A phase II study of irinotecan (CPT‐11) in patients with advanced squamous cell carcinoma of the cervix

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

Cancer statistics, 1996

1996 • 1,807 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

1989 • 645 citations

CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer.

1992 • 443 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

Randomized trial of three cisplatin dose schedules in squamous-cell carcinoma of the cervix: a Gynecologic Oncology Group study.

1985 • 399 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Phase I and pharmacokinetic trial of weekly CPT-11.

1993 • 300 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

DNA Topoisomerases as Anticancer Drug Targets

1990 • 195 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix.

1997 • 135 citations

Inhibition of spontaneous and experimental metastasis by a new derivative of camptothecin, CPT-11, in mice

1988 • 87 citations

Topoisomerases: Novel therapeutic targets in cancer chemotherapy

1988 • 40 citations

Interleukin-1 alpha-induced modulation of topoisomerase I activity and DNA damage: implications in the mechanisms of synergy with camptothecins in vitro and in vivo.

1996 • 7 citations

Interferon-alpha potentiates the antiproliferative activity of CPT-11 against human colon cancer xenografts in nude mice.

1996 • 3 citations

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