STRUCTURE/FUNCTION CHARACTERIZATION OF PORCINE CD59

CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.

1989 • 640 citations

The PiGMaP consortium linkage map of the pig (Sus scrofa)

1995 • 439 citations

The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9.

1990 • 403 citations

Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis

1995 • 318 citations

TRANSGENIC PIGS EXPRESSING HUMAN CD59 AND DECAY-ACCELERATING FACTOR PRODUCE AN INTRINSIC BARRIER TO COMPLEMENT-MEDIATED DAMAGE1

1997 • 310 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Porcine aortic endothelial cells activate human T cells: Direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28

1994 • 276 citations

Overlapping but Nonidentical Binding Sites on CD2 for CD58 and a Second Ligand CD59

1992 • 165 citations

Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene

1992 • 103 citations

CD59 molecule: A second ligand for CD2 in T cell adhesion

1992 • 98 citations

EXPRESSION OF HUMAN CD59 IN TRANSGENIC PIG ORGANS ENHANCES ORGAN SURVIVAL IN AN EX VIVO XENOGENEIC PERFUSION MODEL1,2

1996 • 93 citations

Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59.

1997 • 92 citations

Complement-inhibiting activities of human CD59 and analogues from rat, sheep, and pig are not homologously restricted.

1994 • 87 citations

Molecular cloning of the rat analogue of human CD59: structural comparison with human CD59 and identification of a putative active site

1994 • 74 citations

Regulatory control of the terminal complement proteins at the surface of human endothelial cells: neutralization of a C5b-9 inhibitor by antibody to CD59

1990 • 72 citations

Molecular cloning and functional characterization of the pig analogue of CD59: relevance to xenotransplantation.

1998 • 62 citations

Mapping the Active Site of CD59

1997 • 58 citations

The CD59 antigen is a structural homologue of murine Ly‐6 antigens but lacks interferon inducibility

1990 • 54 citations

PROTECTION OF PORCINE AORTIC ENDOTHELIAL CELLS FROM COMPLEMENT-MEDIATED CELL LYSIS AND ACTIVATION BY RECOMBINANT HUMAN CD59

1994 • 50 citations

MORPHOLOGY OF hDAF (CD55) TRANSGENIC PIG KIDNEYS FOLLOWING EX-VIVO HEMOPERFUSION WITH HUMAN BLOOD1,2

1997 • 47 citations

Heterodimeric, disulfide‐linked α/β T cell receptors in solution

1991 • 46 citations

Structure-Function Relationships of the Complement Regulatory Protein, CD59

1996 • 44 citations

PROTECTION OF PORCINE AORTIC ENDOTHELIAL CELLS FROM COMPLEMENT-MEDIATED CELL LYSIS AND ACTIVATION BY RECOMBINANT HUMAN CD59

1994 • 41 citations

Identity of the Residues Responsible for the Species-restricted Complement Inhibitory Function of Human CD59

1998 • 39 citations

CD59 costimulation of T cell activation. CD58 dependence and requirement for glycosylation.

1994 • 38 citations

PEC‐A: An immortalized porcine aortic endothelial cell

1995 • 24 citations

Primate terminal complement inhibitor homologues of human CD59

1995 • 21 citations

PCR amplification and physical localization of the genes for pig FSHB and LHB

1995 • 18 citations

Histocompatible Miniature Pig (d/d Haplotype): Generation of Hybridomas Secreting A or M Monoclonal Antibody

1991 • 15 citations

Expression of recombinant CD59 with an N-terminal peptide epitope facilitates analysis of residues contributing to its complement-inhibitory function

1996 • 11 citations