Retinoids and Cancer Prevention

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Prevention of Skin Cancer in Xeroderma Pigmentosum with the Use of Oral Isotretinoin

1988 • 578 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

Experimental cancer of the lung.Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors

1967 • 357 citations

13- cis -Retinoic Acid: Inhibition of Bladder Carcinogenesis in the Rat

1977 • 256 citations

Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.

1977 • 234 citations

An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons.

1965 • 218 citations

In Vitro Binding of Retinol to Rat-Tissue Components

1973 • 217 citations

Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice

1974 • 215 citations

Enhancement of experimental photocarcinogenesis by topical retinoic acid

1979 • 112 citations

DEGREE OF BRONCHIAL METAPLASIA IN HEAVY SMOKERS AND ITS REGRESSION AFTER TREATMENT WITH A RETINOID

1982 • 105 citations

TOPICAL VITAMIN-A-ACID THERAPY FOR CUTANEOUS METASTATIC MELANOMA

1980 • 98 citations

Activity of isotretinoin against squamous cell cancers and preneoplastic lesions.

1982 • 97 citations

Effect of retinoic acid, butylated hydroxytoluene, selenium and sorbic acid on azo-dye hepatocarcinogenesis

1980 • 96 citations

Specificity of cellular retinol-binding protein for compounds with vitamin A activity

1975 • 96 citations

Preventive role of vitamin a in colon carcinogenesis in rats

1977 • 89 citations

Therapy of chemically induced skin tumors of mice with vitamin a palmitate and vitamin a acid

1971 • 83 citations

A retinoic acid-binding protein from chick embryo skin.

1976 • 77 citations

Influence of 15 retinoic acid amides on urinary bladder carcinogenesis in the mouse

1982 • 76 citations

Vitamin A (retinyl acetate) and benzo(alpha)pyrene-induced respiratory tract carcinogenesis in hamsters fed a commercial diet.

1975 • 71 citations

CHEMICALS AND PHOTOCARCINOGENESIS

1977 • 59 citations

The effects of ellagic acid and 13-cis-retinoic acid on N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats

1991 • 57 citations

Inhibition of skin tumor promotion by retinoic acid and its metabolite 5,6-epoxyretinoic acid.

1980 • 53 citations

A phase I trial of topically applied trans-retinoic acid in cervical dysplasia-clinical efficacy

1986 • 48 citations

Effect of Retinyl Acetate on the Incidence of Mammary Carcinomas and Hepatomas in Mice<xref ref-type="fn" rid="FN2">2</xref>

1980 • 46 citations

Retinoic acid promotion of papilloma formation in mouse skin

1982 • 42 citations

Modifying effect of dietary fat on benzo[a]pyrene-induced respiratory tract tumours in hamsters

1984 • 38 citations

Enhancement by Retinyl Acetate of Hormone-Induced Mammary Tumorigenesis in Female GR/A Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 36 citations

Inhibition of Pancreatic and Liver Carcinogenesis in Rats by Retinoid- and Selenium-Supplemented Diets

1988 • 33 citations

Fluorinated retinoic acids and their analogs. 3. Synthesis and biological activity of aromatic 6-fluoro analogs

1982 • 33 citations

Comparative activity of dietary or topical exposure to three retinoids in the promotion of skin tumor induction in mice.

1987 • 32 citations

Inhibitory effect of an aromatic retinoic acid analog on urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

1980 • 25 citations

Effect of retinyl acetate and 4-hydroxyphenylretinamide on initiation of chemically-induced mammary tumors.

1990 • 24 citations

Effects of dietary retinyl palmitate or 13-cis-retinoic acid on the promotion of tumors in mouse skin.

1987 • 24 citations

Lack of inhibition by retinoids of bis(2-oxopropyl)nitrosamine- induced carcinogenesis in Syrian hamsters

1983 • 21 citations

Effects of excess vitamin A and canthaxanthin on salivary gland tumors

1988 • 21 citations

Chemopreventive and antineoplastic activity of N-homocysteine thiolactonyl retinamide

1987 • 19 citations

Inhibition of rat mammary carcinogenesis by an arotinoid without a polar end group (Ro 15-0778)

1987 • 18 citations

Sex differences in the effects of retinoids on carcinogenesis by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters

1981 • 18 citations

Inhibition by Retinoids of the Growth of Azaserine-Induced Foci in the Rat Pancreas<xref ref-type="fn" rid="FN2">2</xref>

1984 • 18 citations

Cumulative reduction of primary skin tumor growth in UV-irradiated mice by the combination of retinyl palmitate and canthaxanthin

1990 • 16 citations

The effects of arotinoids on rat mammary carcinogenesis

1985 • 16 citations

Synergistic interaction between 13-cis-retinoic acid and glucarate: Activity against rat mammary tumor induction and MCF-7 cells

1989 • 13 citations

Synthetic retinamides: effect on urinary bladder carcinogenesis by FANFT in Fischer rats

1981 • 12 citations

Therapeutic effect of the arotinoid Ro 15-0778 on chemically induced rat mammary carcinoma

1988 • 12 citations

Phase II Study of 13-cis-Retinoic Acid in Pediatric Patients with Acute Nonlymphocytic Leukemia—A Pediatric Oncology Group Study

1991 • 10 citations

Effects of four retinoids in N-nitrosobis(2-oxopropyl)amine-treated hamsters.

1983 • 9 citations

Influence of 13-cis-retinoic acid on mouse skin tumor initiation and promotion

1984 • 9 citations

Antineoplastic Activity of N-maleamide Homocysteine Thiolactone Amide Encapsulated within Liposomes

1985 • 7 citations

Retinyl acetate inhibition of 3'-methyl-4-dimethyl-aminoazobenzene induced hepatic neoplasia

1990 • 6 citations

Effect of all‐trans retinoic acid on induction, lethality and immunogenicity of murine methylcholanthrene‐induced fibrosarcomas

1982 • 6 citations

Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-promoted tumor formation in CD-1 and Sencar mice

1988 • 5 citations

Influence of excess of retinoid on DMBA carcinogenesis.

1983 • 5 citations

Null effects of vitamin A analogs on the dimethylnitrosamine kidney tumor model

1984 • 5 citations

Effect of long-term administration of retinoids on rats exposed transplacentally to ethylnitrosourea.

1985 • 5 citations

Influence of vitamin A on the formation of ethylnitrosourea (ENU)-induced leukemias.

1983 • 3 citations

A protective role of 13-cis retinoic acid in thymic lymphoma induction.

1985 • 1 citations