial ischemia detected by thallium scintigraphy and electrocardiography in asymptomatic volunteers.

1990 • 266 citations

Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography

1992 • 254 citations

Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats

1991 • 251 citations

Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam

1997 • 235 citations

Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

1993 • 233 citations

History of Depression as a Risk Factor for Alzheimerʼs Disease

1995 • 229 citations

Effect of Acute Stress on Hippocampal Glutamate Levels and Spectrin Proteolysis in Young and Aged Rats

1995 • 219 citations

Age-related decreases of the N-methyl-d-aspartate receptor complex in the rat cerebral cortex and hippocampus

1991 • 212 citations

Do glucocorticoid concentrations rise with age in the rat?

1992 • 209 citations

Influence of education and occupation on the incidence of Alzheimer's disease

1994 • 205 citations

Environmental influences on the central nervous system and their implications for the aging rat

1993 • 203 citations

Familial Aggregation of Alzheimer's Disease and Related Disorders: A Collaborative Re-Analysis of Case-Control Studies

1991 • 203 citations

The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression

1995 • 188 citations

Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression

1995 • 186 citations

Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?

1990 • 168 citations

Glucocorticoids Exacerbate Kainic Acid–Induced Extracellular Accumulation of Excitatory Amino Acids in the Rat Hippocampus

1992 • 154 citations

d-Cycloserine enhances implicit memory in Alzheimer patients

1996 • 150 citations

The epidemiology of Alzheimer's disease and related disorders

1990 • 128 citations

Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate

1985 • 128 citations

Region-selective stress-induced increase of glutamate uptake and release in rat forebrain

1990 • 126 citations

Experience, memory, and the brain.

1984 • 125 citations

Exposure to chronic psychosocial stress and corticosterone in the rat: Effects on spatial discrimination learning and hippocampal protein kinase C? immunoreactivity

1997 • 124 citations

Cognitive decline associated with normal aging in rats: a neuropsychological approach.

1995 • 115 citations

Cerebral ischemia: Are the memory deficits associated with hippocampal cell loss?

1996 • 107 citations

The Pharmacotherapy of Alzheimer's Disease Based on the Cholinergic Hypothesis: an Update

1995 • 104 citations

Glutamatergic Control of Dopamine Release During Stress in the Rat Prefrontal Cortex

1994 • 99 citations

Effects of NMDA Modulation in Scopolamine Dementiaa

1991 • 87 citations

REGIONAL NEURONE DAMAGE AFTER CEREBRAL ISCHAEMIA IN THE NORMO‐ AND HYPOGLYCAEMIC RAT

1981 • 86 citations

Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease

1992 • 76 citations

Decreased density, but not number, N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats

1990 • 70 citations

Reduced density of NMDA receptors and increased sensitivity to dizocilpine-induced learning impairment in aged rats

1992 • 68 citations

Plasma apolipoproteins in patients with multi-infarct dementia

1989 • 65 citations

Competitive antagonism of glycine at the N-methyl-d-aspartate (NMDA) receptor

1991 • 62 citations

Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats

1986 • 62 citations

Evaluation of Cycloserine in the Treatment of Alzheimer's Disease

1995 • 49 citations

A chronic physiological rat model of dementia

1994 • 48 citations

Dimensions of discrimination and level of cholinesterase activity in the cerebral cortex of the rat.

1956 • 47 citations

ApoE4 polymorphism increases the risk for exercise-induced silent myocardial ischemia in older men.

1993 • 43 citations

Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia

2009 • 42 citations

Injury‐induced Synthesis and Release of Apolipoprotein E and Clusterin from Rat Neural Cells

1996 • 40 citations

Animal models of Alzheimer's disease: Glutamatergic denervation as an alternative approach to cholinergic denervation

1993 • 39 citations

Role of Glutamate and Glutamate Receptors in Memory Function and Alzheimer's Disease^a

1995 • 39 citations

Memory dysfunction following disruption of glutamergic systems in the temporal region of the rat: effects of agonistic amino acids

1992 • 38 citations

Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats

1997 • 36 citations

Caring for a parent with Alzheimer's disease: process of daughter caregiver stress

1996 • 35 citations

Impaired reference memory and reduced glutamergic activity in rats with temporo-entorhinal connections disrupted

1989 • 27 citations

Selective lesions in the temporal—hippocampal region of the rat: effects on acquisition and retention of a visual discrimination task

1992 • 26 citations

Differential rearing conditions in rats: Effects on neurochemistry in neocortical areas and cognitive behaviors

1992 • 25 citations

Retroactive memory of a visual discrimination task in the rat: role of temporal-entorhinal cortices and their connections

1991 • 19 citations

Salt seeking by food selection in adrenalectomized rats.

1973 • 15 citations

Memory impairment in rats with glutamatergic temporal systems disrupted is attenuated by D-cycloserine: Effects of postoperative time of injection

1995 • 12 citations

Clinical correlations of the neurobiological changes of aging.

1990 • 7 citations

Excitatory Transmitter Neurotoxicity and Alzheimer’s Disease

1994 • 5 citations

Triumph Then Despair

1994 • 4 citations