The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription

The language of covalent histone modifications

2000 • 8,260 citations

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

Visualization of Interactions among bZIP and Rel Family Proteins in Living Cells Using Bimolecular Fluorescence Complementation

2002 • 1,516 citations

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

1998 • 1,213 citations

Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4

2005 • 1,073 citations

Integrating mRNA Processing with Transcription

2002 • 1,054 citations

Structure and Function of a Human TAF _II 250 Double Bromodomain Module

2000 • 808 citations

Elongation by RNA polymerase II: the short and long of it

2004 • 701 citations

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

2001 • 680 citations

P-TEFb, a Cyclin-Dependent Kinase Controlling Elongation by RNA Polymerase II

2000 • 671 citations

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

2001 • 670 citations

Flavopiridol Inactivates P-TEFb and Blocks Most RNA Polymerase II Transcription in Vivo

2001 • 638 citations

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

2003 • 635 citations

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.

1996 • 556 citations

Histone-like TAFs within the PCAF Histone Acetylase Complex

1998 • 534 citations

Identification of multiple cyclin subunits of human P-TEFb

1998 • 512 citations

Inhibition of P-TEFb (CDK9/Cyclin T) Kinase and RNA Polymerase II Transcription by the Coordinated Actions of HEXIM1 and 7SK snRNA

2003 • 454 citations

NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II

2001 • 431 citations

Selective Recognition of Acetylated Histones by Bromodomain Proteins Visualized in Living Cells

2004 • 353 citations

P-TEFb kinase recruitment and function at heat shock loci

2000 • 309 citations

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

1998 • 305 citations

Growth and Early Postimplantation Defects in Mice Deficient for the Bromodomain-Containing Protein Brd4

2002 • 305 citations

A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G₂-to-M Transition

2000 • 281 citations

Tat Modifies the Activity of CDK9 To Phosphorylate Serine 5 of the RNA Polymerase II Carboxyl-Terminal Domain during Human Immunodeficiency Virus Type 1 Transcription

2000 • 260 citations

Bromodomains Mediate an Acetyl-Histone Encoded Antisilencing Function at Heterochromatin Boundaries

2003 • 233 citations

MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner

2003 • 226 citations

Cyclin K Functions as a CDK9 Regulatory Subunit and Participates in RNA Polymerase II Transcription

1999 • 221 citations

Different Sensitivities of Bromodomain Factors 1 and 2 to Histone H4 Acetylation

2003 • 184 citations

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

2003 • 179 citations

Phosphorylated Positive Transcription Elongation Factor b (P-TEFb) Is Tagged for Inhibition through Association with 7SK snRNA

2004 • 169 citations

A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase

2002 • 167 citations

RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F.

2000 • 156 citations

The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions

2001 • 124 citations

Interaction between P-TEFb and the C-Terminal Domain of RNA Polymerase II Activates Transcriptional Elongation from Sites Upstream or Downstream of Target Genes

2002 • 108 citations

Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization

2004 • 73 citations

Physical interaction between pRb and cdk9/cyclinT2 complex

2002 • 67 citations

Reproductive Cycle Regulation of Nuclear Import, Euchromatic Localization, and Association with Components of Pol II Mediator of a Mammalian Double-Bromodomain Protein

2002 • 49 citations