Lessons learned from clinical trials of sepsis

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Pathogenetic Mechanisms of Septic Shock

1993 • 1,577 citations

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1994 • 920 citations

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

1995 • 805 citations

A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis

1991 • 741 citations

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

1994 • 714 citations

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebocontrolled multicenter trial

1994 • 488 citations

Treatment of Septic Shock with Human Monoclonal Antibody HA-1A

1994 • 474 citations

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

1993 • 427 citations

An overview of mortality risk prediction in sepsis

1995 • 251 citations

Transmission of Hepatitis A to Patients with Hemophilia by Factor VIII Concentrates Treated with Organic Solvent and Detergent To Inactivate Viruses

1994 • 247 citations

Platelet-activating factor receptor antagonist BN 52021 in the treatment of severe sepsis: A randomized, double-blind, placebo-controlled, multicenter clinical trial

1994 • 238 citations

Anti-Endotoxin Monoclonal Antibodies

1992 • 235 citations

Platelet-activating factor receptor antagonist BN 52021 in the treatment of severe sepsis: A randomized, double-blind, placebo-controlled, multicenter clinical trial

1994 • 204 citations

Differential Expression of Proinflammatory Cytokines and Their Inhibitors during the Course of Meningococcal Infections

1994 • 175 citations

Round table conference on clinical trials for the treatment of sepsis

1995 • 98 citations

Minireview: Therapeutic intervention in sepsis with antibody to endotoxin: is there a future?

1994 • 67 citations

Efficacy of antilipopolysaccharide and anti-tumor necrosis factor monoclonal antibodies in a neutropenic rat model of Pseudomonas sepsis.

1991 • 64 citations

Why have new effective therapies for sepsis not been developed?

1994 • 58 citations

Peripheral and liver tissue oxygen tensions in hemorrhagic shock

1992 • 23 citations

Hormone and Cytokine Regulation of Injury Metabolism

1993 • 9 citations